Gibson Group: Collette Guy
Collette was born in Grantham, Lincolnshire in 1987, where she completed her GCSEs (2001-2003) and A-Levels (2003-2005) at Kesteven and Grantham Girls School. Collette studied for her undergraduate degree in Chemistry with Medicinal Chemsitry with Industrial Experience at The University of Warwick, graduating in 2009 with a 1st class honours degree.
In her third year of her undergraduate Collette undertook a industrial placement year at AstraZeneca, Charnwood, in the Medicinal Chemistry Deparment working in the respiratory and inflammation therapeutic areas.
Collette's final year MChem project was in the group of Dr. Andrew Clark in the area of copper mediated radical cyclisations.
Collette then remained in the Clark group to undertake her PhD "New approaches to nitrogen heterocycles via radical cyclisations." The project looked at the cyclisation of enamides to form lactams, and the possibilty of exploiting the chiratiy of the enamides, which arises through atropisomerism, as a means of chirality transfer into the product. The copper mediated radical cyclisation of anilides to give oxindoles was also investigated.
In November 2015 Collette began a Post Doc joint between the Gibson group (Chemistry) and the Fullam group (Life Sciences) focussing on the design and synthesis of new compounds to be screened against mycobacteria as potenial new antibiotic reagents.
Osmium-arene complexes with high potency towards Mycobacterium tuberculosis J. P. C. Coverdale, C. S. Guy, H. E. Bridgewater, R. J. Needham, E. Fullam, P. J. Sadler, Submitted 2020
Unravelling the specificity and structural basis of trehalose recognition buy the mycobacterial LpqY-SugABC transporter C. M. Furze, I. Delso, E. Casal, C. S. Guy, C. Seddon, H. L. Parker, A. Radhakrishnan, R. Pacheco-Gomez, J. Angulo, A. D. Cameron, E. Fullam Submitted 2020
The SARS-COV-2 Spike Protein Binds Sialic Acids and Enables Rapid Detection in a Lateral Flow Point of Care Diagnostic Device A. N. Baker, S-J. Richards, C. S. Guy, T. R. Congdon, M. Hasan, A. J. Zwetsloot, A. Gallo, J. R. Lewandowski, P. J. Stansfeld, A. Straube, M. Walker, S. Chessa, G. Pergolizzi, S. Dedola, R. A. Field, M. I. Gibson, ACS Cent. Sci. 2020
Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria H. L. Parker, R. M. F. Tomas, C. M. Furze, C. S. Guy, E. Fullam, Org. Biomol. Chem., 2020, 18, 3607-3612.
Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis C. S. Guy, K. Murray, M. I Gibson, E. Fullam, Org. Biomol. Chem., 2019, 17, 9524-9528.
Structural basis of glycerophosphodiester recognition by the Mycobacterium tuberculosis substrate-binding protein UgpB , , C. , , , ,
Targeting extracellular glycans: tuning multimeric boronic acids for pathogen-selective killing of Mycobacterium tuberculosis , , E. Fullam, Chem. Sci., 2019, 10, 5935-5942
Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA) M. S. Ahangar, C. M. Furze, C. S. Guy, C. Cooper, K. S. Maskew, B. Graham, A. D. Cameron and E. Fullam, J. Biol. Chem. 2018, 293, 9770-9783
Identification of the anti-mycobacterial functional properties of piperidinol derivatives C. S. Guy, E. Tichauer, G. L. Kay, D. J. Phillips, T. L. Bailey, J. Harrison, C. M. Furze, A. D. Millard, M. I. Gibson, M. J. Pallen, E. Fullam, Br. J. Pharmacol. 2017, 14, 2183-2193
Evaluation of the Antimicrobial Activity of Cationic Polymers Against Mycobacteria: Towards Anti-Tubercular Macromolecules D. Phillips, J. Harrison, S-J. Richards, D. E. Mitchell, E. Tichauer, A. T. M. Hubbard, C. S. Guy, I. Hands-Portman, E. Fullam, M. I. Gibson, Biomacromolecules, 2017, 18, 1592–1599
Axially Chiral Enamides: Substituent Effects, Rotation Barriers and Implications for their Cyclisation Reactions. A. J. Clark, D. P. Curran, D. A. Fox, F. Ghelfi, C. S. Guy, B. Hay, J. M. Phillips, F. Roncaglia, P. B. Sellars, P. Wilson, H. Zhang, J. Org. Chem. 2016, 81, 5547–5565
Reduction of Ketones to Alkenes. A. J. Clark and C. S. Guy. ’Comprehensive Organic Synthesis II', 2014, Volume 8, Elsevier, 1143-1163.
1,4-Aryl migration under copper(I) atom transfer conditions. A. J. Clark, S. R. Coles, A. Collis, T. Debure, C. Guy, N.P Murphy, P. Wilson, Tetrahedron Lett., 2009, 50, 5609.
Copper-mediated N-arylation of quinazolinediones. C. Guy, T. C. Jones, Synlett, 2009, 14, 2253.
Full citation information from Google Scholar here.
RSC Chemical Biology and Bio-Organic Group Forum, Leicester, Jan 2020 - Poster presentation 'Targeting extracellular glycine: Tuning multimeric moronic acids for pathogenic-elective killing of Mycobacterium tuberculosis'
Acid Fast Club Winter meeting, London, Jan 2019 - Oral presentation 'Chemical tools to target Mycobacterium tuberculosis'
RSC Chemical Biology Symposium, London, 21st May 2018 - Poster presentation 'Development of tools to understand nutrient processing in mycobacteria'
Grants and Bursaries
Collette was awarded the Warwick Postgraduate Research Scholarship to fund her PhD.
The University of Warwick
MChem (Chemistry with Medicinal Chemistry with Industrial Experience), 1st Class Honours, 2005-2009
PhD in Chemistry (New approaches to nitrogen heterocycles via radical cyclisations), 2009-2014