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Refereed Publications

See also Warwick Research Archive Portal WRAP for pre- & post-prints; ORCID & Figshare for other publications

A chemical genomics approach to drug reprofiling in oncology: Antipsychotic drug risperidone as a potential adenocarcinoma treatment. Suzanne J. Dilly, Andrew J. Clark, Andrew Marsh, Daniel A. Mitchell, Ricky Cain, Colin W. G. Fishwick, Paul C. Taylor Cancer Letters, 2017, 393, 16-21.

Co-existence of Distinct Supramolecular Assemblies in Solution and in the Solid State. G. N. Manjunatha Reddy, Aida Huqi, Dinu Iuga, Satoshi Sakurai, Andrew Marsh, Jeffery T. Davis, Stefano Masiero, and Steven P. Brown Chem. Eur. J. 2016, doi:10.1002/chem.201604832. (VIP article and cover illustration).

Fast Magic-Angle Spinning Three-Dimensional NMR Experiment for Simultaneously Probing H—H and N—H Proximities in Solids. G. N. Manjunatha Reddy, Michael Malon, Andrew Marsh, Yusuke Nishima and Steven P. Brown Analytical Chemistry, 2016, 88, 11412-11419. doi:10.1021/acs.analchem.6b01869.

Kinetic Characterisation of a Single Chain Antibody against the Hormone Abscisic Acid: Comparison with Its Parental Monoclonal G O Badescu, A Marsh, T R Smith, A J Thompson, R M Napier PLOS ONE 2016, doi:10.1371/journal.pone.0152148

Simvastatin sodium salt and fluvastatin interact with human gap junction gamma-3 protein A Marsh,* K Casey-Green, F Probert, D Withall, D A Mitchell, S J Dilly, S James, W Dimitri, S R Ladwa, P C Taylor, D R J Singer PLOS ONE 2016, DOI: 10.1371/journal.pone.0148266

Interplay of Noncovalent Interactions in Ribbon-like Guanosine Self-Assembly: An NMR Crystallography Study. G. N. Manjunatha Reddy, Andrew Marsh, Jeffery T. Davis, Stefano Masiero, Steven P. Brown* Cryst. Growth Des., 2015, 15, 5945–5954 DOI: 10.1021/acs.cgd.5b01440

The use of a selective saturation pulse to suppress t1 noise in two-dimensional 1H fast magic angle spinning solid-state NMR spectroscopy. A J Robertson, M K Pandey, A Marsh, Y Nishiyama, S P Brown J. Magn. Res. 2015, 260, 89 - 97 doi:10.1016/j.jmr.2015.09.005 

G4-Quartet•M+ Borate Hydrogels. G M Peters, L P Skala, T N Plank, H Oh, G N M Reddy, A Marsh, S P Brown, S R Raghavan, and J T Davis* J. Am. Chem. Soc. 2015, 137, doi:10.1021/jacs.5b02753

Water soluble triblock and pentablock poly(methacryloyl nucleosides) from copper-mediated living radical polymerisation using PEG macroinitiators Margarita Garcia, Matthew P. Beecham, Kristian Kempe, David M. Haddleton, Afzal Khan, Andrew Marsh European Polymer Journal, 66, 444-451.

A NMR crystallography study of the hemihydrate of 2’, 3’-O-isopropylidineguanosine G. N. Manjunatha Reddy, Daniel S. Cook, Dinu Iuga, Richard I. Walton, Andrew Marsh, Steven P. Brown,* Solid State Nuclear Magnetic Resonance, 2015, doi:/10.1016/j.ssnmr.2015.01.001

Templated polymerizations on solid supports mediated by complementary nucleoside interactions. Margarita Garcia, Kristian Kempe, David M. Haddleton,* Afzal Khan and Andrew Marsh* Polymer Chem. 2015 DOI: 10.1039/c4py01783h.

A G4•K+ Hydrogel Stabilized by an Anion. Gretchen Marie Peters, Luke P. Skala, Taylor N. Plank, Brooke J. Hyman, G. N. Manjunatha Reddy, Andrew Marsh, Steven P. Brown, and Jeffery T. Davis* J. Am. Chem. Soc. 2014, 136, 12596−12599.

Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation. Millard, A.; Scanlan, D. J.;* Gallagher, C.; Marsh, A.; Taylor, P. C.* Molecular BioSystems 2014 10, 380 – 383. DOI: 10.1039/C3MB70447E

Use of freely available and open source tools for in silico screening in Chemical Biology. G Price, P S Gould, A Marsh J. Chem. Educ., 2014 doi.10.1021/ed400302u.

A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins Taylor, PC; Clark, AJ; Marsh, A ; Singer, DRJ; Dilly, SJ Chem. Commun. 2013, 49, 9588 - 9590 DOI: 10.1039/c3cc44647f.

Nanostructures from tertiary amine N-oxide amphiphiles: M P Beecham, G J Clarkson, G Hall, A Marsh ChemPhysChem, 2013, DOI: 10.1002/cphc.201300775.

A chemical genomics approach to identification of interactions between bioactive molecules and alternative reading frame proteins. P C Taylor,* A J Clark, A Marsh, D R J Singer, S J Dilly Chem. Commun., 2013, DOI: 10.1039/c3cc44647f.

Oxidation of Tertiary Amine-Derivatized Surfaces To Control Protein Adhesion: D. A. Dobrzanska, A. L. Cooper, C. G. Dowson, S. D. Evans, D. J. Fox, B. R. Johnson, C. I. Biggs, R. K. Randev, H. M. Stec, P. C. Taylor, A. Marsh Langmuir, 2013, 29, 2961–2970 DOI: 10.1021/la4003719

An optimized method for profiling glucosinolate content in Brassica enabling plant line selection and Quantitative Trait Locus mapping R Issa,* G Barker, A Marsh, S E Slade, P Taylor Intl J. Nutrition and Food Sci, 2013, 2, 10-16. doi:10.11648/j.ijnfs.20130201.13

Nanodiamond Promotes Surfactant-Mediated Triglyceride Removal from a Hydrophobic Surface at or below Room Temperature: Xianjin Cui, Xianping Liu, Andrew S. Tatton, Steven P. Brown, Haitao Ye, and Andrew Marsh.* ACS Appl. Mater. Interfaces 2012,

Challenges and solutions for personalizing medicines: D. R. J. Singer, A. Marsh Health Policy and Technology 2012, 1, 50-52. doi:10.1016/j.hlpt.2012.01.010

Using the DC-SIGN & Man9(GlcNAc)2 pairing to probe specificity in photochemical immobilization: S. J. Dilly, A. J. Clark, D. A. Mitchell, A. Marsh, P. C. Taylor: Mol. Biosyst. 2011, 7, 116-118 doi:10.1039/C0MB00118J

Personalized medicine - the impact on chemistry: J. Watkins, A. Marsh, P. C. Taylor, D. R. J. Singer: Therapeutic Delivery 2010, 1, 651-665. Pre-print here.

Apparent non-statistical binding in a ditopic receptor for guanosine: A Likhitsup, R J Deeth, S Otto, A Marsh* Org. Biomol. Chem. 2009, DOI: 10.1039/B812969j. Supporting information on Figshare 2:1 alkyne 1:1 C-alkyne-C receptor self-association 1:1 C-dialkyne-C receptor self-association, 2:1 dialkyne, guanosine self-association.

Rapid Identification of a Putative Interaction between β2-Adrenoreceptor Agonists and ATF4 using a Chemical Genomics Approach: S. R. Ladwa, S. J. Dilly, A. J. Clark, A. Marsh, P. C. Taylor ChemMedChem, 2008, 3, 742-744. DOI:10.1002/cmdc.200700317

Featured cover art. DOI: 10.1002/cmdc.200890018.

A photoimmobilisation strategy that maximises exploration of chemical space in small molecule affinity selection and target discovery: S. J. Dilly, M. J. Bell, A. J. Clark, A. Marsh, R. M. Napier, M. J. Sergeant, A. J. Thompson, P. C. Taylor Chem. Commun. 2007, 2808-2810. DOI: 10.1039/B704271J

Function and Stability of Abscisic Acid Acyl Hydrazone Conjugates by LC-MS2 of ex vivo Samples: T R Smith, A J Clark, A, R M Napier, P C Taylor, A J Thompson, A Marsh* Bioconjugate Chemistry, 2007, 1355-1359. DOI: 10.1021/bc070069x

