Dr Richard Hopkinson

Supervisor Details

Contact Details

Dr Richard Hopkinson

School of Chemistry, University of Leicester

Scientific Background

Research Interests

Research group activity

Understanding the functional role of formaldehyde in health and disease.

My research is focused on understanding how reactions between biomolecules and reactive small molecules, most notably formaldehyde, affect biological systems in health and disease. Formaldehyde, the simplest aldehyde, is a highly-reactive and often toxic electrophile that is a by-product of enzymatic demethylation reactions in human cells. The mechanisms underpinning formaldehyde toxicity are poorly understood, which is likely a consequence of its complex and uncharacterised reactivity with biomolecules, often involving unstable intermediates. My research uses chemical/synthetic, biochemical and cellular methods to identify and characterise the complex biologically relevant chemistry of formaldehyde with biomolecules. Ultimately, we hope to define the mechanisms underpinning formaldehyde homeostasis and biology in health and disease.

Research Groups

The Hopkinson Group

Supervision Style

In three words or phrases: Laid-back, spontaneous, inclusive.

Provision of Training

Your training will be supervised partly by myself but also by my experienced post docs and PhD students. I will take overall responsibility for your technical training at first, leading to more independence later.

Progression Monitoring and Management

I like to be kept up to date, and would like to be informed when new method development/data generation results emerge, preferably on a weekly basis. I am here for advice and guidance to help you reach the goals you set for yourself.

Communication

I have an informal and laid back communication style. I am known to email my team outside of regular hours, however I do not expect anyone to read or reply to them. I am happy to discuss any issues that are impacting your ability to fulfil your potential.

PhD Students can expect scheduled meetings with me:

In a group meeting

At least once per week

In year 1 of PhD study

At least once per week

In year 2 of PhD study

At least once per week

In year 3 of PhD study

At least once per week

The meetings will be face to face and I am usually contactable for an instant response (if required) on every working day.

Working Pattern

The timing of work in my lab is completely flexible, and (other than attending pre-arranged meetings), I expect students to manage their own time.

Notice Period for Feedback

I need at least 1 week’s notice to provide feedback on written work of up to 5000 words.

MIBTP Project Details

Previous Projects (2024-25)

Primary supervisor for:

Evaluating the impact of genotoxic aldehyde stress in premature ageing

Previous Projects (2023-24)

Primary supervisor for:

Treating bacterial infections using aldehydes