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Gibson Group: Akalabya Bissoyi


      Akalabya Bissoyi was born in Bhubaneshwar, Odisha, India, and he completed his Bachelor’s degree in pharmacy from Utkal University. Master’s degree in Biotechnology from the National Institute of Technology, Rourkela, India. His thesis focuses on the synthesis of H3 inverse agonists with AchE inhibitor properties and QSAR studies of H3 receptor antagonists.

      Subsequently, Akalabya Bissoyi did his Ph. D under the guidance of Dr. Krishna Pramanik, Dept. of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, Odisha, India, and was awarded the Ph.D. degree in 2015 with a thesis on “Cryopreservation of mesenchymal stem cell and tissue-engineered constructs using non-toxic cryoprotective agents

      As a former postdoctoral student at the Hebrew University of Jerusalem in Israel, his research focuses on the role that antifreeze and ice nucleating proteins play in tissue cryopreservation. In addition, he has been developing a new cryopreservation device for cell and organ-on-chip devices.

      Dr. Akalabya Bissoyi's research interests include cryobiology, stem cell engineering, and ice-binding proteins.

      Selected Peer-Reviewed Publications

      1. Bissoyi, A., & Braslavsky, I. (2021). Adherent cell thawing by infrared radiation. Cryobiology.

      2. Tripathi SS, Kumar R, Bissoyi A, Rizvi SI, Baicalein maintains redox balance in experimental hyperlipidemic rats, Archives of Physiology and Biochemistry, 1-9.

      3. Bissoyi, A.; Reicher, N.; Chasnitsky, M.; Arad, S.; Koop, T.; Rudich, Y.; Braslavsky, I. Ice Nucleation Properties of Ice-binding Proteins from Snow Fleas. Biomolecules 2019, 9, 532.

      4. Singh, A.K., Singh, S., Tripathi, V.K., Bissoyi, A., Garg, G. and Rizvi, S.I., 2019. Rapamycin

      Confers Neuroprotection Against Aging-Induced Oxidative Stress, Mitochondrial Dysfunction, and Neurodegeneration in Old Rats Through Activation of Autophagy. Rejuvenation research, 22(1), pp.60-70.

      5. Singh, S., Garg, G., Singh, A.K., Bissoyi, A. and Rizvi, S.I., 2019. Fisetin, a potential caloric restriction mimetic, attenuates senescence biomarkers in rat erythrocytes. Biochemistry and Cell Biology.

      6. Agrawal, P., Pramanik, K. and Bissoyi, A., 2018. Novel Blowspun Nanobioactive Glass Doped Polycaprolactone/Silk Fibroin Composite Nanofibrous Scaffold with Enhanced Osteogenic Property for Bone Tissue Engineering. Fibers and Polymers, 19(12), pp.2465-2477.

      7. Gupta, S., Bissoyi, A. & Bit, A. A Review on 3D Printable Techniques for Tissue Engineering, BioNanoSci. (2018).

      8. Maji, K., Dasgupta, S., Pramanik, K., & Bissoyi, A. (2018). Preparation and characterization of gelatin-chitosan-nanoβ-TCP based scaffold for orthopaedic application. Materials Science and Engineering: C.

      9. Agrawal, Krishna Pramanik, Varshini Vishwanath, Amit Biswas, Bissoyi, A, Pradeep Kumar Patra. Enhanced chondrogenesis of mesenchymal stem cells over silk fibroin/chitosan-chondroitin sulfate three dimensional scaffold in dynamic culture.condition. Journal of Biomedical Materials Research Part B: Applied Biomaterials (2018) DOI: 10.1002/jbm.b.34074

      10. Singh, A.K., Jha, A., Bit, A., Kiassov, A.P., Rizvanov, A.A., Ojha, A., Bhoi, P., Patra, P.K., Kumar, A. and Bissoyi, A., 2017. Selaginella bryopteris aqueous extract improves stability and function of cryopreserved human mesenchymal stem cells. Oxidative medicine and cellular longevity, 2017.

