Dr David William Cleary
Research Interests
Dr Cleary’s research interests fall into four broad areas:
Genomic Epidemiology of Streptococcus pneumoniae: This involves collaboration with the group of Prof. Stuart Clarke (University of Southampton) and his ongoing paediatric pneumococcal carriage study as well as international partners in South-east Asia, particularly Malaysia.
Non-typeable Haemophilus influenzae (NTHi): Specifically, epidemiology in paediatric carriage, as the cause of non-invasive infections and in those with chronic respiratory disease such as COPD. This includes collaboration with Prof. Margaret Ip (Chinese University of Hong Kong).
Upper Respiratory Tract Microbiomes: Research focussing on ecological shifts that enable outgrowth of a particular pathogen(s) or alteration in host responses to microbial encounters. Also includes an exploration of interactions between opportunistic pathogens and commensals such as Dolosigranulum and Corynebacterium sp.
Controlled Human Infection Models (CHIM): Dr Cleary remains involved with Controlled Human Infection Model (CHIM) research with the University of Southampton. Here he studies genomic stability of bacterial inocula during challenge as well as the impact on resident microflora.