Concise Enantioselective Synthesis of Abscisic Acid and a New Analogue: T. R. Smith, A. J. Clark, G. J. Clarkson, P. C. Taylor, A. Marsh Org. Biomol. Chem. 2006, 4, 4186. doi:10.1039/B611880A

Novel tertiary amine oxide surfaces that resist nonspecific protein adsorption, S. J. Dilly, M. P. Beecham, S. P. Brown, J. M. Griffin, A. J. Clark, C. D. Griffin, J. Marshall, R. M. Napier, P. C. Taylor, A. Marsh, Langmuir 2006, 22, 8144-8150. DOI: 10.1021/la060743j

Practical syntheses of [1,3,5]-triazine dendritic molecules on solid supports, S. J. Dilly, S. J. Carlisle, A. J. Clark, A. R. Shepherd, S. C. Smith, P. C. Taylor, A. Marsh, Journal of Polymer Science Part a-Polymer Chemistry 2006, 44, 2248-2259. DOI: 10.1002/pola.21336

Synthesis of novel nucleo-beta-amino acids and nucleobase-functionalized beta-peptides, A. M. Bruckner, M. Garcia, A. Marsh, S. H. Gellman, U. Diederichsen, European Journal of Organic Chemistry 2003, 3555-3561. DOI: 10.1002/ejoc.200300269

Synthesis and characterisation of new ditopic receptors for guanosine, A. Marsh, N. W. Alcock, W. Errington, R. Sagar, Tetrahedron 2003, 59, 5595-5601. doi:10.1016/S0040-4020(03)00708-7

Interfacing supramolecular and macromolecular chemistry: metallo-supramolecular triple-helicates incorporated into polymer networks, A. Lavalette, J. Hamblin, A. Marsh, D. M. Haddleton, M. J. Hannon, Chemical Communications 2002, 3040-3041. DOI: 10.1039/B210019C

High-loading scavenger resins for combinatorial chemistry, A. Marsh, S. J. Carlisle, S. C. Smith, Tetrahedron Letters 2001, 42, 493-496. doi:10.1016/S0040-4039(00)01999-7

The effect of electrolyte concentration on the chemical force titration behavior of omega-functionalized SAMs: Evidence for the formation of strong ionic hydrogen bonds, D. A. Smith, M. L. Wallwork, J. Zhang, J. Kirkham, C. Robinson, A. Marsh, M. Wong, Journal of Physical Chemistry B 2000, 104, 8862-8870. DOI: 10.1021/jp0023056

Copper(I) mediated radical polymerisation of uridine and adenosine monomers on a silica support, A. Marsh, A. Khan, M. Garcia, D. M. Haddleton, Chemical Communications 2000, 2083-2084. DOI: 10.1039/B005832G

Improved preparation and application of poly(ethylene glycol) vinyl sulfone, A. Khan, A. Marsh, Synthetic Communications 2000, 30, 2599-2608. DOI:10.1080/00397910008087425

Determination of the ionization state of 11-thioundecyl-1-phosphonic acid in self-assembled monolayers by chemical force microscopy, J. Zhang, J. Kirkham, C. Robinson, M. L. Wallwork, D. A. Smith, A. Marsh, M. Wong, Analytical Chemistry 2000, 72, 1973-1978. DOI: 10.1021/ac9913107

Atom transfer polymerization: Use of uridine and adenosine derivatized monomers and initiators, A. Marsh, A. Khan, D. M. Haddleton, M. J. Hannon, Macromolecules 1999, 32, 8725-8731. DOI: 10.1021/ma991438q

Hydrogen bond template-directed polymerization of protected 5 '-acryloylnucleosides, A. Khan, D. M. Haddleton, M. J. Hannon, D. Kukulj, A. Marsh, Macromolecules 1999, 32, 6560-6564. DOI: 10.1021/ma990283j

Postdoctoral Studies, Centre for Self Organising Molecular Systems, University of Leeds

Attenuated total reflection Fourier transform infrared spectroscopic characterization of fluid lipid bilayers tethered to solid supports, Y. L. Cheng, N. Boden, R. J. Bushby, S. Clarkson, S. D. Evans, P. F. Knowles, A. Marsh, R. E. Miles, Langmuir 1998, 14, 839-844.

