Before joining the MOAC DTC I gained a MMath qualification from the university of Warwick.
During my first year the three mini-projects undertaken were:
Monte Carlo Markov Chain techniques for assigning parameters to regulatory networks. Alex Morton (Statistics)
Investigating the effect of entrainment upon phase in the circadian clock of Arabidopsis thaliana. Laszlo Kozma-Bognar (Biology)
Development of a scanning ion conductance microscope (SICM). Julie Macpherson (Chemistry).
My PhD was a continuation of my third mini-project. I shall continue to develop the SICM and aim to apply it and other techniques, such as scanning electrochemical microscopy (SECM), microarrays, stable isotope labelling with amino acids in cell culture (SILAC) -proteomics- and optical microscopy, to study a model system for placental trophoblast cells, BeWo cells. I am to study the effect of oxidative stress in the process of sycitialisation with an aim to improve understanding of the condition of pregnancy known as pre-eclampsia. I am co-supervised by Anna Whitworth, Patrick Unwin (both Chemistry) and Manu Vatish (Medical School).
I have authored on the following papers:
Scanning electrochemical microscopy: principles and applications to biophysical systems Martin A. Edwards, Sophie Martin, Anna L. Whitworth, Julie V. Macpherson and Patrick R. Unwin Physiological Measurement, 2006, 27, R63-R108
Scanning Ion Conductance Microscopy: a Model for Experimentally Realistic Conditions and Image Interpretation Martin A. Edwards, Cara G. Williams, Anna L. Whitworth, and Patrick R. Unwin, Anal. Chem., 2009, 81 (11), 4482–4492.
Slow Diffusion Reveals the Intrinsic Electrochemical Activity of Basal Plane Highly Oriented Pyrolytic Graphite Electrodes Martin A. Edwards, Paolo Bertoncello, and Patrick R. Unwin, J. Phys. Chem. C, 2009, 113, 9218–9223.
Silver Particle Nucleation and Growth at Liquid/Liquid Interfaces: A Scanning Electrochemical Microscopy Approach F. Li, M. Edwards, J. Guo and P. R. Unwin, J. Phys. Chem. C, 2009, 113(9), 3553–3565.
Scanning Micropipet Contact Method for High-Resolution Imaging of Electrode Surface Redox Activity C. G. Williams, M. A. Edwards, A. L. Colley, J. V. Macpherson, and P. R. Unwin, Anal. Chem., 2009, 81(7), 2486–2495.
Scanning Electrochemical Microscopy as a Quantitative Probe of Acid-Induced Dissolution: Theory and Application to Dental Enamel
C-A. McGeouch, M. A. Edwards, M. Mbogoro, C. Parkinson & P. R. Unwin, Anal. Chem.,2010, 82 (22), 9233-9328.
Localized High Resolution Electrochemistry and Multifunctional Imaging: Scanning Electrochemical Cell Microscopy
N. Ebejer, M. Schnippering, A. W. Colburn, M. A. Edwards & P. R. Unwin, Anal. Chem.,2010, 82 (22), 9141-9145.
Intermittent Contact-Scanning Electrochemical Microscopy (IC-SECM): A New Approach for Tip Positioning and Simultaneous Imaging of Interfacial Topography and Activity
K. McKelvey, M. A. Edwards and P. R. Unwin, Anal. Chem., 2010, 82 (15), 6334-6337.
M. A. Edwards, A. L. Whitworth & P. R. Unwin, Anal. Chem., 2011, 83, 1977-1984.
The first paper should give a good introduction to and thorough overview of the SECM's application to biological areas. The others are characteristic of much of the work I do using combining experimental methods with mathematical models to help understand physical problems.
Following my PhD I was a postdoctoral researcher jointly supervised by Julie Macpherson and Greg Challis in the department of chemistry at the university of Warwick
From July '09 Until August 2011 I was a postdoc at the Institute for Bioengineering of Catalonia (IBEC) an interdisciplinary research centre in Barcelona working for Dr.s Gabriel Gomila and Antonio Juarez in the areas of Nanoscale bioelectrical characterization
and Microbial biotechnology and host-pathogen interaction My work there involved the performing and interpretting (typically though modelling approaches) electrical AFM experiments. The work aims to perform quantitative electrical imaging of bacteria and biological systems.
I am currently a post-doctoral researcher at the University of North Carolina at Chapel Hill in the group of R Mark Wightman. Our work involves looking into the chemistry of brain. We aim to make high temporal resolution measurements of neurotransmitters and related this information to physiological and behavioural measurements. Please see our group website for more details.