Dr Manish S Kushwah

Supervisor Details

Contact Details

Scientific Background

Research Interests

I have a long-standing interest in studying mechanisms of protein-catalyzed membrane-remodelling by membrane remodelling proteins (MRPs) in vesicular transport. Cryo-EM studies of different MRPs show that they display vary different organisation on membranes. Moreover, they also show preferential lipid affinity which determines their localisation to intracellular compartments. I am interested in understanding how lipid affinity, in combination with MRPs ability to polymerise on membranes determines their preferential localisation in cells. To understand the underlying mechanisms for preferential MRP localisation and assembly, we are developing in-vitro approaches to study quantify lipid-protein affinity, MRP polymerisation and polymerisation induced change in membrane dynamics. For this purpose, we are combining dynamic mass photometry (DMP), fluorescence microscopy and functional reconstitution of MRP polymerisation on variety of membrane templates.

Research Groups

Aston Institute for Membrane Excellence (AIME)

Supervision Style

In three words or phrases: Supportive, detail-oriented and collaborative.

Provision of Training

I believe in continuous improvement of the student as they go through their PhD. Initially, I will take responsibility of the training of the student and with time, I expect student to become self-sufficient to lead the project. However, I will always be around to help out or find right people to ensure the academic development of the student.

Progression Monitoring and Management

I prefer to work together, which means there is a constant dialogue with the student. This does not mean student does not have independence, but I want to ensure we can student has sufficient support through the PhD.

Communication

I am known to email my team/PhD students at all hours of the day and night, however I will not expect you to do the same. I am happy to discuss any issues that are impacting your ability to fulfil your potential or my/our expectations.

PhD Students can expect scheduled meetings with me at least once per week. These meetings will be a mixture of face to face and via video chat or telephone, and I am usually contactable for an instant response on every working day.

Working Pattern

Certain tasks in my lab need to occur at set times, and students need to be able to commit to a rota/timetable shared with other members of the team.

Notice Period for Feedback

I need at least 1 week’s notice to provide feedback on written work of up to 5000 words.

MIBTP Project Details

Primary supervisor for:

Project details will appear here when confirmed.

See the PhD Opportunities section to see if this project is currently open for applications via MIBTP.

Please Note: The main page lists projects via BBSRC Research Theme(s) quoted and then relevant Topic(s).

Project Title

Secondary Supervisor(s):

University of Registration:

BBSRC Research Themes:

Sustainable Agriculture and Food (Animal Health and Welfare,Microbial Food Safety,Plant and Crop Science)
Renewable Resources and Clean Growth (Bio-energy,Industrial Biotechnology)
Understanding the Rules of Life (Immunology,Microbiology,Neuroscience and Behaviour,Plant Science,Soil Science,Stem Cells,Structural Biology,Systems Biology)
Integrated Understanding of Health (Ageing,Diet and Health,Pharmaceuticals,Regenerative Biology)

Project Outline

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