Dr Jill Johnson
Supervisor Details
Research Interests
Dr Johnson’s research focuses on the role of vascular pericytes in allergic asthma, specifically the progenitor cell capacity of these cells and their contribution to asthma pathogenesis.
In the Johnson lab, an established mouse model of asthma driven by chronic respiratory exposure to house dust mite (HDM) is used to induce chronic allergic asthma in a way that closely mimics human asthma. We have demonstrated that, following chronic HDM exposure, pericytes detach from the microvasculature and accumulate within the smooth muscle bundles of the airways, thus contributing to airway remodelling and lung dysfunction (Johnson et al., AJP Lung 2015). Pericytes in the respiratory microvasculature are evaluated in control mice as well as in HDM-exposed mice using immunofluorescent confocal microscopy, FACS analysis and cell culture. Other projects in the Johnson lab are investigating the molecular mechanisms by which chronic inflammation affects mesenchymal progenitor cell differentiation and migration and assessing the impact of smoke exposure and oxidative stress on pericyte function in COPD.
Scientific Inspiration
I am inspired by scientists who have persevered in their research despite opposition from the establishment – Robert Hooke, Charles Darwin, Rosalind Franklin, Cecilia Payne-Gaposchkin.
Research Groups
Project Details
Dr Jill Johnson is supervising no projects this year.