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AIRWAYS-3: Randomised trial of a supraglottic airway device versus tracheal intubation during in-hospital cardiac arrest

The trial is recruiting, and continuing to set up new sites.


Cardiac Arrest CPD Webinar Instalment 3, 22nd January 2024 - Watch the recording HERELink opens in a new window


Trial Design

This is a multi-centre, open-label, pragmatic, individually randomised, parallel group, superiority trial and economic evaluation to determine the clinical and cost effectiveness of SGA versus TI during IHCA. The trial will be conducted in the acute setting in NHS hospitals throughout the UK.

An internal pilot study will confirm the feasibility of the trial. An integrated economic evaluation will assess the cost-effectiveness of SGA compared with TI.

The primary outcome is the Modified Rankin Scale (mRS) score assessed at hospital discharge or 30 days following IHCA, whichever occurs sooner.

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Chief Investigator: Professor Jonathan Benger

Sponsor: University Hospitals Bristol and Weston NHS Foundation Trust

Funder: National Institute for Health Research

Registration Number: ISRCTN17720457

Summary: Randomised trial of the clinical and cost effectiveness of a supraglottic airway device versus intubation during in-hospital cardiac arrest (Airways3)

The best way to keep a person’s airway open during a cardiac arrest has been thought to be placing a breathing tube in the windpipe (tracheal intubation). However, attempting to place a breathing tube can cause complications such as accidental placement in the oesophagus (food pipe) rather than the airway, tissue damage and interruptions in chest compressions.

It is possible that a newer method of airway management, inserting a supraglottic airway device, is better than tracheal intubation during cardiac arrest. Supraglottic airway devices are already used during routine anaesthesia in hospital; in emergency care, they are quicker to insert and cause less interruption to chest compressions.

Sample size:

4190 participants

Primary outcome:

Functional status at hospital discharge (or 30 days post-randomisation whichever is shorter) as measured by the modified Rankin Scale (mRS).


1 st January 2022 – 31 st December 2026

How are students assessed?

Students are required to complete a formative assessment at the end of each block. Students are given the right to sit summative assessments based on completion of formative assessments, engagement with the programme and attendance. Summative assessments are at the end of year one, end of year two and in the final year.

Can I park my car at the Medical School?

Due to the pressures on car parking capacity on campus it is not possible to provide dedicated parking for students. Students can access Pay-and-Display spaces and Pay-on-Foot car parks.Further information about parking on campus.

Can first year students apply for campus accommodation?

Yes, first year students are normally placed in Tocil with other Postgraduate students. There is also off campus Warwick Accommodation available.



Recruiting and sites in set up

39 sites open

Contact Trial Team



AIRWAYS-3 Trial Team
Warwick Clinical Trials Unit,
Warwick Medical School,
University of Warwick,

CTU Trial Team Members

Trial Manager - Chloe Norman

Trial Co-ordinator - Jannat Chowdhury

Data Entry Clerk - Laurilee Sprauve


Bristol Hospitals

Warwick CTU logo