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Prof Daniel Panne

D Panne

Contact Details

Professor Daniel Panne

 

Department of Molecular and Cell Biology, University of Leicester


Research Interests

Our research has focused on understanding how signalling pathways control gene expression by epigenetic modulation of chromatin structure. One of the best-understood model systems for metazoan gene regulation is found in the innate immune system, which is crucial to limit pathogen infections: Several groups of pattern recognition receptors induce different signalling pathways leading to production of a variety of antiviral molecules including type I interferons and proinflammatory cytokines. Previous work from the laboratory has revealed mechanistic and structural insights into how the interplay between cellular signalling, TF activation and coassembly on transcriptional enhancers controls gene expression (Fig. 1). Higher-order transcription factor complexes such as the enhanceosome frequently recruit the co-activators CBP/p300. CBP/p300 are important to integrate the cellular signals by providing a scaffold function. CBP/p300 also acetylate chromatin and ultimately, in conjunction with remodellers and histone chaperones, makes chromatin permissive for gene transcription.

Scientific Inspiration

JD Bernal! He was maybe one of the most influential scientists of the past century. He realised that analysis of the structure of proteins could be applied to study of life at a fundamental level. His pioneering work at Cambridge in the 1930s laid the foundation of molecular biology.


Supervision Style

We strive to provide a collaborative and inclusive supervision style.

Provision of Training

At first you will receive technical training to ensure that the different workflows will be mastered. For this you will receive supervision by experienced lab members including PI, post docs /PhD students leading to more independence later.

Progression Monitoring and Management

We will discuss progress and results obtained in a weekly laboratory meeting. We will provide a supportive environment with the aim that you reach the goals you set for yourself.

Communication

We regularly talk to each other during the week and discuss the latest progress/results if necessary.

PhD Students can expect scheduled meetings with me:

In a group meeting

At least once per week

In year 1 of PhD Study

At least once per week

In year 2 of PhD Study

At least once per week

In year 3 of PhD Study

At least once per week

These one on one meetings will be mainly face to face, and I am usually contactable for an instant response on every working day.

Working Pattern

The timing of work in my lab is completely flexible, and (other than attending pre-arranged meetings), I expect students to manage their own time.

Notice Period for Feedback

I need at least 1 week’s notice to provide feedback on written work of up to 5000 words.