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Chemistry Rebecca Notman Group

Publications

  • Mechaisms of the Drug Penetration Enhancer Propylene Glycol Interacting with Skin Lipid Mebranes, Mistry, J. and Notman, R., J. Phys. Chem. B, 2024. https://doi.org/10.1021/acs.jpcb.3c06784

  • Synthesis and Functionalization of Azetidine-Containing Small Macrocyclic Peptides, Saunders, G. J., Spring, S. A., Jayawant, E. J., Wilkening, I., Roesner, S., Clarkson, G. J., Dixon, A. M., Notman, R. and Shipman, M., Chemistry A European Journal, 2024, e202400308. https://doi.org/10.1002/chem.202400308

  • Impact of oxetane incorporation on the structure and stability of alpha-helical peptides, ES Jayawant, JD Beadle, I Wilkening, P Raubo, M Shipman, R Notman and AM Dixon, Phys. Chem. Chem. Phys., 2020, 22, 25075-25083 (abstract).
  • Comparison of umbrella sampling and steered molecular dynamics methods for computing free energy profiles of aromatic substrates through phospholipid bilayers, SY Noh and R Notman, J. Chem. Phys., 2020, 153, 034115 (abstract).
  • The aggregation of striped nanoparticles in mixed phospholipid bilayers, SY Noh, A Nash and R Notman, Nanoscale, 2020, 12, 4868-4881 (abstract).
  • Macrocyclisation of small peptides enabled by oxetane incorporation, S Roesner, GJ Saunders, I Wilkening, E Jayawant, JV Geden, P Kerby, AM Dixon, R Notman and M Shipman, Chem. Sci., 2019, 10, 2465-2472 (abstract).
  • Permeation Pathways through Lateral Domains in Model Membranes of Skin Lipids, A Del Regno and R Notman, Phys. Chem. Chem. Phys., 2018, 20, 2162-2174 (abstract).
  • T-shaped Peptide Amphiphiles Self Assemble into Nanofiber Networks. FA Fisusi, R Notman, LA Granger, JP Malkinson, AG Schätzlein and IF Uchegbu, Pharmaceutical Nanotechnology, 2017, 5, 215-219 (abstract).
  • Synthesis of star-branched poly (vinyl alcohol) and ice recrystallization inhibition activity, TR Congdon, R Notman and MI Gibson, European Polymer Journal, 2017, 88, 320-327 (abstract).
  • Influence of Block Copolymerization on the Antifreeze Protein Mimetic Ice Recrystallization Inhibition Activity of Poly (vinyl alcohol),
    TR Congdon, R Notman and MI Gibson, Biomacromolecules, 2016, 17, 3033-3039 (abstract).
  • Probing the biomimetic ice nucleation inhibition activity of poly (vinyl alcohol) and comparison to synthetic and biological polymers,
    T Congdon, BT Dean, J Kasperczak-Wright, CI Biggs, R Notman and MI Gibson, Biomacromolecules, 2015, 16, 2820-2826 (abstract).
  • Computer Simulations of Lipid Membranes and Liposomes for Drug Delivery, DW O’Neill, SY Noh and R Notman, Computational Pharmaceutics: Application of Molecular Modelling in Drug Delivery, 2015 (abstract).
  • De novo design of transmembrane helix–helix interactions and measurement of stability in a biological membrane, A Nash, R Notman and AM Dixon,
    Biochimica et Biophysica Acta (BBA)-Biomembranes, 2015, 1848, 1248-1257 (abstract).
  • Complete structure of an epithelial keratin dimer: implications for intermediate filament assembly, DJ Bray, TR Walsh, MG Noro and R Notman, PloS one, 2015, 10, 1 (abstract and full text).
  • Ethanol induces the formation of water-permeable defects in model bilayers of skin lipids, R Thind, DW O'Neill, A Del Regno and R Notman, Chemical Communications, 2015, 51, 5406-5409 (abstract).
  • Powell, N. H., Clarkson, G. J., Notman, R., Raubo, P., Martin, N. G. and Shipman, M. (2014) Synthesis and structure of oxetane containing tripeptide motifs. Chem. Comm., 50, 8797 (abstract).
  • Thake, T. H. F., Webb, J. R., Nash, A., Rappoport, J. Z. and Notman, R. (2013) Permeation of Polystyrene Nanoparticles across Model Lipid Bilayer Membranes. Soft Matter, 9, 10265 (abstract).
