Professor Sascha Ott - Recent Publications
“Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules controlling vertebrate organogenesis”, Daniela M. Figiel, Randa Elsayed, Mark D. Walsh, Simaran Johal, Ying Lin, Till Bretschneider, Sascha Ott, Andrew C. Nelson, bioRxiv, 2025
“Stalling of the endometrial decidual reaction determines the recurrence risk of miscarriage“, Joanne Muter, Chow-Seng Kong, Mireia Taus Nebot, Maria Tryfonos, Pavle Vrljicak, Paul J. Brighton, Danai B. Dimakou, Megan Vickers, Hiroyuki Yoshihara, Sascha Ott, Bee K. Tan, Phillip R. Bennett, Siobhan Quenby, Alex Richter, Hilde Van de Velde, Emma S. Lucas, Thomas M. Rawlings, Jan J. Brosens, bioRxiv, 2024
“Comparison and combination of mutation and methylation-based urine tests for bladder cancer detection”, Naheema S. Gordon, Elspeth K. McGuigan, Michaela Ondasova, Jennifer Knight, Laura A. Baxter, Sascha Ott, Robert K. Hastings, Maurice P. Zeegers, Nicholas D. James, K. K. Cheng, Anshita Goel, Minghao Yu, Roland Arnold, Richard T. Bryan, Douglas G. Ward, Biomarker Research, 12: 133, 2024
“EnteroBase in 2025: exploring the genomic epidemiology of bacterial pathogens”, Nigel P Dyer, Birgitta Päuker, Laura Baxter, Anshul Gupta, Boyke Bunk, Jörg Overmann, Margo Diricks, Viola Dreyer, Stefan Niemann, Kathryn E Holt, Mohammed Rahman, Paul E Brown, Richard Stark, Zhemin Zhou, Sascha Ott, Ulrich Nübel, Nucleic Acids Research, accepted, 2024
“The chromatin landscape of high-grade serous ovarian cancer metastasis identifies regulatory drivers in post-chemotherapy residual tumour cells”, Wayne Croft, Rachel Pounds, David Jeevan, Kavita Singh, Janos Balega, Sudha Sundar, Anthony Williams, Raji Ganesan, Sean Kehoe, Sascha Ott, Jianmin Zuo, Jason Yap, Paul Moss, Communications Biology, 7: 1211, 2024
“Single-cell analysis identifies distinct macrophage phenotypes associated with prodisease and proresolving functions in the endometriotic niche”, Yasmin Henlon, Kavita Panir, Iona McIntyre, Chloe Hogg, Priya Dhami, Antonia O. Cuff, Anna Senior, Niky Moolchandani-Adwani, Elise T. Courtois, Andrew W. Horne, Matthew Rosser, Sascha Ott, Erin Greaves, PNAS, 121: e2405474121, 2024
“Centralized industrialization of pork in Europe and America contributes to the global spread of Salmonella enterica”, Heng Li, Yilei Wu, Dan Feng, Quangui Jiang, Shengkai Li, Jie Rong, Ling Zhong, Ulrich Methner, Laura Baxter, Sascha Ott, Daniel Falush, Zhenpeng Li, Xiangyu Deng, Xin Lu, Yi Ren, Biao Kan, Zhemin Zhou, Nature Food, doi.org/10.1038/s43016-024-00968-1, 2024
press release
“Analysis of single nuclear chromatin accessibility reveals unique myeloid populations in human pancreatic ductal adenocarcinoma”, Hillary G. Pratt, Li Ma, Sebastian A. Dziadowicz, Sascha Ott, Thomas Whalley, Barbara Szomolay, Timothy D. Eubank, Gangqing Hu, Brian A. Boone, Clinical and Translational Medicine, 14: e1595, 2024
