Imaging technologies play a big part in quantitative approaches to biology. The two main drivers in this rapidly evolving field are fluorescent probes to label and image cellular constituents in live cells, and computerised, fast, and high-resolution microscopes. Warwick’s Advanced Imaging Research Techology Platform provides access to state-of-the-art light-sheet microscopy, enabling ultra-fast 3D optical sectioning of live specimen. Researchers at Warwick Medical School are at the forefront of developing novel superresolution and single molecule microscopy techniques.
At the Zeeman Institute research in imaging focuses on:
- Automated image analysis of complex time series data obtained by live cell fluorescence microscopy
- Fitting of mathematical and biophysical models to image data in order to investigate non-linear cellular dynamics
- Cell movement
- Cell membrane dynamics
- Oscillatory dynamics of transcription factors
- Mechanics of cell division
- Mechanics and signal propagation in tissues
- QuimP: Measuring fluorescent signals at the membrane of moving cells
- LineageTracker: Tracking cell nuclei in large populations of cells, assembly of cell lineages
- CellTracker: Measuring nucleocytoplasmic translocations of transcription factors
- KiT: Kinetochore tracking
People involved in imaging research at the Zeeman Institute, with selected publications:
Collier S, Paschke P, Kay RR, Bretschneider T.
Sci Rep. 2017 Jul 27;7(1):6692. doi: 10.1038/s41598-017-06875-9.