Theme 2 research addresses the challenges of building tailor-made and fully controllable biosynthetic pathways.

WISB researchers are developing novel SB tools for engineering biosynthetic pathways to generate structurally complex bioactives in microorganisms such as Streptomyces sp. and Saccharomyces cerevisiae. Rate control engineering, combined with high-resolution systems analysis, enables us to create highly efficient synthetic pathways.

Publications:

Peter J. Rutledge, Gregory L. Challis, Discovery of microbial natural products by activation of silent biosynthetic gene clusters, Nature Reviews Microbiology 13, 509–523 (2015) doi:10.1038/nrmicro3496