2024

• Groves D, Cunnison R, McMahon A, Fan H, Sharps J, Deng A, Keown JR, Fodor E & Robb NC. Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET. BioRxiv. https://doi.org/10.1101/2024.10.15.618435Link opens in a new window
• McMahon A, Vijayakrishnan S, El Sayyed H, Groves D, Conley MJ, Hutchinson E & Robb NC. Engineering stress as a motivation for filamentous virus morphology. Biophysical Reports. https://www.sciencedirect.com/science/article/pii/S2667074724000405Link opens in a new window
• Nagorska A, Tomas RMF, Tasnim A, Robb NC & Gibson MI. Cryopreserved Kidney Epithelial (Vero) Cell Monolayers for Rapid Viral Quantification, Enabled by a Combination of Macromolecular Cryoprotectants. Biomacromolecules. 25(8):5352-5358. 10.1021/acs.biomac.4c00760Link opens in a new window

2023

• McMahon A, Andrews R, Groves D, Ghani SV, Cordes T, Kapanidis AN & Robb NC. High-throughput super-resolution analysis of influenza virus pleomorphism reveals insights into viral spatial organisation. PLOS Pathogens. 19(6): e1011484. https://doi.org/10.1371/journal.ppat.1011484
• Groves D, Hepp C, Kapanidis, AN & Robb NC. Single-molecule FRET for virology: 20 years of insight into protein structure and dynamics. Quarterly Reviews of Biophysics. 56:e3. https://doi.org/10.1017/S0033583523000021Link opens in a new window
• Agam G, Gebhardt C, et int., Cordes, T. Reliability and accuracy of single-molecule FRET studies for the characterization of structural dynamics and distances in proteins. Nature Methods. 20:523–535. https://doi.org/10.1038/s41592-023-01807-0Link opens in a new window

2022

• Shiaelis N, Tometzki A, Peto L, McMahon A, Hepp C, Bickerton E, Favard C , Muriaux D, Andersson M, Oakley S, Vaughan A, Matthews PC, Stoesser N , Crook DW, Kapanidis AN & Robb NC. Virus detection and identification in minutes using single-particle imaging and deep learning. ACS Nano. 17(1):697–710. https://doi.org/10.1021/acsnano.2c10159

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• Robb NC. Virus morphology: Insights from super resolution fluorescence microscopy. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1868(4):166347. https://doi.org/10.1016/j.bbadis.2022.166347Link opens in a new window

2021

• McMahon A, Andrews R, Ghani SV, Cordes T, Kapanidis AN & Robb NC. High-throughput super-resolution analysis of influenza virus pleomorphism reveals insights into viral spatial organisation. BioRxiv. https://www.biorxiv.org/content/10.1101/2021.09.23.461536v2Link opens in a new window

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• Lerner E, Barth A, et int. Weiss S. FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices. eLife. 10:e60416. doi: 10.7554/eLife.60416Link opens in a new window
• Hepp C, Shiaelis N, Robb NC, Vaughan A, Matthews PC, Stoesser N, Crook D & Kapanidis AN. Viral detection and identification in 20 minutes by rapid single-particle fluorescence in-situ hybridization of viral RNA. Scientific Reports. 11(1):19579. doi: 10.1038/s41598-021-98972-zLink opens in a new window

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2020

• Shiaelis N, Tometzki A, Peto L, McMahon A, Hepp C, Bickerton E, Favard C , Muriaux D, Andersson M, Oakley S, Vaughan A, Matthews PC, Stoesser N , Crook D, Kapanidis AN & Robb NC. Virus detection and identification in minutes using single-particle imaging and deep learning. MedRxiv. https://www.medrxiv.org/content/10.1101/2020.10.13.20212035v4Link opens in a new window 

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• McMahon A & Robb NC. Reinfection with SARS-CoV-2: Discrete SIR (Susceptible, Infected, Recovered) Modeling Using Empirical Infection Data. JMIR Public Health Surveill. 6(4):e21168. doi: 10.2196/21168Link opens in a new window

