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Social brain fingerprints of social behaviour: using network science to extract neural correlates of interpersonal (dys)function
Secondary Supervisor(s): Dr Charlotte Pennington, Dr Enrico Amico
University of Registration: Aston University
BBSRC Research Themes: Understanding the Rules of Life (Neuroscience and Behaviour)
Project Outline
Research by one of the co-supervisors of this studentship has shown that patterns of functional brain connectivity estimated from functional resonance magnetic imaging (fMRI) data can be used to identify a given individual in a set of functional connectivity profiles from a population (Van De Ville et al., 2021). This technique - “brain fingerprinting” - can provide useful insights into the individual features that distinguish our brains from one another, and how those features might drive inter-individual variability in cognition and behaviour. Individual differences in cognition and behaviour are evident particularly in social contexts, wherein our unique inter-personal competencies and dispositions determine the ways in which we interact with others. By acquiring fMRI data from individuals engaged in real social interactions - “second-person neuroscience” – the Primary Supervisor of this studentship has revealed systematic patterns of functional brain connectivity that appear to coordinate interpersonal behaviour (Shaw et al., 2023).
This project will by combine brain fingerprinting and second-person neuroscience techniques to identify “social brain fingerprints” that underpin individual differences in interactive behaviour, and disruptions to which might underpin the dysfunctional interpersonal behaviour recognised as a transdiagnostic criterion of many disorders. This will establish a novel line of research. To ensure methodological robustness throughout this process, the student will also be co-supervised and trained in open research practices by a local lead of the Reproducibility Network (Pennington, 2023).
Objective 1: Identify brain fingerprints that predict individual expressions of reciprocity during social interaction.
Brain fingerprinting will be applied to fMRI data acquired from healthy individuals using a second-person paradigm - the iterated Ultimatum Game (iUG). On this task, pairs of individuals will undergo fMRI while they interact with one another over multiple monetary exchanges with the goal of maximising their own eventual payout. To maximise their payout, both players must adapt to and reciprocate the behaviour of their opponent. Brain fingerprinting applied to these fMRI data will therefore identify features of “social brain fingerprints” that explain inter-individual variability in expressions of reciprocity. This will achieve unprecedented insights into the different brain networks and subsystems recruited during expressions of reciprocity during social interactions.
Objective 2: Define features of brain fingerprints associated with maladaptive expressions of reciprocity in autism.
Autism is characterised by difficulties in social interaction and communication, manifesting as atypical social-emotional reciprocity. To determine the social brain fingerprints of such behaviour, brain fingerprinting will be applied to fMRI data acquired from pairs of autistic and non-autistic individuals while they interact with one another on the iUG. Pilot data acquired by the supervisory team indicate that autistic individuals show altered expressions of reciprocity compared to their healthy co-players, and this is associated with the severity of the autistic phenotype. In this project, the successful candidate will identify social brain fingerprints in the autistic sample that differ from the “healthy” social brain fingerprint(s) identified in Objective 1, and then define features of these fingerprints associated with these altered expressions.
References
Pennington, C. R. (2023). A student’s guide to open science: Using the replication crisis to reform psychology. Open University Press.
Shaw, D. J. et al. (2023). The interacting brain: dynamic functional connectivity among canonical brain networks dissociates cooperative from competitive social interactions. NeuroImage, 269, 119933.
Van De Ville, D. et al. (2021). When makes you unique: Temporality of the human brain fingerprint. Science advances, 7(42), eabj0751.