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Dr Jose Romero

Supervisor Details

Contact Details

Dr Jose Romero Hombrebueno

Department of Inflammation and Ageing, University of Birmingham

Research Interests

Jose's research focus is on understanding how mitochondrial dysfunction impacts on eye disease and whether it can be targeted for therapy. Irreversible mitochondrial dysfunction involves a major event in many ocular disorders, including diabetic retinopathy, optic neuropathies, inflammatory and aging-related disorders. The accumulation of broken mitochondria may pose a severe risk for vision, since 1) damaged mitochondria do not produce energy efficiently and disrupts the power system of the retina and 2) they are a source of toxic waste, which may origin retinal disease. In the healthy retina, this problem is prevented by tight Mitochondrial Quality Control (MQC), where faulty mitochondria are simply removed and replaced by newly-synthetized functional units. Using appropriate disease models, Jose pursues to determine how MQC becomes dysregulated in ocular disease and its contribution to neurovascular degeneration. His main goal focuses in applying this knowledge to develop novel interventional strategies for eye therapy.


MIBTP Project Details

Current Projects (2025-26)

Co-supervisor on a project with Dr Rahul Mahida.