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Gibson Group: Collette Guy

Biography

Collette was born in Grantham, Lincolnshire in 1987, where she completed her GCSEs (2001-2003) and A-Levels (2003-2005) at Kesteven and Grantham Girls School. Collette studied for her undergraduate degree in Chemistry with Medicinal Chemsitry with Industrial Experience at The University of Warwick, graduating in 2009 with a 1st class honours degree.

In her third year of her undergraduate Collette undertook a industrial placement year at AstraZeneca, Charnwood, in the Medicinal Chemistry Deparment working in the respiratory and inflammation therapeutic areas.

Collette's final year MChem project was in the group of Dr. Andrew Clark in the area of copper mediated radical cyclisations.

Collette then remained in the Clark group to undertake her PhD "New approaches to nitrogen heterocycles via radical cyclisations." The project looked at the cyclisation of enamides to form lactams, and the possibilty of exploiting the chiratiy of the enamides, which arises through atropisomerism, as a means of chirality transfer into the product. The copper mediated radical cyclisation of anilides to give oxindoles was also investigated.

In November 2015 Collette began a Post Doc joint between the Gibson group (Chemistry) and the Fullam group (Life Sciences) focussing on the design and synthesis of new compounds to be screened against mycobacteria as potenial new antibiotic reagents.


Publications

Identification of the anti-mycobacterial functional properties of piperidinol derivatives C. S. Guy, E. Tichauer, G. L. Kay, D. J. Phillips, T. L. Bailey, J. Harrison, C. M. Furze, A. D. Millard, M. I. Gibson, M. J. Pallen, E. Fullam, Br. J. Pharmacol. 2017, 14, 2183-2193

Evaluation of the Antimicrobial Activity of Cationic Polymers Against Mycobacteria: Towards Anti-Tubercular Macromolecules D. Phillips, J. Harrison, S-J. Richards, D. E. Mitchell, E. Tichauer, A. T. M. Hubbard, C. S. Guy, I. Hands-Portman, E. Fullam, M. I. Gibson, Biomacromolecules, 2017, 18, 1592–1599

Axially Chiral Enamides: Substituent Effects, Rotation Barriers and Implications for their Cyclisation Reactions. A. J. Clark, D. P. Curran, D. A. Fox, F. Ghelfi, C. S. Guy, B. Hay, J. M. Phillips, F. Roncaglia, P. B. Sellars, P. Wilson, H. Zhang, J. Org. Chem. 2016, 81, 5547–5565


Reduction of Ketones to Alkenes. A. J. Clark and C. S. Guy. ’Comprehensive Organic Synthesis II', 2014, Volume 8, Elsevier, 1143-1163.

1,4-Aryl migration under copper(I) atom transfer conditions. A. J. Clark, S. R. Coles, A. Collis, T. Debure, C. Guy, N.P Murphy, P. Wilson, Tetrahedron Lett., 2009, 50, 5609.

Copper-mediated N-arylation of quinazolinediones. C. Guy, T. C. Jones, Synlett, 2009, 14, 2253.

Full citation information from Google Scholar here.

Orcid ID

orcid.org/0000-0002-5153-0613

Grants and Bursaries

Collette was awarded the Warwick Postgraduate Research Scholarship to fund her PhD.



PHOTO

Collette

Education

The University of Warwick

MChem (Chemistry with Medicinal Chemistry with Industrial Experience), 1st Class Honours, 2005-2009

PhD in Chemistry (New approaches to nitrogen heterocycles via radical cyclisations), 2009-2014