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The Zeeman Institute

David Rand

Professor of Mathematics
Warwick Mathematics Institute

Office: MSB 5.08

Email: d.a.rand@warwick.ac.uk

Webpage: www.davidrand.uk

Portrait of David Rand

Research interests:

  • Developmental biology
  • Circadian clocks in health and disease (notably cancer)

Selected publications:

  • Vlachou D, Veretennikova M, Usselmann L, Vasilyev V, Ott S, Bjarnason GA, et al. (2024) TimeTeller: A tool to probe the circadian clock as a multigene dynamical system. PLoS Comput Biol 20(2): e1011779. https://doi.org/10.1371/journal.pcbi.1011779
  • M. Saez, J. Briscoe, D.A. Rand, 2022 . Dynamical landscapes of cell fate decisions. Interface Focus, 12(4), p.20220002https://doi.org/10.1098/rsfs.2022.0002

  • David A. Rand, Archishman Raju, Meritxell Sáez, Francis Corson, and Eric D. Siggia. Geometry of Gene Regulatory Dynamics. http://arxiv.org/abs/2105.13722 Proceedings of the National Academy of Sciences of the USA. (2021) 118:38:e2109729118 https://doi.org/10.1073/pnas.2109729118

  • M. Sáez, R. Blassberg, E. Camacho-Aguilar, E. D. Siggia, D. A. Rand*, J. Briscoe. Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions . Cell Systems 12:1–17 https://doi.org/10.1016/j.cels.2021.08.013 *Communicating author.
  • Elena Camacho-Aguilar, Aryeh Warmflash, David A. Rand. Quantifying cell transitions in C. elegans with data-fitted landscape models. PLoS Computational Biology, 17(6), p.e1009034.

Selected research:

Developmental biology

the topology and dynamics of cellular decision making in the early embryo, early development of the neural system, early development of the heart, somitogenesis. Collaborators include James Briscoe (Crick Institute), Eric Siggia (Rockefeller), Ina Sonnen (Hubrecht Institute), Paul Francois (Montreal), Tim Saunders (Warwick Medical School), Meritxell Saez (IQS Universitat Ramon Llull), Marine Fontaine (Warwick Maths).

Circadian clocks in health and disease (notably cancer)

algorithms providing a biomarker for the health of the circadian clock and a prognostic biomarker for survival in breast cancer. Collaborators include Francis Levi (Medical Oncology, Paul Brousse Hospital, Paris), Robert Dallmann (Warwick Medical School), Sylvie Giacchetti (Assistance Publique-Hopitaux de Paris), Georg A. Bjarnason (Odette Cancer Centre, Toronto), Vadim Vasilyev (Warwick Medical School).