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Shrina Bhagat

Determination of Active Pharmaceutical Ingredient Release Mechanism of Tablet and Multi-Particulate Formulations during In-Vitro/In-Vivo Dissolution of Oral Medication

PhD Student at the Warwick Electrochemistry and Interfaces Group of the Chemistry Department, under the supervision of Prof. Patrick R. Unwin alongside Prof. Julie V. Macpherson. Research in conjuction with industrial partners Pfizer and AstraZeneca. This research involves investigating the release profile of the electrochemically active drug acetaminophen to determine the breakdown of a reverse enetric polymer coating - the Kollicoat® Smartseal 30 D. The properties of this polymer makes it an effective taste masker of drugs and acts as a moisture barrier. This is particularly useful for pharmaceutical products which have a high drug loading content as well as for paediatric and geriatric patients.

Student-Staff Liaison Committee Representative (SSLC Rep) for the PhD students of the MAS CDT in the Chemistry Faculty as of November 2016.

Experimental Techniques:

  • Electrochemistry
  • Optical Microscopy
  • Scanning Electron Microscopy (SEM)
  • Atomic Force Microscopy (AFM)
  • Electrochemical Imaging - Scanning Ion-Conductance Microscopy (SICM)
    • Dynamic Mechanical Analysis on polymers (DMA) 

    Theoretical Techniques:

    • Mathematical modelling in Matlab
    • Imaging software ImageJ, SPIP™, Adobe Illustrator, ChemDraw

    Academic Qualifications

    PhD Molecular Analytical Science
    MAS CDT, University of Warwick, 2016-Present

    MSc Molecular Analytical Science, Distinction
    MAS CDT, University of Warwick, 2015-2016

    BSc (Hons) in Medicinal Chemistry, 2:1
    University of Surrey, 2010-2014


    Previous Research Projects
    University of Warwick, MSc Research Projects:

    1) Experimental Industrial project with Pfizer - Determination of Active Pharmaceutical Ingredient Release Mechanism of Tablet and Multi-Particulate Formulations during In-Vitro/In-Vivo Dissolution of Oral Medication.

    2) Computational / Theoretical Industrial Project with AstraZeneca - Statistical Data Analysis for Pharmaceutical Manufacturing from a Continuous Twin Screw Granulator.

    University of Surrey, BSc Dissertation Research:
    The analysis of trace elements in foodstuffs, with a particular focus on arsenic in Argentinian rice and fluoride content in various types of tea across the globe and their effects on human health.

    University of Surrey and Grace GmbH & Co.KG, Worms, Germany, Industrial Placement Project:
    The project was to determine a safer way to digest catalysts in order to be analysed by the use of ICP-OES and thereby eliminating the use of hydrofluoric acid in the digestion process. Statistics was used to analyse and compare the two methods of digestion, using the MinitabTM Statistical Software.


    Interests
    • Active member of Warwick Sport and Warwick Indian Classical Dance Society.

    Shrina 2

    Shrina Bhagat

    MAS CDT
    Senate House
    University of Warwick
    Coventry
    CV4 7AL

    Warwick Electrochemistry and Interfaces Group

    📧 S.Bhagat@warwick.ac.uk

    📞 02476 572881

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