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2019

• Robb NC, Taylor JM, Kent A, Pambos O, Gilboa B, Kapanidis AN. Rapid functionalisation and detection of viruses via a novel Ca2+-mediated virus-DNA interaction. Scientific Reports. 9(1):16219. doi: 10.1038/s41598-019-52759-5Link opens in a new window

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• Robb NC, te Velthuis AJW, Fodor E, Kapanidis AN. Real-time analysis of single influenza virus replication complexes reveals large promoter-dependent differences in initiation dynamics. Nucleic Acids Research. 47(12):6466-6477. doi: 10.1093/nar/gkz313Link opens in a new window

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2018

• Hepp C & Robb NC. Coming together during viral assembly. Nature Reviews Microbiology. 16(12):721. doi: 10.1038/s41579-018-0102-4Link opens in a new window
• Hellenkamp B, Schmid S, et int., Hugel T. Precision and accuracy of single-molecule FRET measurements-a multi-laboratory benchmark study. Nature Methods. 15(9):669-676. doi: 10.1038/s41592-018-0085-0Link opens in a new window
• Duchi D, Gryte K, Robb NC, Morichaud Z, Sheppard C, Brodolin K, Wigneshweraraj S, Kapanidis AN. Conformational heterogeneity and bubble dynamics in single bacterial transcription initiation complexes. Nucleic Acids Research. 46(2):677-688. doi: 10.1093/nar/gkx1146Link opens in a new window

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2016

• Robb NC, te Velthuis AJW, Wieneke R, Tampè R, Cordes T, Fodor E, Kapanidis AN. Single-molecule FRET reveals the pre-initiation and initiation conformations of influenza virus promoter RNA. Nucleic Acids Research. 44(21):10304-10315. doi: 10.1093/nar/gkw884Link opens in a new window
• Duchi D, Bauer DLV, Fernandez L, Evans G, Robb NC, Hwang LC, Gryte K, Tomescu A, Zawadski P, Morichaud Z, Brodolin K, Kapanidis AN. RNA polymerase pausing during initial transcription. Molecular Cell. 63(6):939-50. doi: 10.1016/j.molcel.2016.08.011Link opens in a new window
• Te Velthuis AJW, Robb NC, Kapanidis AN, Fodor E. The role of the priming loop in Influenza A virus RNA synthesis. Nature Microbiology. 1:16029. doi: 10.1038/nmicrobiol.2016.29Link opens in a new window

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2014

• Tomescu AI*, Robb NC*, Hengrung N, Fodor E, Kapanidis AN. Single-molecule FRET reveals a corkscrew RNA structure for the polymerase-bound influenza virus promoter. PNAS. 111(32):E3335-42. doi: 10.1073/pnas.1406056111Link opens in a new window (*Joint first authors)

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2013

• Robb NC*, Cordes T*, Hwang LC*, Gryte K, Duchi D, Craggs TD, Santoso Y, Weiss S, Ebright RH, Kapanidis AN. The transcription bubble of the RNA polymerase-promoter open complex exhibits conformational heterogeneity and millisecond-scale dynamics: implications for transcription start-site selection. J Mol Biol. 425(5):875-85. doi: 10.1016/j.jmb.2012.12.015Link opens in a new window (*Joint first authors)

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2012

• Wise HM, Hutchinson EC, Jagger BW, Stuart, AD, Kang ZH, Robb NC, Kash JC, Fodor, E, Firth AE, Gog JR, Taubenberger JK and Digard P. Identification of a novel splice variant form of the influenza a virus M2 ion channel. PLoS Pathogens. 8(11): e1002998. doi: 10.1371/journal.ppat.1002998Link opens in a new window
• Robb NC and Fodor E. The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein. J Gen Virol . 93(Pt 1):113-8. doi: 10.1099/vir.0.035485-0Link opens in a new window

