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Trials in follow up

patient talking to a medical professional

These trials are closed to recruitment but observations on the effects of the intervention and data collection are ongoing.

Trials in follow up

Trial name About the trial Trial type Chief Investigator
AIR Main UK study of ankle fracture rehabilitation – multicentre randomised
controlled trial

Surgery, Trauma & Orthopaedics

Prof Rebecca Kearney

ARTemis Determining whether the addition to neo-adjuvant chemotherapy of an anti-angiogenic agent bevacizumab is more effective than standard chemotherapy alone in terms of short-term and long-term outcome in women presenting with HER2-negative early breast cancer. Cancer Prof Helena Earl
ATM Comparing Platelet Rich Plasma (PRP) to placebo (imitation) injection in adults with Achilles tendon pain Surgery, Trauma & Orthopaedics Prof Rebecca Kearney
Breathe Protocolised trial of invasive and non-invasive weaning off ventilation. Emergency and critical care Prof Gavin Perkins
CHESS Investigating the management of chronic headaches.


Prof Martin Underwood

COMPRESS-SIM A feasibility study of the use of a mechanical chest compression device for inhospital
cardiac arrest
Emergency and critical care Dr Keith Couper
DAPA To answer the question: Does a programme of exercise and physical activity improve cognition for people with mild to moderate dementia? Frailty Prof Sallie Lamb
DRAFFT A randomised controlled trial of percutaneous fixation with Kirschner wires versus volar locking-plate fixation in the treatment of adult patients with a dorsally displaced fracture of the distal radius Trauma and orthopaedics

Prof Matthew Costa

FASHIoN Designed to help decide on the best treatment for hip impingement so that we can care for you and others with hip impingement more effectively in the future. Trauma and orthopaedics Prof Damian Griffin
FixDT Comparing intramedullary nail fixation with locking plate fixation for patients with a distal tibia fracture. Trauma and orthopaedics Prof Matthew Costa
I-WOTCH Improving the Wellbeing of people with Opioid Treated Chronic pain. Rehabilitation Dr Harbinder Sandhu
KOPS Investigating why total Knee Arthroplasty (TKA) is a treatment that has a proven benefit; however a proportion of people, possibly as high as one in six, have less satisfactory outcomes after surgery. Trauma and orthopaedics Prof Damian Griffin
MAMMO-50 Mammographic surveillance in breast cancer patients aged 50 years or older. Cancer Prof Janet Dunn
PARAMEDIC 2 This trial looks at whether adrenaline is helpful or harmful in the treatment of a cardiac arrest that occurs outside a hospital. Answering this question will help to improve the treatment of people who have a cardiac arrest. Emergency and critical care Prof Gavin Perkins
Persephone Comparing six months Herceptin® treatment with twelve months, in patients with early stage breast cancer. Cancer Prof Helena Earl
Pre-FIT What is the comparative effectiveness of advice, exercise and a multi-factorial fall prevention (MFFP) programme on peripheral fractures among older people living in the community? Frailty Prof Sallie Lamb

A Feasibility Randomised Controlled Trial to compare REgional versus General Anaesthesia in Reducing Delirium in patients with Hip Fractures

Emergency and Critical Care

Dr Joyce Yeung

RISE Return to work with Individualised Supported Employment (RISE) Rehabilitation Dr Rob Froud
SAFE-TKR Safety and Feasibility Evaluation of Tourniquets for Total Knee Replacement Trauma and orthopaedics Mr Peter Wall
SELECT-D Duration of anticoagulation therapy in SELECT-D patients with advanced cancer at risk of recurrence of venous thromboembolism Cancer Prof Annie Young
START:REACTS Sub-acromial spacer for Tears Affecting Rotator cuff Tendons: a Randomised, Efficient, Adaptive Clinical Trial in Surgery (START:REACTS) Surgery, Trauma & Orthopaedics

Associate Clinic Prof Andrew Metcalfe

TEAMM Assessing the benefit of antibiotic prophylaxis and its effect on healthcare associated infection Cancer

Prof Mark Drayson

WHiTE Looking at the clinical and cost effectiveness of treatments of fracture of the proximal femur. Trauma and orthopaedics Prof Matthew Costa
WOLLF A trial of standard care wound management versus negative pressure wound therapy in the treatment of adult patients with an open fracture of the lower limb. Trauma and orthopaedics Prof Matthew Costa