RECOVERY-RS trial finds continuous positive airway pressure (CPAP) reduces need for invasive ventilation in hospitalised COVID-19 patients | NIHR (link)

Recent version control monitoring checks have revealed some discrepancies with the wrong versions of Patient Information Sheets and Consent forms used as sites have found the naming of documents confusing to navigate. We apologise for the confusion caused and to help provide clarity of which version to use please see the following table:

As a reminder, if you are unable to obtain consent from a patient with mental capacity or consultee post randomisation before they are discharged/transferred from hospital, you should attempt to contact the patient/consultee up to 3 times by telephone to seek verbal agreement. If you are unsuccessful in reaching them after 3 attempts you do not need to contact them further as we have permission from our REC for the patient’s data to remain in the trial.

RECOVERY-RS is now the largest global non-invasive respiratory support trial for COVID-19 with 1,106 patients recruited as of this morning. We would like to say a huge thank you to all the staff, patients and families involved for helping us reach this incredible milestone!

The DMC for RECOVERY-RS met at the end of January. They noted the considerable progress that had been made since the last DMC meeting, with over 1000 participants now enrolled, making the trial the world’s largest trial of non-invasive ventilation in acute respiratory failure. After careful consideration of the available data, the committee recommended that recruitment continues. A further review will be considered in 4 weeks time. The committee requested that we prioritise obtaining the outcome data for those enrolled to date. We plan to work with NHS Digital, ICNARC and our recruiting sites to obtain as much information as possible to inform the next review.

The investigator team would like to extend their sincere thanks to the patients, families, clinicians and research teams who have supported the trial to date. We plan to provide a further update following the next interim analysis.

RECOVERY-RS team.

A big thank you to all of our recruitment sites, patients and families for helping us reach the milestone of 900 patients recruited. Recruitment has been phenomenal the last few weeks and your hard work does not go unnoticed. Thank you!

Congratulations to our co-investigator Dr Bronwen Connolly on your promotion to Director of Research at the Intensive Care Society. Bronwen's help and support throughout RECOVERY-RS has been invaluable. Very well deserved.

Bronwen is a Senior Lecturer in Critical Care at Queen's University of Belfast and honorary Consultant Clinical Research Physiotherapist at Guy's and St Thomas' NHS Foundation Trust.