Dr Jon Hazeldine is a trained immunologist with a long-standing interest in how major trauma and thermal injury modulates the innate immune system.

His research is focussed primarily around understanding the mechanisms that underlie the immediate (<1 hour), acute (4-72 hours) and persistent (up to 1-year) state of systemic immuneparesis that develops in severely injured patients and its relationship with such clinical outcomes as sepsis and multiple organ dysfunction.

Research Themes

• The effect of major trauma on innate immunity.
• Mechanisms underlying trauma-induced immune suppression.
• The immune and inflammatory response to thermal injury.
• How the immune and inflammatory response to severe injury influences patient outcomes (e.g. development of sepsis).