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Publications

2020

M. Passmore and M. Jenner. Clicking into place: Interfacing terminal alkyne biosynthesis with polyketide synthases.
Trends Biotechnol., 2020, DOI: 10.1016/j.tibtech.2020.04.001

C. Jones, G. Webster, A.J. Mullins, M. Jenner, M.J. Bull, Y. Dashti, T. Spilker, J. Parkhill, T.R. Connor, J.J. LiPuma, G.L. Challis and E. Mahenthiralingam. Kill and cure: Genomic phylogeny and bioactivity of a diverse collection of Burkholderia gladioli bacteria capable of pathogenic and beneficial lifestyles.
bioRxiv., 2020, DOI: 10.1101/2020.04.09.033878.

2019

Y. Hai, M. Jenner and Y. Tang. Complete stereoinversion of L-tryptophan by a fungal single module nonribosomal peptide synthetase. 
J. Am. Chem. Soc., 2019, 141, 8198-8206.

S. Kosol, A. Gallo, D. Griffiths, T.R. Valentic, J. Masschelein, M. Jenner, E.L.C de los Santos, L. Manzi, P.K. Sydor, D. Rea, S. Zhou, V. Fülöp, N.J. Oldham, S-C. Tsai, G.L. Challis and J.R. Lewandowski. Structural basis for chain release from the enacyloxin polyketide synthase.
Nat. Chem., 2019, 11, 913-923.

M. Jenner. Predicting the peculiar.
Nat. Chem. Biol., 2019, 15, 761-763.

M. Jenner, X. Jian, Y. Dashti, J. Masschelein, C. Hobson, D.M. Roberts, C. Jones, S. Harris, J. Parkhill, H.A. Raja, N.H. Oberlies, C.J. Pearce, E. Mahenthiralingam and G.L. Challis. An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles 'fungal' icosalide antibiotics.
Chem. Sci., 2019, 10, 5489-5494.

A.J. Mullins, J.A.H. Murray, M.J. Bull, M. Jenner, C. Jones, G. Webster, A.E. Green, D.R. Neill, T.R. Connor, J. Parkhill, G.L. Challis and E. Mahenthiralingam. Genome mining identifies cepacin as a key plant-protective metabolite of the biopesticidal bacterium Burkholeria ambifaria.
Nat. Microbiol., 2019, 4, 996-1005.
Featured in News & Views: Uncoupling virulence and biocontrol.
'Behind the Paper' article written by E. Mahenthiralingam.

2018

S. Kosol, M.Jenner, J.R. Lewandowski and G.L. Challis. Protein-protein interactions in trans-AT polyketide synthases.
Nat. Prod. Rep., 2018, 35, 1097-1109.

B. R. K. Menon and M. Jenner. Reprogramming assembly lines.
Nat. Chem., 2018, 10, 245-247.

M. Jenner, S. Kosol , D. Griffiths, P. Prasongpholchai, L. Manzi, A.S. Barrow, J.E. Moses, N.J. Oldham, J.R. Lewandowski  and G.L. Challis. Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthases.
Nat. Chem. Biol., 2018, 14, 270-275.

2017

Nat. Prod. Rep., 2017, 34, 712-783.
Highlighted on the cover.

L. Song, M. Jenner, J. Masschelein, C. Jones, M. Bull, S. Harris, R. Hartkoorn, A. Vocat, I. Romero-Canelón, P. Coupland, G. Webster, M. Dunn, R. Weiser, C. Paisey, S. Cole, J. Parkhill, E. Mahenthiralingam and G.L. Challis. Discovery and biosynthesis of gladiolin: a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis.
J. Am. Chem. Soc., 2017, 138, 7974-7981.
Featured in the Science and Technology section of The Economist (24 June 2017).
Highlighted in an American Chemical Society press release (14 June 2017).

2016

M. Jenner, J.P Afonso, C. Kohlhaas, P. Karbaum, S. Frank, J. Piel and N.J. Oldham. Acyl hydrolases from trans-AT polyketide synthases target acetyl units on acyl carrier proteins.
Chem. Comm., 2016, 52, 5262-5265.
Highlighted in ‘Hot off the Press’ (Nat. Prod. Rep., 2016, 33, 742-746).

K.R. Asiani, H. Williams, L. Bird, M. Jenner, M. S. Searle, J.L. Hobman, D. J. Scott, P. Soultanas. SilE is an intrinsically disordered periplasmic “molecular sponge” involved in bacterial silver resistance.
Mol. Microbiol., 2016, 101, 731-742.
2015

M. Jenner, J. P. Afonso, H. R Bailey, S. Frank, A. Kampa, J. Piel and N.J. Oldham. Acyl‐chain elongation drives ketosynthase substrate selectivity in trans‐acyltransferase polyketide synthases.
Angew. Chem. Intl. Ed., 2015, 54, 1817-1821.
2014

D.C. Gay, G. Gay, A.J. Axelrod, M. Jenner, C. Kohlhaas, A. Kampa, N. J. Oldham, J. Piel, A.T. Keatinge-Clay. A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase.
Structure, 2014, 22, 444-451.
Highlighted on the cover.
2013

M. Jenner, S. Frank, A. Kampa, C. Kohlhaas, P. Pöplau, G.S. Briggs, J. Piel and N.J. Oldham. Substrate specificity in ketosynthase domains from trans‐AT polyketide synthases.
Angew. Chem. Intl. Ed., 2013, 52, 1143-1147.
Highlighted in ‘Hot off the Press’ (Nat. Prod. Rep., 2013, 30, 1272-1276).

M. Jenner. Ion Mobility Mass Spectrometry: Biological Applications.
Encyclopedia of Biophysics., 2013, 1148-1152.

C. Kohlhaas, M. Jenner, A. Kampa, G. S. Briggs, J.P. Afonso, J. Piel, N.J. Oldham. Amino acid-accepting ketosynthase domain from a trans-AT polyketide synthase exhibits high selectivity for predicted intermediate.
Chem. Sci., 2013, 4, 3212-3217.
2011

M. Jenner, J. Ellis, W.C. Huang, E. L. Raven, G. C. K Roberts, N.J. Oldham. Detection of a protein conformational equilibrium by electrospray ionisation‐ion mobility‐mass spectrometry.
Angew. Chem. Intl. Ed., 2011, 50, 8291-8294.

M. Dufour, C. Yan, D. Siegel, M. A. Colucci, M. Jenner, N.J. Oldham, J. Gomez, P. Reigan, Y. Li, C.I. De Matteis, D. Ross, C.J. Moody. Mechanism‐based inhibition of quinone reductase 2 (NQO2): Selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition.
ChemBioChem., 2011, 12, 1203-1208.