Human Infections

Infectious diseases pose a major threat to human health worldwide. Research in WIDER is at the cutting edge of addressing problems of national or global importance, providing a range of predictions and statistical analyse that have direct policy implications.

Current active research includes:

Previous research includes:

Recent Selected Publications

2015

Rock, K.S., le Rutte, E.A., de Vlas, S.J., Adams, E.R., Medley, G.F., Hollingsworth, T.D. (2015) Uniting mathematics and biology for control of visceral leishmaniasis. Trends in Parasitology 31 251 - 259

Truscott, J., Hollingsworth, T.D., Anderson, R. (2015) Modeling the Interruption of the Transmission of Soil-Transmitted Helminths by Repeated Mass Chemotherapy of School-Age Children. PLoS Neglected Tropical Diseases 8 e33239

Rock, K.S., Wood, D.A., Keeling, M.J. (2015) Age- and bite-structured models for vector-borne diseases. Epidemics (in press).

Baggaley, R.F., Hollingsworth, T.D. (2015) Brief report: HIV-1 transmissions during asymptomatic infection: Exploring the impact of changes in HIV-1 viral load due to coinfections. Journal of Acquired Immune Deficiency Syndromes 68 594 - 598

Hollingsworth, T.D., Pulliam, J.R.C., Funk, S., Truscott, J.E., Isham, V., Lloyd, A.L. (2015) Seven challenges for modelling indirect transmission: Vector-borne diseases, macroparasites and neglected tropical diseases. Epidemics (in press)

Metcalf, C.J.E., Andreasen, V., Bjørnstad, O.N., Eames, K., Edmunds, W.J., Funk, S., Hollingsworth, T.D., Lessler, J., Viboud, C., Grenfell, B.T. (2015) Seven challenges in modeling vaccine preventable diseases. Epidemics (in press)

Ball, F., Britton, T., House, T., Isham, V., Mollison, D., Pellis, L., Scalia Tomba, G. (2015) Seven challenges for metapopulation models of epidemics, including households models. Epidemics (in press)

Heesterbeek, H., Anderson, R.M., Andreasen, V., Bansal, S., de Angellis, D., Dye, C., Eames, K.T.D., Edmunds, W.J., Frost, S.D.W., Funk, S., Hollingsworth, T.D., House, T., Isham, V., Klepac, P., Lessler, J., Lloyd-Smith, J.O., Metcalf, C.J.E., Mollison, D., Pellis, L., Pulliam, J.R.C., Roberts, M.G., Viboud, C., Isaac Newton Institute IDD Collaboration (2015) Modeling infectious disease dynamics in the complex landscape of global health. Science 347 6227

Rock, K.S., Stone, C.M., Hastings, I.M., Keeling, M.J., Torr, S.J., Chitnis, N (2015) Mathematical Models of Human African Trypanosomiasis Epidemiology. Advances in Parasitology 87 53-133

Griffin, J.T., Déirdre Hollingsworth, T., Reyburn, H., Drakeley, C.J., Riley, E.M., Ghani, A.C. (2015) Gradual acquisition of immunity to severe malaria with increasing exposure. Proceedings of the Royal Society B: Biological Sciences 282 8

Baggaley, R.F., Hollingsworth, T.D. (2015) HIV-1 transmissions during asymptomatic infection: exploring the impact of changes in HIV-1 viral load due to coinfections. Journal of Acquired Immune Deficiency Syndromes. (in press)

2014

Klepac, P., Funk, S., Hollingsworth, T.D., Metcalf, C.J.E., Hampson, K. (2014) Six challenges in the eradication of infectious diseases. Epidemics (in press)

Hancock, P.A., Rehman, Y., Hall, I.M., Edeghere, O., Danon, L., House, T.A., Keeling, M.J. (2014) Strategies for controlling non-transmissible infection outbreaks using a large human movement data set. PLoS Comp. Biol. 10 e1003809.

Matlashewski, G., Arana, B., Kroeger, A., Be-Nazir, A., Mondal, D., Nabi, S.G., Banjara, M.R., Das, M.L., Marasini, B., Das, P., Medley, G., Satoskar, A., Nakhasi, H., Argaw, D., Reeder, J., Olliaro, P. (2014) Research priorities for elimination of visceral leishmaniasis. The Lancet Global Health 2 e683 - e684

Pinsent, A., Read, J.M., Griffin, J.T., Smith, V., Gething, P.W., Ghani, A.C., Pasvol, G., Hollingsworth, T.D. (2014) Risk factors for UK Plasmodium falciparum cases. Malaria Journal 13 ( 1 ) , art. no. 298

Pellis, L., Ball, F., Bansal, S., Eames, K., House, T., Isham, V., Trapman, P. (2014) Eight challenges for network epidemic models. Epidemics.

Truscott, J.E., Déirdre Hollingsworth, T., Brooker, S.J., Anderson, R.M. (2014) Can chemotherapy alone eliminate the transmission of soil transmitted helminths? Parasites and Vectors 7 art. no. 266

Gortazar, C., Reperant, L.A., Kuiken, T., de la Fuente, J., Boadella, M., Martínez-Lopez, B., Ruiz-Fons, F., Estrada-Peña, A., Drosten, C., Medley, G., Ostfeld, R., Peterson, T., VerCauteren, K.C., Menge, C., Artois, M., Schultsz, C., Delahay, R., Serra-Cobo, J., Poulin, R., Keck, F., Aguirre, A.A., Henttonen, H., Dobson, A.P., Kutz, S., Lubroth, J., Mysterud, A. (2014) Crossing the Interspecies Barrier: Opening the Door to Zoonotic Pathogens. PLoS Pathogens 10 art. no. e1004129

Fraser, C., Lythgoe, K., Leventhal, G.E., Shirreff, G., Hollingsworth, T.D., Alizon, S., Bonhoeffer, S. (2014) Virulence and pathogenesis of HIV-1 infection: An evolutionary perspective. Science, 343 ( 6177 ) , art. no. 1243727

Agoti, C.N., Mayieka, L.M., Otieno, J.R., Ahmed, J.A., Fields, B.S., Waiboci, L.W., Nyoka, R., Eidex, R.B., Marano, N., Burton, W., Montgomery, J.M., Breiman, R.F., Nokes, D.J. (2014) Examining strain diversity and phylogeography in relation to an unusual epidemic pattern of respiratory syncytial virus (RSV) in a long-term refugee camp in Kenya. BMC Infectious Diseases 14 art no 178

Inglis, N.J., Bagnall, H., Janmohamed, K., Suleman, S., Awofisayo, A., De Souza, V., Smit, E., Pebody, R., Mohamed, H., Ibbotson, S., Smith, G.E., House, T., Olowokure, B. (2014) Measuring the effect of influenza A(H1N1)pdm09: the epidemiological experience in the West Midlands, England during the 'containment' phase. Epidemiology and infection 142 428 - 437