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Discovering surface properties with a genomic phage library

We used a genomic phage library to screen novel surfaces for their resistance to nonspecific protein adhesion. We found that tertiary amine N-oxides provide a good level of resistance to phage adhesion.

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Novel Tertiary Amine Oxide Surfaces That Resist Nonspecific Protein Adhesion: Dilly, S. J.; Beecham, M. P.; Brown, S. P.; Griffin J. M.; Clark, A. J.; Griffin, C. D.; Marshall, J.; Napier, R. M.; Taylor, P. C.; Marsh, A.* Langmuir 2006, 22, 8144. DOI:10.1021/la060743j