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Completed Trials


Discover the trials WCTU has completed.

Completed trials

Trial name About the trial

Trial type

Chief Investigator
ACTIVATES Investigating whether an exercise programme is acceptable to patients, parents and physiotherapists and what training is required to deliver the treatments in NHS hospitals. (Published paper) Musculoskeletal Prof Sallie Lamb
AIR Assessing the difference in the Manchester-Oxford Foot and Ankle Questionnaire at six months after injury between adults with an ankle fracture treated with functional bracing and exercises versus standard plaster cast care. Musculoskeletal Prof Rebecca Kearney
Ancientbiotic Study Phase 1 safety trial of a natural product cocktail with antibacterial activity in human volunteers Other

Dr Freya Harrison

Prof Julie Bruce

ATM Comparing Platelet Rich Plasma (PRP) to placebo (imitation) injection in adults with Achilles tendon pain Surgery, Trauma & Orthopaedics Prof Rebecca Kearney
BALTI-2 Investigating whether salbutamol improves the health of patients with acute respiratory distress syndrome (ARDS). (Published Paper) Emergency and critical care Prof Fang Gao
BALTI-prevention Investigating the effectiveness of inhaled salmeterol for the prevention of acute lung Injury/Acute Respiratory Distress Syndrome (ARDS) in patients at high risk of developing the condition. (Published paper) Emergency and critical care Prof Gavin Perkins
Best A multi-centred randomised controlled trial of a primary-care based cognitive behavioural program for low back pain. (Published paper) Rehabilitation Prof Sallie lamb
Breathe Protocolised trial of invasive and non-invasive weaning off ventilation. Emergency and critical care Prof Gavin Perkins
CHESS Investigating the management of chronic headaches.


Prof Martin Underwood

DRAFFT A randomised controlled trial of percutaneous fixation with Kirschner wires versus volar locking-plate fixation in the treatment of adult patients with a dorsally displaced fracture of the distal radius Trauma and orthopaedics

Prof Matthew Costa

DAPA To answer the question: Does a programme of exercise and physical activity improve cognition for people with mild to moderate dementia? Frailty Prof Sallie Lamb
FASHIoN Designed to help decide on the best treatment for hip impingement so that we can care for you and others with hip impingement more effectively in the future. Trauma and orthopaedics Prof Damian Griffin
FIS Assessing the clinical and cost-effectiveness of facet joint injections compared to best usual non-invasive care in patients with persistent non-specific low back pain.(Published paper) Emergency and critical care Dr Harbinder Sandhu
FixDT Comparing intramedullary nail fixation with locking plate fixation for patients with a distal tibia fracture. Trauma and orthopaedics Prof Matthew Costa
HeFT To investigate whether surgery by open reduction and internal fixation provides benefit compared with non-operative treatment for displaced, intra-articular calcaneal fractures. (Published paper ) Trauma &Orthopaedic Prof Damian Griffin

Investigating the effect of using decision aid on available treatment options for patients with non specific chronic low back pain and their decision making process, on the patient's satisfaction levels.

(Published Paper)

Rehabilitation Prof Martin Underwood
I-WOTCH Improving the Wellbeing of people with Opioid Treated Chronic pain. Rehabilitation Dr Harbinder Sandhu
KOPS Investigating why total Knee Arthroplasty (TKA) is a treatment that has a proven benefit; however a proportion of people, possibly as high as one in six, have less satisfactory outcomes after surgery. Trauma and orthopaedics Prof Damian Griffin
MetroLink opens in a new window

Meniscal tear outcome study (METRO). The purpose of this study is find out what is the current management of young patients (patients under 55) with meniscal tears in the population and what happens to these patients.

Surgery, Trauma & Orthopaedics

Associate Clinical Prof Andrew Metcalfe

OPERA Investigating effectiveness and cost-effectiveness of a whole home physical activity intervention to reduce depression in older people in residential and nursing homes. (Published Protocol) Frailty Prof Martin Underwood
PET-NECK Comparing PET-CT guided watch and wait policy versus planned neck dissection for the management of locally advanced (N2/N3) nodal metastases in patients with head and neck squamous cancer. (Published paper) Cancer Prof Janet Dunn
PARAMEDIC Examining whether a new mechanical chest compression device (called LUCAS-2) improves survival in victims of cardiac arrest. (Published Paper) Emergency and critical care Prof Simon Gates & Gavin perkins
PARAMEDIC 2 This trial looks at whether adrenaline is helpful or harmful in the treatment of a cardiac arrest that occurs outside a hospital. Answering this question will help to improve the treatment of people who have a cardiac arrest. Emergency and critical care Prof Gavin Perkins
PIPSLink opens in a new window A Feasibility Study into Patellla Instability: Physiotherapy or Surgery Surgery, Trauma & Orthopaedics Associate Clinical Prof Andrew Metcalfe
Pre-FIT What is the comparative effectiveness of advice, exercise and a multi-factorial fall prevention (MFFP) programme on peripheral fractures among older people living in the community? Frailty Prof Sallie Lamb
ProsperLink opens in a new window Comparing usual care (written information leaflets) versus a physiotherapist-led exercise programme for women at high risk of developing shoulder problems after breast cancer treatment. Musculoskeletal Dr Julie Bruce
RECOVERY - RSLink opens in a new window RECOVERY - Respiratory Support: Respiratory Strategies in COVID-19; CPAP, High-flow, and standard care (Published Paper) Emergency and Critical Care

Prof Gavin Perkins

Prof Danny McAuley

REGAINLink opens in a new windowLink opens in a new window Rehabilitation Exercise and psycholoGical support After covid-19 InfectioN Rehabilitation

Dr Gordon McGregor

RISE Return to work with Individualised Supported Employment (RISE) Rehabilitation Dr Rob Froud
SAFE-TKR Safety and Feasibility Evaluation of Tourniquets for Total Knee Replacement Trauma and orthopaedics Mr Peter Wall

Investigating two approaches to treatment for Rheumatoid Arthritis (RA) affecting the hands.

(Published Paper)

Rehabilitation Prof Sallie Lamb
START:REACTS Sub-acromial spacer for Tears Affecting Rotator cuff Tendons: a Randomised, Efficient, Adaptive Clinical Trial in Surgery (START:REACTS) Surgery, Trauma & Orthopaedics

Associate Clinic Prof Andrew Metcalfe

SELECT-D Anticoagulation Therapy in SELECTeD Cancer Patients at Risk of Recurrence of Venous Thromboembolism (VTE) Cancer Prof Annie Young
WHiTE Looking at the clinical and cost effectiveness of treatments of fracture of the proximal femur. Trauma and orthopaedics Prof Matthew Costa
WOLLF A trial of standard care wound management versus negative pressure wound therapy in the treatment of adult patients with an open fracture of the lower limb. Trauma and orthopaedics Prof Matthew Costa