Professor Salvador Macip

Supervisor Details

Contact Details

Department of Molecular Cell Biology, University of Leicester

Scientific Background

Research Interests

My research interest is to understand the mechanisms involved in cancer and ageing in order to design better targeted and personalized therapies for cancer and other age-related diseases.

Research group activity

Project 1. Precision medicines for B-cell leukaemias. In collaboration with Prof Martin Dyer's lab we are defining novel personalized therapeutic strategies against B-cell malignancies that can be immediately applied in the clinic. For instance we studied the response of a patient with Hairy Cell Leukaemia to BRAF inhibitor vemurafenib both from the clinical perspective and at a cellular and molecular level.
Project 2. Understanding the molecular mechanisms of ageing. Our experiments on senescence (cellular ageing) will allow us to better understand why we age and also will provide the basis for new treatments that could be applied to slow down and improve ageing. We have already identified novel markers of senescence that could be used to detect senescent cells in vivo and in vitro.

Research Groups

Mocca Lab - The Mechanisms of Cancer and Ageing

Supervision Style

In three words or phrases: Supportive, collaborative, nurturing.

Provision of Training

The goal is to work together towards technical and intellectual independence. You will be trained, guided and helped by me and other members of the lab.

Progression Monitoring and Management

I will expect you to take ownership of your progression but come to me when you need help troubleshooting. Also, I like to be kept up to date, and will expect to see data and discuss results and the experimental plan regularly. I am here for advice and guidance to help you reach the goals you set for yourself.

Communication

My door is always open and I am happy to discuss any issues anytime. The team has a WhatsApp group chat with which we regularly communicate. I am always reachable by phone, email or in person. I am approachable and available for scientific and persona support.

PhD Students can expect scheduled meetings with me:

In a group meeting

At least once per week

In year 1 of PhD study

Our meetings are not scheduled, but we see each other very often, sometimes briefly, sometimes longer meetings.

In year 2 of PhD study

Our meetings are not scheduled, but we see each other very often, sometimes briefly, sometimes longer meetings.

In year 3 of PhD study

Our meetings are not scheduled, but we see each other very often, sometimes briefly, sometimes longer meetings.

The meetings will usually be face to face, otherwise via video chat or telephone and I am usually contactable for an instant response (if required) on every working day.

Working Pattern

The timing of work in my lab is completely flexible, and (other than attending pre-arranged meetings), I expect students to manage their own time.

Notice Period for Feedback

I need at least 1 week’s notice to provide feedback on written work of up to 5000 words.

MIBTP Project Details

Current Projects (2025-26)

Ameliorating ageing, age-related diseases and cancer by targeting senescence and the p53 pathway

See the PhD Opportunities section to see if this project is currently open for applications via MIBTP.

Please Note: The main page lists projects via BBSRC Research Theme(s) quoted and then relevant Topic(s).

Ameliorating ageing, age-related diseases and cancer by targeting senescence and the p53 pathway

Secondary Supervisor(s): Professor Shaun Cowley

University of Registration: University of Leicester

BBSRC Research Themes: Integrated Understanding of Health (Ageing)

Project Outline

Ageing is a process defined by the accumulation of old (senescent) cells in tissues. It has been shown that senescent cells interfere with the normal functions of most organs and thus lead to the phenotypic changes associated with ageing, as well as the establishment of age-related diseases. Together, these are responsible for loss in quality of life and the eventual reduction of lifespan of an organism. The genetic factors involved in triggering and maintaining senescence have not been fully characterized. Our main goal is to take advantage of novel markers and effectors of senescence, particularly those related to the p53 pathway, in order to:

i) better understand the molecular processes involved in human ageing.

ii) define new therapies that target senescence, which should:

- ameliorate age-related diseases, such as cancer, fibrosis and neurodegenerative diseases (Alzheimer’s, Parkinson’s, etc.).

- delay and/or ameliorate the symptoms of ageing, with the final goal of slowing/reverting the process in humans and thus increase lifespan and healthspan.

Through an initial proteomics screening, we identified several novel potential components of the senescent pathway¹, and we showed that inhibition of one of them delays ageing in a mouse model² due to its control of p53³. Recent screens are in process to obtain a panel of tissue-specific markers of ageing.

We propose to study the role of these proteins in senescence and ageing. Our research plan will include:

a) Assessing the effects of potential effectors of senescence by inhibiting/overexpressing them in different cellular models (such as fibroblasts aged in culture or derived from premature ageing syndromes, or stress-induced senescent normal and cancer cells). By doing this, we will also study the changes in gene expression that define the senescent phenotype. Preliminary data suggests that certain chemical inhibitors of these proteins can block senescence (and may, therefore, have potential effects in ageing). We will test their effect on cell and organismal ageing.

b) Defining novel markers of senescence. The methods currently available to detect senescent cells need to be improved. We plan to characterize several novel proteins upregulated in senescence to be used as new and more efficient/specific markers. We have recently shown that such markers could have prognostic potential in diseases such as cancer. With the help of our collaborators, we will develop systems to detect senescent cells in tissues and in culture. This has therapeutic potential (see below) but could also be useful to determine the percentage of senescent cells in tissues and thus its biological ageing. Comparisons to chronological ageing could have diagnostic and prognostic value.

c) Establishing new protocols for clearing senescence cells. It has been shown in mouse models that eliminating senescent cells from tissues suppresses the symptoms of ageing and prolongs lifespan⁴. We will use our newly identified markers to selectively target senescent cells using tools such as peptides, nanoparticles, monoclonal antibodies, etc. This aim will also be performed with our collaborators at the Department of Chemistry and commercial partners, which will provide targeted compounds that could selectively detect and kill senescent cells. We will also test them in in vivo models if possible.

We expect our experiments to clarify the mechanisms involved in the senescence pathway, which are still poorly defined, as well as to provide new tools for the study of senescent cells and possible diagnostic/therapeutic interventions that could increase health and quality of life in older populations in the future.

Techniques

Techniques that will be undertaken during the project:

The student will use techniques such as protein/DNA/RNA extraction, microscopy, immunofluorescence, immunohistochemistry, subcellular fractionation, gradient separation, cloning, transfection, RNA interference, flow cytometry, Western blots, luciferase assays, quantitative Real Time PCR, microarrays and mass spectrometry. The student will also be taught to process data, including image editing with Photoshop and advanced statistical analysis of data with R, using quantitative tools such as Excel, GrahPad’s Prism and Image J, among other specific software regularly used in the lab.

Co-supervisor on a project with Dr Richard Doveston.

Previous Projects (2024-25)

Primary supervisor for:

Ameliorating ageing, age-related diseases and cancer by targeting senescence and the p53 pathway

Co-supervisor on a project with Dr Richard Doveston.

Previous Projects (2023-24)

Primary supervisor for:

Ameliorating ageing, age-related diseases and cancer by targeting senescence and the p53 pathway