Name	Description	Keywords
PDF document	10 Hornsey, M. " Development and validation of loop-mediated isothermal amplification (LAMP) assays for the detection of Acinetobacter spp., Corynebacterium spp., Enterobacter spp. and Streptococcus canis (...) companion animals"	Loop-Mediated Isothermal Amplification (LAMP)-based assays have been described for important companion animal pathogens. Companion animals, especially dogs and cats, are known to carry clinically significant, antibiotic-resistant bacteria with zoonotic potential. We describe the development of four novel LAMP-based assays designed to detect commonly encountered, veterinary bacterial pathogens.	diagnostics, antibiotic resistance detection, zoonotic, isothermal
PDF document	11 Watkins, J. "Community-based antibiotic access and use in rural South Africa"	The ABACUS study’s aim is to compare sociocultural determinants of appropriate access and use of antibiotics between six different low- and middle-income countries (LMICs) (Asia: Bangladesh, Vietnam, Thailand; Africa: Mozambique, Ghana, South Africa) to provide a uniform framework for appraising current antibiotic use patterns, which may subsequently be used in other LMIC communities. We aim to: i) Assess community reported supply and use of antibiotics, verified by metrics. ii) Identify contextualized factors and behaviours that may serve as targets for development of tailored interventions. iii) Distinguish country specific provision and needs.	behaviour, modelling, prescribing, compliance, public health, community
PDF document	12 Borsetto, C. "Bacteroidetes: Potential for Novel Natural Products"	This study aims firstly to identify potential drivers of secondary metabolites diversity in different soils, followed by characterising identified biosynthetic gene clusters for the discovery of novel antimicrobial natural products.	natural products, novel antibiotics, antimicrobials
PDF document	13 Chen, J. "Novel Organometallic Complexes with Potent Selective Antimicrobial Activity"	Novel antimicrobials with new mechanisms of action are urgently needed. We have synthesized a new class of organometallic antimicrobial complexes and characterized them by NMR, ESI-MS and elemental analysis (CHN), and X-ray crystallography.	synthetic chemistry, antimicrobials, novel antibiotics
PDF document	14 Gibson, M. "Non-Traditional Biomaterial Solutions to Infection. Detect, Neutralize and Kill"	Our research is focused at the interfaces of Carbohydrate and Polymer Chemistries with the Life Sciences. We study, and create, innovative solutions for global healthcare challenges. This includes the storage of cells and tissues, biosensors for low resource environments, bionanotechnology, infectious disease and fundemental studies on macromolecules.	novel antibiotics, antimicrobials, diagnostics, carbohydrates
PDF document	15 Micelli, C. "Towards the Discovery of New Antimicrobials: the Bifunctional Penicillin Binding Proteins"	This project, focuses on the structural and enzymatic characterization of Penicillin Binding Protein (PBP) 1a from the nosocomial pathogens Pseudomonas aeruginosa and Acinetobacter baumannii. PBP1a is an important enzyme of the peptidoglycan biosynthetic pathway and a well-validated antibacterial target.	biochemistry, antibiotic resistance, structural biology
PDF document	16 Maskew, K. "Dissecting the molecular mechanisms of MRSA; a threat to food security."	Despite the importance of MecA in both clinical and veterinary β-lactam MRSA infections, the enzymology of this crucial target has remained inaccessible. This project aims to characterise the biochemistry underpinning staphylococcal β-lactam resistance and its impact upon antibiotic resistance in the context of food security. If successful, it will allow for the first time, characterization of the enzyme activity of MecA.	biochemistry, antibiotic resistance, virulence
PDF document	17 Moat, J. "Warwick Antimicrobial Discovery Facility"	Funded by INTEGRATE AMR, a new antimicrobial testing facility located within the School of Life Sciences is being developed to support antimicrobial resistance (AMR) research and antibiotic discovery by members of the AMR community across the University, including the physical, life and medical sciences. The facility will allow the establishment and validation of current and novel approaches to antimicrobial testing in support of our diverse research activities.	novel antibiotics, antimicrobials, screening, target identification, target validation, drug discovery
PDF document	18 Salimraj, R. and Cain, R. "Multitargeting of tRNA synthetases: A paradigm shift in combating antimicrobial resistance"	The objective of this project is to obtain a structural data set of selected bacterial enzymes in amino-acyl site mimetics. We have made significant progress in this respect and have been able to design a probe compound set to investigate selectivity between the human and bacterial forms of the seryl aminoacyl tRNA synthetases and to further explore the potential of the probe for multi-targeting against other aminoacyl tRNA synthetases.	novel antibiotics, structural biology, antimicrobials, biochemistry, drug discovery, target validation
PDF document	19 Fu, T. "Microscopic and macroscopic characterization of diet-induced adaptive antimicrobials resistance in gut microbiota swarmers"	The aim of this project is to characterize subpopulation to single-cell resolution of swarming cell response to antibiotics. Specifically, I aim to investigate the intriguing link of choline metabolism, enhanced swarming and subsequently enhanced antimicrobial resistance using P. mirabilis as the model, and test the hypothesis that choline enhances swarming speed and thus elevated resistance to antibiotics.	cell biology, biofilms, virulence, antibiotic resistance
