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Trials in follow up

patient talking to a medical professional

These trials are closed to recruitment but observations on the effects of the intervention and data collection are ongoing.

Trials in follow up

Trial name About the trial Trial type Chief Investigator
RISE Return to work with Individualised Supported Employment (RISE) Rehabilitation Dr Rob Froud
PARAMEDIC 2 This trial looks at whether adrenaline is helpful or harmful in the treatment of a cardiac arrest that occurs outside a hospital. Answering this question will help to improve the treatment of people who have a cardiac arrest. Emergency and critical care Prof Gavin Perkins
SELECT-D Duration of anticoagulation therapy in SELECT-D patients with advanced cancer at risk of recurrence of venous thromboembolism Cancer Professor Annie Young
SAFE-TKR Safety and Feasibility Evaluation of Tourniquets for Total Knee Replacement Trauma and orthopaedics Mr Peter Wall
ARTemis Determining whether the addition to neo-adjuvant chemotherapy of an anti-angiogenic agent bevacizumab is more effective than standard chemotherapy alone in terms of short-term and long-term outcome in women presenting with HER2-negative early breast cancer. Cancer Prof Helena Earl
Breathe Protocolised trial of invasive and non-invasive weaning off ventilation. Emergency and critical care Professor Gavin Perkins
Persephone Comparing six months Herceptin® treatment with twelve months, in patients with early stage breast cancer. Cancer Prof Helena Earl
FIS Assessing the clinical and cost-effectiveness of facet joint injections compared to best usual non-invasive care in patients with persistent non-specific low back pain. Emergency and critical care Dr Harbinder Sandhu
Pre-FIT What is the comparative effectiveness of advice, exercise and a multi-factorial fall prevention (MFFP) programme on peripheral fractures among older people living in the community? Fraility Professor Sallie Lamb
DAPA To answer the question: Does a programme of exercise and physical activity improve cognition for people with mild to moderate dementia? Frailty Professor Sallie Lamb
COMPRESS-SIM A feasibility study of the use of a mechanical chest compression device for inhospital
cardiac arrest
Emergency and critical care Dr Keith Couper
KOPS Investigating why total Knee Arthroplasty (TKA) is a treatment that has a proven benefit; however a proportion of people, possibly as high as one in six, have less satisfactory outcomes after surgery. Trauma and orthopaedics Professor Damian Griffin
FASHIoN Designed to help decide on the best treatment for hip impingement so that we can care for you and others with hip impingement more effectively in the future. Trauma and orthopaedics Professor Damian Griffin
FixDT Comparing intramedullary nail fixation with locking plate fixation for patients with a distal tibia fracture. Trauma and orthopaedics Professor Matthew Costa
DRAFFT A randomised controlled trial of percutaneous fixation with Kirschner wires versus volar locking-plate fixation in the treatment of adult patients with a dorsally displaced fracture of the distal radius Trauma and orthopaedics

Professor Matthew Costa

TEAMM Assessing the benefit of antibiotic prophylaxis and its effect on healthcare associated infection Cancer

Professor Mark Drayson

WOLLF A trial of standard care wound management versus negative pressure wound therapy in the treatment of adult patients with an open fracture of the lower limb. Trauma and orthopaedics Professor Matthew Costa
WHiTE Looking at the clinical and cost effectiveness of treatments of fracture of the proximal femur. Trauma and orthopaedics Professor Matthew Costa
I-WOTCH Improving the Wellbeing of people with Opioid Treated Chronic pain. Rehabilitation Dr Harbinder Sandhu

A Feasibility Randomised Controlled Trial to compare REgional versus General Anaesthesia in Reducing Delirium in patients with Hip Fractures

Emergency and Critical Care

Dr Joyce Yeung

CHESS Investigating the management of chronic headaches.


Prof Martin Underwood

AIR Main UK study of ankle fracture rehabilitation – multicentre randomised
controlled trial


Dr Rebecca Kearney