Scanning electrochemical cell microscopy (SECCM) is a robust and versatile scanning electrochemical probe microscopy technique that allows direct correlation of structure-activity at the nanoscale. SECCM utilizes a mobile droplet cell to investigate and visualize electrochemical activity at interfaces with high spatio-temporal resolution, while also providing topographical information. This article highlights diverse contemporary challenges in the field of single entity electrochemistry (SEE) tackled by the increasing uptake of SECCM globally. Various applications of SECCM in SEE are featured herein, including electrocatalysis, electrodeposition, corrosion science and materials science, with electrode materials spanning particles, polymers, 2D materials and complex polycrystalline substrates. The use of SECCM for patterning structures is also highlighted.