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Publications

2021

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  • Lerner E, Barth A, et int. Weiss S. FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices. eLife. 10:e60416. doi: 10.7554/eLife.60416
  • Hepp C, Shiaelis N, Robb NC, Vaughan A, Matthews PC, Stoesser N, Crook D & Kapanidis AN. Viral detection and identification in 20 minutes by rapid single-particle fluorescence in-situ hybridization of viral RNA. Scientific Reports. 11(1):19579. doi: 10.1038/s41598-021-98972-z

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2020
  • Shiaelis N, Tometzki A, Peto L, McMahon A, Hepp C, Bickerton E, Favard C , Muriaux D, Andersson M, Oakley S, Vaughan A, Matthews PC, Stoesser N , Crook D, Kapanidis AN & Robb NC. Virus detection and identification in minutes using single-particle imaging and deep learning. MedRxiv. https://www.medrxiv.org/content/10.1101/2020.10.13.20212035v1 

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  • McMahon A & Robb NC. Reinfection with SARS-CoV-2: Discrete SIR (Susceptible, Infected, Recovered) Modeling Using Empirical Infection Data. JMIR Public Health Surveill. 6(4):e21168. doi: 10.2196/21168

2019
  • Robb NC, Taylor JM, Kent A, Pambos O, Gilboa B, Kapanidis AN. Rapid functionalisation and detection of viruses via a novel Ca2+-mediated virus-DNA interaction. Scientific Reports. 9(1):16219. doi: 10.1038/s41598-019-52759-5

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  • Robb NC, te Velthuis AJW, Fodor E, Kapanidis AN. Real-time analysis of single influenza virus replication complexes reveals large promoter-dependent differences in initiation dynamics. Nucleic Acids Research. 47(12):6466-6477. doi: 10.1093/nar/gkz313

2018
  • Hepp C & Robb NC. Coming together during viral assembly. Nature Reviews Microbiology. 16(12):721. doi: 10.1038/s41579-018-0102-4
  • Hellenkamp B, Schmid S, et int., Hugel T. Precision and accuracy of single-molecule FRET measurements-a multi-laboratory benchmark study. Nature Methods. 15(9):669-676. doi: 10.1038/s41592-018-0085-0
  • Duchi D, Gryte K, Robb NC, Morichaud Z, Sheppard C, Brodolin K, Wigneshweraraj S, Kapanidis AN. Conformational heterogeneity and bubble dynamics in single bacterial transcription initiation complexes. Nucleic Acids Research. 46(2):677-688. doi: 10.1093/nar/gkx1146

2016
  • Robb NC, te Velthuis AJW, Wieneke R, Tampè R, Cordes T, Fodor E, Kapanidis AN. Single-molecule FRET reveals the pre-initiation and initiation conformations of influenza virus promoter RNA. Nucleic Acids Research. 44(21):10304-10315. doi: 10.1093/nar/gkw884
  • Duchi D, Bauer DLV, Fernandez L, Evans G, Robb NC, Hwang LC, Gryte K, Tomescu A, Zawadski P, Morichaud Z, Brodolin K, Kapanidis AN. RNA polymerase pausing during initial transcription. Molecular Cell. 63(6):939-50. doi: 10.1016/j.molcel.2016.08.011
  • Te Velthuis AJW, Robb NC, Kapanidis AN, Fodor E. The role of the priming loop in Influenza A virus RNA synthesis. Nature Microbiology. 1:16029. doi: 10.1038/nmicrobiol.2016.29

2014
  • Tomescu AI*, Robb NC*, Hengrung N, Fodor E, Kapanidis AN. Single-molecule FRET reveals a corkscrew RNA structure for the polymerase-bound influenza virus promoter. PNAS. 111(32):E3335-42. doi: 10.1073/pnas.1406056111 (*Joint first authors)

2013
  • Robb NC*, Cordes T*, Hwang LC*, Gryte K, Duchi D, Craggs TD, Santoso Y, Weiss S, Ebright RH, Kapanidis AN. The transcription bubble of the RNA polymerase-promoter open complex exhibits conformational heterogeneity and millisecond-scale dynamics: implications for transcription start-site selection. J Mol Biol. 425(5):875-85. doi: 10.1016/j.jmb.2012.12.015 (*Joint first authors)

2012
  • Wise HM, Hutchinson EC, Jagger BW, Stuart, AD, Kang ZH, Robb NC, Kash JC, Fodor, E, Firth AE, Gog JR, Taubenberger JK and Digard P. Identification of a novel splice variant form of the influenza a virus M2 ion channel. PLoS Pathogens. 8(11): e1002998. doi: 10.1371/journal.ppat.1002998
  • Robb NC and Fodor E. The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein. J Gen Virol . 93(Pt 1):113-8. doi: 10.1099/vir.0.035485-0

2011
  • Robb NC, Chase G, Bier K, Vreede FT, Shaw P, Naffakh N, Schwemmle M, Fodor E. The influenza A NS1 protein interacts with the nucleoprotein of viral ribonucleoprotein complexes. J Virol. 85(10):5228-31. doi: 10.1128/JVI.02562-10

2010
  • Wang Z, Robb NC, Lenz E, Wolff T, FodorE, Pleschka S. Reassortment of the NS segment of an H7-type HPAIV affects its propagation by altering the regulation of viral RNA production and the anti-viral host response. J. Virol . 84(21):11323-35. doi: 10.1128/JVI.01034-10
  • Robb NC, Jackson D, Vreede FT and Fodor E. Splicing of influenza A virus NS1 mRNA is independent of the viral NS1 protein. J Gen Virol. 91(Pt 9):2331-40. doi: 10.1099/vir.0.022004-0
  • Chan W, Ng A, Robb NC, Lam M, Chan P, Au S, Fodor E, Shaw P. Functional analysis of influenza H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities. J. Virol . 84(14):7337-45. doi: 10.1128/JVI.02474-09
  • Rehwinkel J, Tan CP, Goubau D, Schulz O, Pichlmair A, Bier K, Robb NC, Vreede F, Barclay W, Fodor E, Reis e Sousa C. RIG-I detects viral genomic RNA during negative strand RNA virus infection. Cell. 140(3):397-408. doi: 10.1016/j.cell.2010.01.020

2009
  • Robb NC*, Smith M*, Vreede FT, Fodor E. (2009) The NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome. J Gen Virol. 90(Pt 6):139. (*Joint first authors). doi: 10.1099/vir.0.009639-0

Outreach articles

Aartjan te Velthuis & Nicole Robb

The Conversation, 2016.

Aartjan te Velthuis & Nicole Robb

World Economic Forum, 2016.

Nicole Robb

Oxplore, 2019.