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Understanding the emergence of uniquely human numerical skills in the developing brain - an investigation using multimodal neuroimaging
Secondary Supervisor(s): Dr Anna Kowalczyk
University of Registration: University of Birmingham
BBSRC Research Themes: Understanding the Rules of Life (Neuroscience and Behaviour)
Project Outline
Background and Aim
From spiders through fish and birds to great apes and humans, the representation of numerosity is implemented in many different brains throughout the animal kingdom (Nieder, 2024, Nat. Rev. Neuroscience). Basic numerical competences such as discriminating quantity (e.g. being able to tell the difference between 2 vs 3 items regardless of their size or other perceptual properties) have deep evolutionary roots and are independent from language. However, humans are the only species to use symbolic number (i.e. symbols that express cardinality, e.g. “five”), develop number systems (e.g. Arabic numerals) and entire disciplines of knowledge dedicated to the study of number (i.e. mathematics). Moreover, the use of symbolic number is integral to our daily lives to track time, do grocery shopping, pay bills. Where does the ability to use and manipulate symbolic number come from? When and how does it emerge? Is it triggered by language acquisition of formal education? What are its biological bases? Brand new research provides evidence that this uniquely human capacity for symbolic number may emerge already in the first year of life (Gennari et al., 2023, Curr. Biol.; Pomiechowska et al., 2024, PNAS) before infants are able to speak. Critically, its neural bases remain largely unexplored. This project aims to understand how the infant brain develops numerical symbols and learns to combine them.
Objectives
This project sets three objectives: (1) to identify behavioral signatures of numerical symbols and operations in human infants, (2) to identify neural signatures indexing the processing of numerical symbols and operations, (3) to describe the neural networks involved in numerical symbols and operations in the infant brain.
Methods
This project will involve behavioral and neuroimaging experiments with human infants, and adults for benchmarking. Two distinct but complementary neuroimaging methods will be used: electroencephalography (EEG) and magnetoencephalography (MEG) based on novel type of sensors Optically Pumped Magnetometers (OPMs). OPM-MEG is an emerging technique that offers a step-change opportunity for electrophysiological brain imaging in infancy. In contrast to conventional magnetoencephalography (MEG), OPM-MEG does not involve cryogenics so the sensors can be freely placed around the head and closer to the scalp, allowing for both stronger signal and infant-friendly headgear. This is particularly advantageous for measuring brain function in the infant brain.
Students will collect OPM-MEG and EEG data, and will do cortical source reconstruction using MRI data. Students will use multivariate pattern analysis, a novel analysis method inspired by machine learning, and representational similarity analysis. This experience will not only deepen their understanding of neural data but also equip them with valuable skills in advanced data analysis techniques. Students will work across Birmingham Babylab and Quantum Neuroscience labs at the Centre of Human Brain Health and Centre for Developmental Science.
Interested students are strongly encouraged to contact the lead supervisor (Dr Barbara Pomiechowska, b.pomiechowska@bham.ac.uk) for informal discussion before submitting an application.
Key References
Gennari, G., Dehaene, S., Valera, C., & Dehaene-Lambertz, G. (2023). Spontaneous supra-modal encoding of number in the infant brain. Current Biology, 33(10), 1906-1915.
Nieder, A. (2016). The neuronal code for number. Nature Reviews Neuroscience, 17(6), 366-382.
Pomiechowska, B., Bródy, G., Téglás, E., & Kovács, Á. M. (2024). Early-emerging combinatorial thought: Human infants flexibly combine kind and quantity concepts. Proceedings of the National Academy of Sciences, 121(29), e2315149121.