Research Interests

Our lab is interested in how genetic material is packaged in eukaryotes and the implications this has for biological processes. Within each cell of our body, we have nearly four metres of DNA distributed over 46 chromosomes which is sequestered in a nucleus of only 1000 μm3. Chromatin must, therefore, fulfil two conflicting roles: structure DNA so that genomic instability is minimised, but at the same time remain accessible to factors involved in transcription, replication and repair. In studying these contrary roles, our investigations span two length scales, namely the assembly of individual nucleosomes to form the 10 nm fibre and the mechanics of higher-order chromatin domains. To do this we utilise both in vitro biochemical approaches and advanced live-cell imaging.

Scientific Inspiration

Flemming, Jenner, Crick, Franklin, Brenner, Doudna….. who to choose? There are so many inspirational figures in biology & medicine!

Supervision Style

In three words or phrases: Student-led, open-door, research-active

Provision of Training

Initially led by myself at the bench. Specific equipment training provided by Research Technology Platforms (RPTs). As you progress I also encourage students to be proactive in seeking training/protocols/knowledge from others in the division and University as a whole.

Progression Monitoring and Management

Lab members should take ownership of their projects and be the main driving force behind them. As we are a small lab we are discussing our projects weekly, informally, and once a month in a lab meeting on a rotational basis.

Communication

I have an open-door policy. We have a Slack group, but notifications are turned off at weekends (for me at least!).

PhD Students can expect scheduled meetings with me:

These meetings will be ideally face to face, and I am usually contactable for an instant response on every working day.

Work Pattern

The timing of work in my lab is completely flexible, and (other than attending pre-arranged meetings), I expect students to manage their own time.

Notice Period for Feedback

I need at least 2 week’s notice to provide feedback on written work of up to 5000 words.