  • Congdon, T., Notman, R. and Gibson, M. I. (2013) Antifreeze (Glyco)protein Mimetic Behavior of Poly(vinyl alcohol): Detailed Structure Ice Recrystallization Inhibition Activity Study. Biomacromolecules, 14, 1578 (abstract).
  • Deller, R.C., Congdon, T., Sahid, M., Morgan, M., Vatish, M., Mitchell, D.A., Notman, R., Gibson, M.I. (2013) Ice Recrystallisation Inhibition by Polyols: Comparison of Molecular and Macromolecular Inhibitors and Role of Hydrophobic Units. Biomater. Sci., 1, 478 (abstract).
  • Mazza, M., Notman, R., Anwar, J., Rodger, A., Hicks, M., Parkinson, G., McCarthy, D., Daviter, T., Moger, J., Garrett, N., Mead, T., Briggs, M., Schatzein, A. G. and Uchegbu, I. F. (2013) Nanofibre-Based Delivery of Therapeutic Peptides to the Brain. ACS Nano, 7, 1016 (abstract).
  • Notman, R. and Anwar, J. (2013) Breaching the Skin Barrier - Insights from Molecular Simulation of Model Membranes. Adv. Drug Del. Rev., 65, 237 (abstract).
  • Beevers, A. J., Nash, A., Salazar-Cancino, M., Scott, D. J., Notman, R. and Dixon, A. M. (2012) Effects of the oncogenic V664E mutation on membrane insertion, structure and sequence-dependent interactions of the Neu transmembrane domain in micelles and model membranes: An integrated biophysical and simulation study. Biochemistry, 51, 2558 (abstract).
  • Parsons, P., Gilbert, S. J., Vaughan-Thomas, A., Sorrell, D. A., Notman, R., Bishop, M. Hayes, A. J., Mason, D. J. and Duance, V. C. (2011) Type IX Collagen Interacts with Fibronectin Providing an Important Molecular Bridge in Articular Cartilage, J. Biol. Chem. 286, 34986 (abstract).
  • Notman, R., Oren, E. E., Tamerler, C., Sarikaya, M., Samudrala, R. and Walsh, T. R. (2010) Solution Study of Engineered Quartz Binding Peptides using Replica Exchange Molecular Dynamics, Biomacromolecules 11, 3266 (abstract).
  • Oren, E. E., Notman, R., Won, K. I., Evans, J. S., Walsh, T. R., Samudrala, R., Tamerler, C. and Sarikaya, M. (2010) Probing the Molecular Mechanisms of Quartz-Binding Peptides, Langmuir 26, 11003 (abstract).
  • Friling, S., Notman, R. and Walsh, T. R. (2010) Probing diameter-selective solubilisation of carbon nanotubes by reversible cyclic peptides using molecular dynamics simulations, Nanoscale 2, 98 (abstract).
  • Notman, R. and Walsh, T. R. (2009) Molecular dynamics studies of the interactions of water and amino acid analogs with quartz surfaces, Langmuir 25, 1638 (abstract).
  • Notman, R., Anwar, J., Briels, W.J., Noro, M.G. and den Otter, W.K. (2008) Simulations of skin barrier function: Free energies of hydrophobic and hydrophilic transmembrane pores in ceramide bilayers, Biophys. J. 95, 4763 (abstract).
  • Notman, R., Noro, M.G. and Anwar, J. (2007) Interaction of oleic acid with dipalmitoylphosphatidylcholine (DPPC) bilayers simulated by molecular dynamics, J. Phys. Chem. B 111, 12748 (abstract).
  • Notman, R., den Otter, W.K., Noro, M.G., Briels, W.J. and Anwar, J. (2007) The permeability enhancing mechanism of DMSO in ceramide bilayers simulated by molecular dynamics, Biophys. J. 93, 2056 (abstract).
  • Notman, R., Noro, M.G, O'Malley, B. and Anwar, J. (2006) Molecular basis for dimethyl sulfoxide (DMSO) action on lipid membranes, J. Am. Chem. Soc. 128, 13982 (abstract).
  • O'Malley, B., Moore, D. J., Noro, M., Anwar, J., Notman R., Dauskhardt, R. and Bedford, E. (2005) Towards a mechanical model of skin: Insights into stratum corneum mechanical properties from hierarchial models of lipid organisation, In Mechanical Properties of Bioinspired and Biological Materials; Viney, C., Katti, K., Ulm, F. J., Hellmich, C., Eds.; Materials Research Society: Warrendale, 2005; Vol. 844, p 167-172 (abstract).