Biography

Muhammad was born in Rawalpindi, Pakistan in 1984. He completed his schooling in many different countries, specifically, he did GCE 'O' Levels in Singapore (1998-2000) and GCE 'A' Levels in Pakistan (2001-2003). He was subsequently awarded the Reach Oxford Scholarship to read Mathematics at Magdalen College, Oxford (2004-2007).

In his final year he began to take a keen interest in Mathematical Biology and hence decided to enrol in the MSc + PhD programme in Mathematical Biology and Biophysical Chemistry at the Molecular Organisation and Assembly in Cells (MOAC) DTC. He then joined the Gibson group and set up the new lab at the Warwick Medical School.

Research Interests

Investigating the structure-activity relationship of ice-binding proteins to:

i) understand how these proteins function in their native environments.

ii) develop non-natural analogues and conjugates.

iii) explore their use as cryoprotective agents in laboratory and industrial contexts.

Publications

[12] Fayter, AER., Hasan, M., Congdon,TR., Kontopoulou, I., Gibson, M.I., European Polymer Journal, Ice Recrystallisation Inhibiting Polymers Prevent Irreversible Protein Aggregation During Solvent-Free Cryopreservation as Additives and as Covalent Polymer-Protein Conjugates, 2020, DOI: 10.1016/j.eurpolymj.2020.110036

[11] Baker, A.N., Richards, S.J., Guy, C.S., Congdon, T.R., Hasan, M., Zwetsloot, A.J., Gallo, A., Lewandowski, J.R, Stansfeld, P.J., Anne Straube, A., Walker, M., Chessa, S., Pergolizzi, G., Dedola, S., Field, R.A. and Gibson, M.I., ACS Central Science, The SARS-COV-2 spike protein binds sialic acids, and enables rapid detection in a lateral flow point of care diagnostic device, 2020., DOI: 10.1021/acscentsci.0c00855

[10] Tomas, MFR., Bailey, T.L., Hasan, M., Gibson, MI., Biomacromolecules, Extracellular Antifreeze Protein Significantly Enhance the Cryopreservation of Cell Monolayers, 2019, DOI:10.1021/acs.biomac.9b00951

[9] Ishibe, T., Congdon, TR., Stubbs C., Hasan, M., Sosso, G., Gibson, MI., ACS Macro Letters, Enhancement of Macromolecular Ice Recrystallisation Inhibition Activity by Exploiting Depletion Forces, 2019. DOI:10.1021/acsmacrolett.9b00386

[8] Hasan, M., Patel, D., Ellis, N., Brown, SP., Lewandowski, JR., Dixon, AM., J. Membr. Biol., Modulation of Transmembrane Domain Interactions in Neu Receptor Tyrosine Kinase by Membrane Fluidity and Cholesterol, 2019. DOI:10.1007/s00232-019-00075-4

[7] Biggs CI., Stubbs.C., Graham, B., Fayter, AER., Hasan, M., Gibson, MI. Macromolecular Bioscience. Mimicking the Ice Recystallization Activity of Biological Macromolecules. When is a New Polymer 'Active'?, 2019. DOI:10.1002/mabi.201900082

[6] Wilkins, LE., Hasan, M., Fayter, AER., Biggs, CI., Huband, S., Walker, M., Gibson, MI., Polymer Chemistry. Site-Specific Conjugation of Antifreeze Proteins onto Polymer-Stabilized Nanoparticles, 2019. DOI:10.1039/C8PY01719K

[5] Mitchell, DE., Deller, RC., Fayter, AC., Hasan, M., Gutierrez-Marcos, J., Gibson, MI., Materials Horizons. Ice-Recrystallization Inhibiting Polymers Protect Proteins Against Freeze-Stress and Enable Glycerol-Free Cryostorage, 2018. DOI:10.1039/C8MH00727F

[4] Hasan, M., Fayter, AC., Gibson, M.I., Biomacromolecules. Ice Recrystallization Inhibiting Polymers Enable Glycerol-Free Cryopreservation of Micro-organisms, 2018. DOI:10.1021/acs.biomac.8b00660

[3] Blackman, LD., Varlas, S., Arno, M.C., Houston, Z., Fletcher, N., Thurecht, K, Hasan, M., Gibson M.I., and O’Reilly, R.K. Confinement of therapeutic enzymes in selectively permeable polymer vesicles by polymerization-induced self-assembly (PISA) reduces antibody binding and proteolytic susceptibility. ACS Central Science, 2018. DOI:10.1021/acscentsci.8b00168

[2] Ieong, N. S., M. Hasan, D.J. Philips, Y. Saaka, R.K. O’Reilly, and M.I. Gibson. Polymers
with molecular weight dependent LCSTs are essential for cooperative behaviour.
Polymer Chemistry, 2012, 3, 794–799. DOI:10.1039/C2PY00604A

[1] Jenei, Z.A., G.Z.L. Warren, M. Hasan, V.A. Zammit and A.M. Dixon. Packing of transmembrane
domain 2 of carnitine palmitoyltransferase-1A affects oligomerization and
malonyl-CoA sensitivity of the mitochondrial outer membrane protein. The FASEB
Journal, 2011, 25, 4522–4530. DOI:10.1096/FJ.11-192005

Awards

Reach Oxford Scholarship, Magdalen College, University of Oxford, 2004-2007.

Carl Blakey Scholarship, MOAC DTC, University of Warwick, 2010.

Biochemical Society Travel Grant to attend Biophysical Society Annual Meeting, 2019.

Grants

UKRI Innovation Fellowships: BBSRC Flexible Talent Mobility Account Award, 2018.

Conference attendance

The Astbury Conversation, Leeds (UK), 2018

Cryobiology, Madrid (Spain), 2018

Biophysical Society Meeting, Baltimore (USA), 2019

Education

BA (Hons.)

Mathematics, Magdalen College, University of Oxford, 2004-2007

MSc

Mathematical Biology and Biophysical Chemistry, University of Warwick, 2010-2011

PhD

Mathematical Biology and Biophysical Chemistry, University of Warwick, 2011-2015

Email: M.Hasan.1[at]warwick.ac.uk

ORCID ID: orcid.org/0000-0003-3201-7184