Professor Sascha Ott - Recent Publications
“Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules acting during vertebrate organogenesis”, Daniela M. Riley, Randa Elsayed, Mark D. Walsh, Simaran Johal, Ying Lin, Harry Walton, Till Bretschneider, Sascha Ott, Andrew C. Nelson, Genome Research, doi:10.1101/gr.280838.125, 2026
“The ubiquitin-proteasome system is an important driver of EBV-associated nasopharyngeal carcinoma progression: a meta-analysis of transcriptomic data“, Hana Ratnawati, Ardo Sanjaya, Aldrich Christiandy, Lawrence S Young, Sascha Ott, Scientific Reports, 2026
“Uncovering coordinated pathway interactions through gene co-differential expression in yeast”, Muhammad Ibtisam Nasar, Syed Sabih Ur Rehman, Sascha Ott, Mohammad Tauqeer Alam, Nucleic Acids Research, 54: gkaf1410, 2026
“Integrative systems biology approaches for analyzing microbiome dysbiosis and species interactions”, Syed Sabih Ur Rehman, Muhammad Ibtisam Nasar, Cristina S Mesquita, Souhaila Al Khodor, Richard A Notebaart, Sascha Ott, Sunil Mundra, Ramesh P Arasardanam, Khalid Muhammad, Mohammad Tauqeer Alam, Briefings in Bioinformatics, 26: bbaf323, 2025
“Stalling of the endometrial decidual reaction determines the recurrence risk of miscarriage”, Joanne Muter, Chow-Seng Kong, Mireia Taus Nebot, Maria Tryfonos, Pavle Vrljicak, Paul J. Brighton, Danai B. Dimakou, Megan Vickers, Hiroyuki Yoshihara, Sascha Ott, Bee K. Tan, Phillip R. Bennett, Siobhan Quenby, Alex Richter, Hilde Van de Velde, Emma S. Lucas, Thomas M. Rawlings, Jan J. Brosens, Science Advances, 11: eadv1988, 2025
coverage on BBC
“EnteroBase in 2025: exploring the genomic epidemiology of bacterial pathogens”, Nigel P Dyer, Birgitta Päuker, Laura Baxter, Anshul Gupta, Boyke Bunk, Jörg Overmann, Margo Diricks, Viola Dreyer, Stefan Niemann, Kathryn E Holt, Mohammed Rahman, Paul E Brown, Richard Stark, Zhemin Zhou, Sascha Ott, Ulrich Nübel, Nucleic Acids Research, 53: D757–D762, 2025
“Comparison and combination of mutation and methylation-based urine tests for bladder cancer detection”, Naheema S. Gordon, Elspeth K. McGuigan, Michaela Ondasova, Jennifer Knight, Laura A. Baxter, Sascha Ott, Robert K. Hastings, Maurice P. Zeegers, Nicholas D. James, K. K. Cheng, Anshita Goel, Minghao Yu, Roland Arnold, Richard T. Bryan, Douglas G. Ward, Biomarker Research, 12: 133, 2024
“The chromatin landscape of high-grade serous ovarian cancer metastasis identifies regulatory drivers in post-chemotherapy residual tumour cells”, Wayne Croft, Rachel Pounds, David Jeevan, Kavita Singh, Janos Balega, Sudha Sundar, Anthony Williams, Raji Ganesan, Sean Kehoe, Sascha Ott, Jianmin Zuo, Jason Yap, Paul Moss, Communications Biology, 7: 1211, 2024
“Single-cell analysis identifies distinct macrophage phenotypes associated with prodisease and proresolving functions in the endometriotic niche”, Yasmin Henlon, Kavita Panir, Iona McIntyre, Chloe Hogg, Priya Dhami, Antonia O. Cuff, Anna Senior, Niky Moolchandani-Adwani, Elise T. Courtois, Andrew W. Horne, Matthew Rosser, Sascha Ott, Erin Greaves, PNAS, 121: e2405474121, 2024
“Centralized industrialization of pork in Europe and America contributes to the global spread of Salmonella enterica”, Heng Li, Yilei Wu, Dan Feng, Quangui Jiang, Shengkai Li, Jie Rong, Ling Zhong, Ulrich Methner, Laura Baxter, Sascha Ott, Daniel Falush, Zhenpeng Li, Xiangyu Deng, Xin Lu, Yi Ren, Biao Kan, Zhemin Zhou, Nature Food, doi.org/10.1038/s43016-024-00968-1, 2024
press release
“Analysis of single nuclear chromatin accessibility reveals unique myeloid populations in human pancreatic ductal adenocarcinoma”, Hillary G. Pratt, Li Ma, Sebastian A. Dziadowicz, Sascha Ott, Thomas Whalley, Barbara Szomolay, Timothy D. Eubank, Gangqing Hu, Brian A. Boone, Clinical and Translational Medicine, 14: e1595, 2024
“TimeTeller: A tool to probe the circadian clock as a multigene dynamical system”, Denise Vlachou , Maria Veretennikova, Laura Usselmann , Vadim Vasilyev, Sascha Ott, Georg A. Bjarnason, Robert Dallmann, Francis Levi, David A. Rand, PLOS Computational Biology, 20: e1011779, 2024
"Dynamic chromatin remodeling in cycling human endometrium at single-cell level”, Pavle Vrljicak, Emma S. Lucas, Maria Tryfonos, Joanne Muter, Sascha Ott, Jan J. Brosens, Cell Reports, 42: 113525, 2023
“Rhizobial nitrogen fixation efficiency shapes endosphere bacterial communities and Medicago truncatula host growth”, Beatriz Lagunas, Luke Richards, Chrysi Sergaki, Jamie Burgess, Alonso Javier Pardal, Rana M.F. Hussain, Bethany L. Richmond, Laura Baxter, Proyash Roy, Anastasia Pakidi, Gina Stovold, Saúl Vázquez, Sascha Ott, Patrick Schäfer, Miriam L. Gifford, Microbiome, 11: 146, 2023
“Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency”, Christopher B. Mahony, Lucy Copper, Pavle Vrljicak, Boris Noyvert, Chrystala Constantinidou, Sofia Browne, Yi Pan, Claire Palles, Sascha Ott, Martin R. Higgs, Rui Monteiro, Cell Reports, 42: 112571, 2023
“Properties of non-coding mutation hotspots as urinary biomarkers for bladder cancer detection”, L. Baxter, N.S. Gordon, S. Ott, J. Wang, P. Patel, A. Goel, K. Piechocki, L. Silcock, C. Sale, M.P. Zeegers, K.K. Cheng, N.D. James, The BladderPath trial management group, R.T. Bryan, D.G. Ward, Scientific Reports, 13: 1060, 2023