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Professor Peter B O'Connor

Supervisor Details

Peter O'Connor

Contact Details

Professor Peter B O'Connor

Department of Chemistry, University of Warwick

 

Research Interests

I am currently interested in improving the performance and applications of Fourier Transform Ion Cyclotron Resonance (FTICR) mass spectrometers; fundamental studies of the mechanism of electron capture dissociation; FTICR instrument design; post-translational modification analysis of proteins and peptides; and deamidation and isomerization of aspartic acid residues in peptides and proteins.

Scientific Inspiration

A fascinating question! But not a short one to answer. I’ll try to be brief.

A. Professor Fred W. Mclafferty, Cornell University. Fred was my PhD supervisor and became my mentor and essentially my academic father. He was an impressively intelligent and charming man, but he relished the academic argument process whereby science reveals truth. Sceptical (scientifically) to a fault, but perpetually human, approachable, and helpful. We lost him recently, and I miss him. He was the consummate mass spectrometrist, with an organic chemistry synthesis background (he has a very famous organic rearrangement named after him) and the undisputed master of fragmentation mechanisms. His contributions to the field include GC/MS, high resolution MS, protein MS, top-down protein sequencing, and several of the key fragmentation methods.

B. Professor Catherine Costello. Boston University School of Medicine. Cathy was my mentor in the Assistant/Associate professor phases of my career, and I still have complete trust in her and in her keen perception of people. She is always helpful and supportive, and just a wonderful person. She is most known for her understanding and advocacy of mass spectrometry of glycans, oligosaccharides, and lipids, and she taught me how to collaborate with biochemists, molecular biologists, medical and clinical scientists, and every other colleague at a medical school who needed good analytical research.

C. Professor Alan Marshall. Florida State University. I never worked with Alan, but I’ve known him all my career as his development of FTICR mass spectrometry was the key underlying development that I had to master in my PhD studies with Fred. His work was revolutionary and keenly insightful, and I’ve always read his papers with great interest.

D. A few other key people who have impressed me over the years are Professor Franz Hillenkamp, Muenster (who should have won the Nobel prize for MALDI instead of Tanaka – happy to show you the papers) and Professor Ron Heeren, Maastricht University, a long-time friend and co-worker from when I was a postdoc in Amsterdam. Ron now runs the EU’s biggest and best imaging mass spectrometry laboratory.

Research Groups

Peter O'Connor Group


MIBTP Project Details

Previous Projects (2024-25)

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