      11. Bissoyi, A. Abhishek Kumar Singh, Subrat Kumar Pattanayak, Arindam Bit, Sudip Kumar Sinha, Ashish Patel, Vishal Jain, and Pradeep Kumar Patra. "Understanding molecular mechanism of improved proliferation and osteogenic potential of human mesenchymal stem cells grown on polyelectrolyte complex derived from non-mulberry silk fibroin and chitosan." Biomedical Materials (2017).

      12. Arindam Bit, Awanish Kumar, Abhishek Kumar Singh, Albert A. Rizvanov, Andrey P. Kiassov, Pradeep Kumar Patra, Bissoyi, A*, Crosstalk between Substrates and Rho-associated Kinase inhibitors in Cryopreservation of Tissue Engineered Constructs, Stem Cells International

      13. Singh, Abhishek Kumar, Bissoyi, A*, Mahendra Pratap Kashyap, Pradeep Kumar Patra, and Syed Ibrahim Rizvi. "Autophagy Activation Alleviates Amyloid-β-Induced Oxidative Stress, Apoptosis and Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells." Neurotoxicity Research (2017): 1-11.

      14. Behera SS, Das U, Kumar A, Bissoyi A*, Singh AK (2017) Chitosan/TiO2 composite membrane improves proliferation and survival of L929 fibroblast cells: Application in wound dressing and skin regeneration. International Journal of Biological Macromolecules, In Press, DOI: 10.1016/j.ijbiomac.2017.02.017

      15. Bissoyi A*, Bit A, Singh BK, Singh AK, Patra PK (2016) Enhanced cryopreservation of MSCs in the microfluidic bioreactor by regulated shear flow. Scientific Reports, 6, 35416. DOI: 10.1038/srep35416

      16. Tarai, S., Bit, A., dos Reis, H.J., Palotás, A., Rizvanov, A., and Bissoyi, A. (2016) Stratifying Heterogeneous Dimension of Neurodegenerative Diseases: Intervention for Stipulating Epigenetic Factors to Combat Oxidative Stress in Human Brain. BioNanoScience, 6(4), pp.411-422.

      17. Bissoyi, A., Kumar, A., Rizvanov, A.A., Nesmelov, A., Gusev, O., Patra, P.K. and Bit, A.(2016) Recent Advances and Future Direction in Lyophilisation and Desiccation of Mesenchymal Stem Cells. Stem Cells International.

      18. Maji, K., Dasgupta, S., Pramanik, K, & Bissoyi, A. (2015) Preparation and Evaluation of

      Gelatin- Chitosan NanoBioglass 3D Porous Scaffold for Bone Tissue Engineering, International Journal of Biomaterials.

      19. Agarwal, T., Asthana, S., & Bissoyi, A*. (2015). Molecular modeling and docking study to elucidate novel chikungunya virus nsP2 protease inhibitors. Indian Journal of Pharmaceutical Sciences, 77(4), 453.

      20. Mukhopadhyay, S., Das, D. N., Panda, P. K., Sinha, N., Naik, P. P., Bissoyi, A., & Bhutia, S. K. (2015). Autophagy protein Ulk1 promotes mitochondrial apoptosis through reactive oxygen species. Free Radical Biology and Medicine.

      21. Maji, K., Dasgupta, S., Kundu, B., & Bissoyi, A. (2015). Development of gelatin-chitosan-hydroxyapatite based bioactive bone scaffold with controlled pore size and mechanical strength. Journal of Biomaterials Science, Polymer Edition, 1-20.

      22. Mukhopadhyay, S., Panda, P. K., Behera, B., Das, C. K., Hassan, M. K., Das, D. N., Bissoyi A., Pramanik, K., Bhutia, S. K.(2014) Antitumor effect of soybean lectin mediated through reactive oxygen species-dependent pathway. Life sciences, 111(1), 27-35.

      23. Panda, N.; Bissoyi, A.; Biswas, A.; Pramanik, K.,(2014) “Development of novel electrospun nanofibrous scaffold from P. ricini and A. mylitta silk fibroin blend with improved surface and biological properties. Materials Science and Engineering: C, 48, 521-532.