PDF document	20 Kuroki, A. "Structure-Activity Relationship of Synthetic Antimicrobial Peptide Mimics (SAMPs) obtained by RAFT"	As more research focuses on the role of antimicrobial peptides (AMPs) as a way to tackle the development of resistance against antibiotics, synthetic versions of AMPs have recently attracted increasing interest. Polymeric materials have predominantly appeared as the ideal candidates because their properties can be tuned easily and can be much cheaper to produce on industrial scale than peptides.	synthetic chemistry, polymers, peptides, novel antibiotics, antimicrobials
PDF document	21 Kulkarni, V. "Improved Predictive Models using Omics Data"	We propose new results on constraint-based resource allocation (COBRA) framework to integrate transcriptomic data with public domain metabolic network models to obtain improved predictions of the metabolic flux distribution in well-studied micro-organisms.	modelling, target identification, virulence
PDF document	22 Covington, J. "Diagnosis of Respiratory Infections through Human Breath"	The development of a high throughput, non invasive breath test that can determine whether a patient has a bacterial or viral infection would allow patients to be treated in the appropriate care path quickly whilst reducing use of antibiotics in a clinical setting. The work in the Biological Sensors Lab in conjunction with collaborators have focused on answering this questions, with particular focus on tuberculosis, in a clinical setting.	devices, diagnostics, non-invasive, clinical, patient
PDF document	23 Hartlieb, M. "Responsive Polymer Conjugates of Cyclic Peptide Nanotubes as Smart Antibiotics"	The aim of our work is to design CPNT, which are reversibly connected to a polymeric shell in order to achieve a stimuli-responsive antimicrobial activity upon cleavage.	novel antibiotics, polymers, drug delivery, synthetic chemistry
PDF document	24 Sirec, T. "Electrophysiological Dynamics During Sporulation in B. subtilis"	Calcium is the most abundant carbon in mature spores and is essential for production of viable and resistant spores. However, the dynamics and role of calcium during the sporulation process are poorly understood. We examined dynamics of calcium in sporangia and the effect of alterations of calcium dynamics on the sporulation process at single-cell level in B. subtilis	cell biology, virulence, target identification
PDF document	25 Fullam, E. "TB Research at Warwick"	There is an urgent need for the identification of novel targets and pathways within M. tuberculosis to develop new chemotherapeutic agents and diagnostic tools. Can carbohydrate processing pathways be utilised for new anti-tubercular agents/diagnostics?	tuberculosis, novel antibiotics, antimicrobials, diagnostics, carbohydrates
PDF document	30 Bees, M. Modelling and visualisation of nascent biofilms and the action of anti-biofilm treatments	Lactam analogues developed by Unilever disrupt biofilm formation and could feature in a range of commercial products, including domestic cleaning products. The active components can jam quorum sensing, acting as antagonists of signal molecule receptors on Gram negative bacteria. However, the complete action of the lactam analogues is not fully understood. Unilever requires a physical understanding of the biofilm inhibitors for regulatory purposes in order to take them to market. Using mechanistic modelling (with analytical and numerical analysis) and visualisation techniques (particularly digital holographic microscopy), we have investigated the three-dimensional fluid dynamics of nascent biofilms and the action of anti-biofilm treatments. These approaches aim to identify how lactam analogues limit biofilm growth, and inform the design of next generation anti-biofilm technologies.	biofilms, quorum sensing. novel antimicrobials
PDF document	31 Viadynamics: Antimicrobial Resistance – A System Solution Approach	Viadynamics has developed an approach that cuts through complexity to address big systemic challenges. This is being honed in several fields, from Off Shore Wind Energy to Corrosion and AMR. Via’s System Solution SpaceTM provides a simple yet holistic way to look at the total landscape of a challenge and its potential solutions routes. The map enables more active portfolio management; kick-starting work in under-explored areas, as well as encouraging collaboration in ‘hotspots’ where there is significant, but as yet not ‘joined up’ activity. It also validates and helps build capabilities that can be leveraged across multiple solution routes. The AMR System Solution SpaceTM is designed to help funders better deploy their resources in order to activate multi-disciplinary academic and industry communities to create new and better interventions across the spectrum of opportunities - with the end goal of mitigating the rise of AMR.	portfolio management, collaboration, systems
PDF document	7 Newcombe, J. and Hingley-Wilson, S. "SPIDERS: Surface Printing to Investigate Drug Effects on Real Surfaces"	Bacterial resistance to antimicrobials is exacerbated by their propensity to form biofilms on inorganic and organic surfaces. Bacterial resistance and tolerance of antimicrobials has been studied in ‘flow cells’: compartmentalised devices in which bacteria are suspended and grown and to which antimicrobials can be introduced in a controlled manner. We have used 3D additive manufacture to print flow cells directly onto the biofilm of interest or on a natural surface, which we can then grow biofilms on.	biofilms, antimicrobials, flow cells, surfaces
PDF document	8 Newcombe, J. and Roth, P.J. "Antifouling Coatings to Prevent Biofilm Formation"	The prevention of biofilm formation remains an important challenge in the field of antimicrobial resistance (AMR). This project is aimed at using multi-layers of reactive polymers to coat and post-functionalise a variety of different surfaces in order to prevent the formation of a biofilm.	biofilms, polymers, coatings, surfaces, antifouling