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2011

• Robb NC, Chase G, Bier K, Vreede FT, Shaw P, Naffakh N, Schwemmle M, Fodor E. The influenza A NS1 protein interacts with the nucleoprotein of viral ribonucleoprotein complexes. J Virol. 85(10):5228-31. doi: 10.1128/JVI.02562-10Link opens in a new window

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2010

• Wang Z, Robb NC, Lenz E, Wolff T, FodorE, Pleschka S. Reassortment of the NS segment of an H7-type HPAIV affects its propagation by altering the regulation of viral RNA production and the anti-viral host response. J. Virol . 84(21):11323-35. doi: 10.1128/JVI.01034-10Link opens in a new window
• Robb NC, Jackson D, Vreede FT and Fodor E. Splicing of influenza A virus NS1 mRNA is independent of the viral NS1 protein. J Gen Virol. 91(Pt 9):2331-40. doi: 10.1099/vir.0.022004-0Link opens in a new window
• Chan W, Ng A, Robb NC, Lam M, Chan P, Au S, Fodor E, Shaw P. Functional analysis of influenza H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities. J. Virol . 84(14):7337-45. doi: 10.1128/JVI.02474-09Link opens in a new window
• Rehwinkel J, Tan CP, Goubau D, Schulz O, Pichlmair A, Bier K, Robb NC, Vreede F, Barclay W, Fodor E, Reis e Sousa C. RIG-I detects viral genomic RNA during negative strand RNA virus infection. Cell. 140(3):397-408. doi: 10.1016/j.cell.2010.01.020Link opens in a new window

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2009

• Robb NC*, Smith M*, Vreede FT, Fodor E. (2009) The NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome. J Gen Virol. 90(Pt 6):139. (*Joint first authors). doi: 10.1099/vir.0.009639-0Link opens in a new window

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Outreach Articles

• The beating heart of the flu virus & and why scientists want to commandeer itLink opens in a new window

Aartjan te Velthuis & Nicole Robb

The Conversation, 2016.

• Can Science conquer the flu virus?Link opens in a new window

Aartjan te Velthuis & Nicole Robb

World Economic Forum, 2016.

•  Do you have to be a doctor to cure diseases? Using lasers to light up single virus moleculesLink opens in a new window

Nicole Robb

Oxplore, 2019.

• Science on the HillLink opens in a new window - a virtual science outreach evening to discuss some of the science behind Covid-19

Nicole Robb

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Selected Media Articles

• https://www.thetimes.co.uk/article/flu-is-an-enemy-that-never-stops-evolving-90r9lwsh6
• https://www.newscientist.com/article/2279407-first-human-case-of-h10n3-bird-flu-strain-reported-in-china/
• https://www.biosciencetoday.co.uk/advanced-testing-is-vital-to-prevent-bird-flu-pandemic/
• https://www.htworld.co.uk/leadership/opinion/advanced-diagnostic-testing-is-crucial-for-preventing-an-avian-flu-pandemic-ta23/?amp=1
• https://www.mirror.co.uk/news/health/new-test-revolutionise-detection-viruses-29617753
• https://www.healtheuropa.com/using-ai-to-develop-diagnostic-technologies/121997/
• https://www.standard.co.uk/news/health/bird-flu-pandemic-avian-britain-b1068579.html
• https://www.dailymail.co.uk/news/article-11714389/The-facial-recognition-virus-detector-herald-end-intrusive-Covid-tests.html
• https://www.dailymail.co.uk/health/article-11515997/Britain-roll-Covid-style-LATERAL-FLOW-tests-Strep-experts-say.html
• https://metro.co.uk/2022/12/07/wakefield-hospital-ran-out-of-antibiotics-in-girls-strep-a-scare-17893391/
• https://www.express.co.uk/news/uk/1705467/strep-a-children-s-throat-infection-scarlet-fever-rsv-nhs-flu-covid-health
• https://www.express.co.uk/news/science/1771245/bird-flu-uk-cases-humans
• https://inews.co.uk/news/health/bird-flu-dangerous-humans-shouldnt-worry-uk-cases-2347637