      24. Panda, N.; Bissoyi, A.; Biswas, A.; Pramanik, K.,(2014) “Directing osteogenesis of stem cells with hydroxyapatite precipitated electrospun eri–tasar silk fibroin nanofibrous scaffold. Journal of Biomaterials Science, Polymer Edition, 25(13), 1440-1457.

      25. Bissoyi, A., & Pramanik, K. (2014). Role of the apoptosis pathway in cryopreservation-

      induced cell death in mesenchymal stem cells derived from umbilical cord blood. Biopreservation and biobanking, 12(4), 246-254.

      26. Bissoyi, A., Pramanik, K., Panda, N. N., & Sarangi, S. K. (2014). Cryopreservation of hMSCs seeded silk nanofibers based tissue-engineered constructs. Cryobiology, 68(3), 332-342. 25. Bissoyi, A., Nayak, B., Pramanik, K., & Sarangi, S. K. (2014). Targeting Cryopreservation-Induced Cell Death: A Review. Biopreservation and biobanking, 12(1), 23-34.

      27. Bissoyi, A., & Pramanik, K. (2013). Effects of Non-Toxic Cryoprotective Agents on the Viability of Cord Blood-Derived MNCs. Cryoletters, 34(5), 453-465.

      28. Mukhopadhyay, S., Panda, P. K., Behera, B., Das, C. K., Hassan, M. K., Das, D. N., Bissoyi A., Bhutia, S. K. (2014). In vitro and in vivo antitumor effects of Peanut agglutinin through induction of apoptotic and autophagic cell death. Food and Chemical Toxicology, 64, 369-377.

      Book Chapter

      1. *Akalabya Bissoyi, Subrat Kumar Pattanayak Arindam Bit Ashish Patel, Abhishek, Alpha-virus Non-structural Proteases and Their Inhibitors, Viral Proteases and Their Inhibitors, 1st Edition, Elsevier, ISBN: 9780128097120

      2. Apramita Chand, Pragin Chettiyankandy1, Subrat Kumar Pattanayak2, Mahasweta Moharana3, Akalabya Bissoyi4, Abhishek Kumar Singh5, Snehasis Chowdhuri1 Computational methods for developing novel anti-aging interventions, Molecular basis and emerging strategies for anti-aging interventions, 1st edition, Springer.


      1. Cryobiology, Virtual Meeting 2020.

      2. Fifteenth Annual Meeting of SFRR-India 2017 (SFRR-INDIA-17) at Bhabha Atomic Research Centre, Trombay, Mumbai, India

      3. Second International Conference on Tissue Engineering and Regenerative Medicine (ICTERM-13), NIT Rourkela, India Nov-2013.

      4. Termis, Vienna, Austria, 2012.

      5. Cellular & Molecular Biophysics at CCMB Hyderabad, India on Jan 20, 2009.


      1.Winner of Nano art competition(2019) at Nano Conference organized by Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem.

      2. PBC fellowship from the Government of Israel for the year 2018-2020.

      3. Research Associateship: DBT, Government of India, Department of Biotechnology and Medical Engineering, National Institute of Technology, Odisha India (June, 2009- December 2009)

      4. Senior Research Fellowship (SRF, Project), Department of Biotechnology, Government of India, National Institute of Technology, Odisha India (January 2010- December 2014)

      5. Awarded 1st prize for oral presentation in ICTERM-2011 (N.I.T Rourkela, 2011)

      6. Graduate Aptitude Test for Engineering (GATE) Qualified (Rank 530), Percentile-99, Year-2007 conducted by IIT Kanpur.

      Research Grants/Projects Received as PI from National/International funding agencies

      Mechanotransduction behaviour of Osteoblast in Scaffold Construct before and after cryopreservation - Department of Science and Technology, India 47,000 USD Completed 2016 to 2019




      Web of Science Research ID: AAA-9848-2020