Kinetics of formation of single phospholipid bilayers on self-assembled monolayer supports, as monitored by surface plasmon resonance, L. M. Williams, S. D. Evans, T. M. Flynn, A. Marsh, P. F. Knowles, R. J. Bushby, N. Boden, Supramolecular Science 1997, 4, 513-517.

The design and synthesis of simple molecular tethers for binding biomembranes to a gold surface, N. Boden, R. J. Bushby, S. Clarkson, S. D. Evans, P. F. Knowles, A. Marsh, Tetrahedron 1997, 53, 10939-10952.

Kinetics of the unrolling of small unilamellar phospholipid vesicles onto self-assembled monolayers, L. M. Williams, S. D. Evans, T. M. Flynn, A. Marsh, P. F. Knowles, R. J. Bushby, N. Boden, Langmuir 1997, 13, 751-757.

Postdoctoral Studies with Professor Jean-Marie Lehn, Université Louis Pasteur, Strasbourg

Self-complementary hydrogen bonding heterocycles designed for the enforced self-assembly into supramolecular macrocycles, A. Marsh, M. Silvestri, J. M. Lehn, Chemical Communications 1996, 1527-1528.

Mesoscopic Supramolecular Assembly of a Janus Molecule and a Melamine Derivative Via Complementary Hydrogen-Bonds, N. Kimizuka, S. Fujikawa, H. Kuwahara, T. Kunitake, A. Marsh, J. M. Lehn, Journal of the Chemical Society-Chemical Communications 1995, 2103-2104.

Janus Molecules - Synthesis of Double-Headed Heterocycles Containing 2 Identical Hydrogen-Bonding Arrays, A. Marsh, E. G. Nolen, K. M. Gardinier, J. M. Lehn, Tetrahedron Letters 1994, 35, 397-400.

PhD with Professor Donald Craig, Imperial College

Vitamin D-3 synthetic studies. Intramolecular Diels-Alder approaches to the CD-ring fragment, M. C. Clasby, D. Craig, A. A. JaxaChamiec, J. Y. Q. Lai, A. Marsh, A. M. Z. Slawin, A. J. P. White, D. J. Williams, Tetrahedron 1996, 52, 4769-4802.

Vitamin-D(3) Synthetic Studies - Enantiospecific Synthesis of the CD Ring Fragment, M. C. Clasby, D. Craig, A. Marsh, Angewandte Chemie-International Edition in English 1993, 32, 1444-1446.

A Novel One-Pot Synthesis of Vinylic Sulphoxides: Craig, D.; Daniels, K.; Marsh, A.; Rainford, D.; Smith, A. M. Synlett, 1990, 531.

Intramolecular Diels-Alder Reactions of Sulfonyl-Substituted Trienes, D. Craig, D. A. Fischer, O. Kemal, A. Marsh, T. Plessner, A. M. Z. Slawin, D. J. Williams, Tetrahedron 1991, 47, 3095-3128.

Undergraduate (Placement Student, SmithKline Beecham)

An Unexpected Aromatic SN2' Substitution of a 4-Bromobenzopyran, C. S. V. Houge-Frydrych, A. Marsh, I. L. Pinto, Journal of the Chemical Society-Chemical Communications 1989, 1258-1259.

Conference Abstracts

Polymer-supported bifunctional reagents for catalysis, C. Wood, A. Marsh, J. W. Davies, Abstracts of Papers of the American Chemical Society 2005, 229, U357-U357.

Atom-transfer polymerization: Use of uridine- and adenosine-derivatized monomers and initiators, A. Marsh, A. Khan, D. M. Haddleton, M. J. Hannon, Abstracts of Papers of the American Chemical Society 2000, 219, U426-U426.

Novel polymers from atom transfer polymerisation mediated by copper(I) Schiff base complexes, D. M. Haddleton, A. M. Heming, A. P. Jarvis, A. Khan, A. Marsh, S. Perrier, S. A. F. Bon, S. G. Jackson, R. Edmonds, E. Kelly, D. Kukulj, C. Waterson, Macromolecular Symposia 2000, 157, 201-208.

Hydrogen bond template-directed polymerization of protected 5 '-acryloylnucleosides, A. Marsh, D. M. Haddleton, M. J. Hannon, A. Khan, D. Kukulj, Abstracts of Papers of the American Chemical Society 1999, 218, U485-U485.

Reports and Other Publications

Report on BPS Drug Discovery Pathways Symposium 2014. A Marsh