Dr Marco Saponaro
Supervisor Details
Research Interests
Dr Saponaro is interested in characterising mechanisms of genome stability maintenance. In particular he is interested in understanding how RNA Pol II transcription, especially when in mutant contexts that affect transcription progression, can induce genome instability. He develops his research combining whole genome analyses with functional studies. He characterises RNA Pol II progression identifying how it is affected in mutant contexts, correlating transcription problems with the sites of genome instability. All these allow identifying the mechanisms of transcription-induced genome instability.
He is also interested in the relevance for human health of transcription-associated genome instability, identifying instances where these problems arise and approaches to exploit therapeutically these situations.
Scientific Inspiration
He is called Piero Angela, the equivalent of David Attenborough for generations of Italians.
Research Groups
MIBTP Project Details
Previous Projects (2024-25)
Co-supervisor on a project with Dr Aga Gambus.