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Understanding upper-limb function with transcutaneous spinal cord stimulation
Secondary Supervisor(s): Dr Tom Nightingale
University of Registration: University of Birmingham
BBSRC Research Themes:
Project Outline
Understanding upper-limb function with transcutaneous spinal cord stimulation
Background — Transcutaneous spinal cord stimulation (TSCS) is a technique where electrodes are placed on the skin over specific vertebral levels targeting the posterior spinal roots. Stimulation is thought to increase the excitability of spinal interneurons and motor-neurons, though the exact mechanisms are not clearly understood. While TSCS is a promising tool to investigate the human motor system, much of the research is still in the early stages. This fact is especially true in healthy populations, as most research has focused on patient populations, such as people with spinal-cord injury.
Project Outline — This project will test different forms of TSCS e.g. direct current, or carrier-wave driven, different stimulation parameters and different electrode configurations to:
i) understand the neural mechanisms of TSCS
ii) investigate how TSCS influences the control of the upper limbs
iii) investigate the differences in response between young and older adults
We will use the following techniques:
• Transcutaneous spinal cord stimulation
• Electromyography (EMG) and High-density EMG
• Transcranial magnetic stimulation
• Transcranial direct-current stimulation
• Behavioural motor testing
• Physiological testing— i.e. motor reflexes
To investigate how TCSCS influences:
• Cortico-spinal-motor excitability
• Non-voluntary control of the upper limbs, e.g. the H-reflex
• Motor thresholds and excitability
• Voluntary motor control of the upper limbs