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Dr Stephane De Brito

Supervisor Details

Dr Stephane De Brito

Contact Details

Dr Stephane De Brito

School of Psychology, University of Birmingham

Dr De Brito is a psychologist and director of the Social, Cognitive, Affective, and Neuroscience (SCAN) lab. Research in the SCAN lab focuses on understanding the mechanistic interplay between the social, cognitive, affective, and neurocognitive factors implicated in the development and persistence of antisocial and aggressive behaviour. A second strand of research examines those aspects among youths who have experienced early adversity.

Scientific Inspiration

Jean-Piaget for its systematic approach to research.


Project Details

Dr De Brito is the supervisor on the below project:

Enhancing Neuroimaging Genetics through Meta-analysis (ENIGMA): Antisocial Behaviour working group

Secondary Supervisor(s):Professor Georgios Gkoutos, Centre for Health Data Science; Professor Peter Tino, Computer Science, University of Birmingham

University of Registration:University of Birmingham

BBSRC Research Themes:Understanding the Rules of Life (Neuroscience and Behaviour)

Apply here!

Deadline: 4 January, 2024


Project Outline

ENIGMA is an international collaborative effort that brings together over 1400 researchers across 43 countries to better understand brain structure, function, health and disease, based on meta-/mega-analyses of brain imaging and genetic data (http://enigma.ini.usc.edu). There are currently over 50 active ENIGMA working groups covering various fields within psychiatry and neuroscience (see our recent review here). We have recently set-up the ENIGMA Antisocial Behaviour working group on which the student will work. Despite notable advances in recent years, the overall impact and replicability of work in this field has been limited by small sample sizes and heterogeneous participant characteristics, imaging acquisition methods, and data analysis techniques. The harmonized meta-analytical approach of ENIGMA allows one to address these challenges more adequately, gain deeper insights into underlying pathophysiology, and generate more reproducible and generalizable findings.

The ENIGMA Antisocial Behavior initiative will focus on data covering the entire lifespan; this includes structural and functional MRI data on Conduct Problems/Disorder in youths, as well as Antisocial Personality Disorder/Psychopathy in adults. Analyses will not only be focused on disorders and categorical approaches, but also dimensional approaches where neuroimaging/genetics data that can be linked to dimensional measures indexing externalizing behaviors and environmental risk factors (e.g., early childhood adversity) in both clinical/forensic and community samples. The student working on this project will have the opportunity to liaise and network with researchers across the globe. There will be opportunities for training at the ENIGMA headquarter at the University of Southern California as well as with our ENIGMA collaborators in the Netherlands. The project will combine and train the student in methods from psychology, neuroimaging, and computer/data science, which together will put this project at the forefront of research on antisocial behaviour.

References

Staginus, M., […], De Brito, S.A., & Fairchild, G.F. (2023). Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 8:6, 609-619.

De Brito, S. A. et al. (2021). Nature Reviews Disease Primers. 7:49.

Thompson, P. M., […] De Brito, S.A., […] ENIGMA Consortium (2020). Translational Psychiatry. 10:100.

Techniques

  • Advanced multivariate analyses (e.g., machine learning)
  • Structural and functional MRI
  • Meta-analysis and mega-analysis of MRI data
  • Programming

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