“TimeTeller: A tool to probe the circadian clock as a multigene dynamical system”, Denise Vlachou , Maria Veretennikova, Laura Usselmann , Vadim Vasilyev, Sascha Ott, Georg A. Bjarnason, Robert Dallmann, Francis Levi, David A. Rand, PLOS Computational Biology, 20: e1011779, 2024
"Dynamic chromatin remodeling in cycling human endometrium at single-cell level”, Pavle Vrljicak, Emma S. Lucas, Maria Tryfonos, Joanne Muter, Sascha Ott, Jan J. Brosens, Cell Reports, 42: 113525, 2023
“Rhizobial nitrogen fixation efficiency shapes endosphere bacterial communities and Medicago truncatula host growth”, Beatriz Lagunas, Luke Richards, Chrysi Sergaki, Jamie Burgess, Alonso Javier Pardal, Rana M.F. Hussain, Bethany L. Richmond, Laura Baxter, Proyash Roy, Anastasia Pakidi, Gina Stovold, Saúl Vázquez, Sascha Ott, Patrick Schäfer, Miriam L. Gifford, Microbiome, 11: 146, 2023
“Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency”, Christopher B. Mahony, Lucy Copper, Pavle Vrljicak, Boris Noyvert, Chrystala Constantinidou, Sofia Browne, Yi Pan, Claire Palles, Sascha Ott, Martin R. Higgs, Rui Monteiro, Cell Reports, 42: 112571, 2023
“Properties of non-coding mutation hotspots as urinary biomarkers for bladder cancer detection”, L. Baxter, N.S. Gordon, S. Ott, J. Wang, P. Patel, A. Goel, K. Piechocki, L. Silcock, C. Sale, M.P. Zeegers, K.K. Cheng, N.D. James, The BladderPath trial management group, R.T. Bryan, D.G. Ward, Scientific Reports, 13: 1060, 2023
“Epigenetic priming of immune/inflammatory pathways activation and abnormal activity of cell cycle pathway in a perinatal model of white matter injury”, Anne-Laure Schang, Juliette Van Steenwinckel, Zoi S. Ioannidou, Julia Lipecki, Charlotte Rich-Griffin, Kate Woolley-Allen, Nigel Dyer, Tifenn Le Charpentier, Patrick Schäfer, Bobbi Fleiss, Sascha Ott, Délara Sabéran-Djoneidi, Valérie Mezger, Pierre Gressens, Cell Death & Disease, 13: 1038, 2022
"Highly Sensitive and Specific Detection of Bladder Cancer via Targeted Ultra-deep Sequencing of Urinary DNA”, Douglas G Ward, Laura Baxter, Sascha Ott, Naheema S Gordon, Junhui Wang, Prashant Patel, Kim Piechocki, Lee Silcock, Chris Sale, Maurice P Zeegers, K K Cheng, Nicholas D James, Richard T Bryan, BladderPath Trial Management Group, European Urology Oncology, 6: 67-75, 2022
“Immediate perturbation of DNA methylation upon acute prenatal alcohol exposure in the mouse developing brain cortex”, Agathe Duchateau, Névé Auperin, Federico Miozzo, Anne Le Mouel, Olivier Kirsh, Myriame Mohamed, Sascha Ott, Délara Saberan-Djoneidi, Valérie Mezger, bioRxiv, 2022
“EndoTime: Non-categorical timing estimates for luteal endometrium”, Julia Lipecki, Andrew E Mitchell, Jo Muter, Emma S Lucas, Komal Makwana, Katherine Fishwick, Joshua Odendaal, Amelia Hawkes, Pavle Vrljicak, Jan J Brosens, Sascha Ott, Human Reproduction, 37: 747–761, 2022
“Macrophage and Neutrophil Interactions in the Pancreatic Tumor Microenvironment Drive the Pathogenesis of Pancreatic Cancer”, Hillary G Pratt, Kayla J Steinberger, Nicole E Mihalik, Sascha Ott, Thomas Whalley, Barbara Szomolay, Brian A Boone, Timothy D Eubank, Cancers, 14: 194, 2022