Hello!

Welcome to my e-portfolio page. I am currently a PhD student at the Systems Biology Doctoral Training Centre at the University of Warwick, in collaboration with the Liverpool School of Tropical Medicine. My academic background is in Biological Sciences, specifically cellular biology and disease. I graduated from Magdalen College, Oxford with first class honours. My dissertation was based on despeciation driven by bacteriophage in Campylobacter jejuni and Campylobacter coli due changes in ecological niche and was entitled; 'Genomic Analysis of Campylobacter: The Role of Bacteriophage in Speciation'. I completed the Warwick Systems Biology MSc in 2012 with distinction, with both miniprojects relating to plant disease in Arabidopsis.

My PhD is entitled 'A Systems Approach to Unveiling Biological Pathways Associated with Insecticide Resistance in Malaria Vectors.'

The aim of the study is to complete both theoretical and practical approaches to the extensive microarray library currently available in the group, with a branch concentrating on tissue specific datasets. My first year involved writing a program in R that encompasses both a range of microarray analysis methods and a variety of enrichment analyses; this program was used to analyse both tissue specific datasets and 27 microarray experiments available at LSTM. qPCR was used to confirm expression levels of several candidate genes in the tissue array datasets. A metadata exploration of the 27 arrays was carried out using a variety of clustering techniques to determine whether there was a major underlying reason for groupings. Alongside this approach, a correlation network exploration of these data was used to determine whether there are any putative pathways or co-regulation of specific candidates. In all explatory analyses carried out, transcription factors with a putative involvement in insecticide resistance were the major focus. In addition to these, over 100 candidates were found to be potentially up regulated after exposure to the pyrethroid insecticide, deltamethrin. In total, 14 candidates were taken forward and silenced in vivo using RNAi nanoinjection techniques. The results from these data will drive my final year's research.

2012-Present PhD in Systems biology in collaboration with LSTM.

2011-2012 MSc in Systems Biology, University of Warwick.

2008-2011 BA in Biological Sciences, Magdalen College, Oxford.

Major Modules: The Biology of Animal and Plant Disease, Cellular and Developmental Biology and Quantitative Methods

Minor Modules: Evolution and Systematics and Plant and Microbial Biology.