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George Hughes

2014 - Present: PhD, University of Warwick

PhD - Design and mechanism of action of novel anticancer organoiridium complexes for lymphoma.

Supervisors: Prof. Peter Sadler (Chemistry) and Prof. Lawrence Young (Warwick Medical School, Pro-Vice-Chancellor)

This PhD project involves the synthesis and characterisation of novel and optimised Ir(III) complexes that can expand the range of treatable cancers by exploiting the redox modulation that these complexes can achieve in cancer cells. ​ The cytotoxicity of the novel Ir(III) complexes will be investigated in a panel of EBV-positive and negative BL, and HL cell lines. The relationship with ROS levels in these cells will be investigated. Studies examining the various cell signalling and transcriptional pathways (NRF2, HIF-1a, AP-1, NF-kB, PI3-kinase) will also be included alongside specific examination of the effects of individual EBV latent genes.

Travelled to China as part of a collaboration with SYSU Cancer Center in Guangzhou testing my drugs against a variety of their cell lines.

During this trip I attended the ICBIC International Conference in Beijing and presented a poster and gave a talk to an audience of ~500 describing my work.

2013 - 2014: MSc, Mathematical Biology and Biophysical Chemistry (Merit), University of Warwick

Modules Included:

Cellular systems and biomolecules

Mathematical Models of Biological Systems

Introduction to chemical aspects of biological systems

Techniques for the characterisation of biomolecules

Microscopy and Imaging

Numerical methods for Modelling

Molecular modelling

Quantitative biology

Statistics for Data Analysis

Warwick Interdisciplinary Science Transferable Skills

Plus three 8-week miniprojects:

Biophysical Miniproject - Acetolactate decarboxylase (ALDC) selective active-site binder synthesis. (Project consisted of synthetic organic chemistry, analytical chemistry and X-ray crystallography) Supervisor: Prof. Martin Wills & Prof. Vilmos Fulop.

Theoretical Miniproject - Analysis of TCR sequencing data. (Project consisted of programming in C++ and statistical analysis of large datasets in R) Supervisor: Dr. Sascha Ott & Dr. Nigel Dyer

Experimental Miniproject - Medicinal chemistry of syncytial virus inhibitors. (Project consisted of cell biology, virology and computational chemistry for drug screening in silico) Supervisors: Prof. Andrew Easton, Dr. Andrew marsh and Dr. Philip Gould

2010 - 2013: BSc (Hons), Biochemistry (Upper second-class), University of Warwick

Modules Included:

Molecular Biology, Organic Chemistry, Physical Chemistry, Biophysical Chemistry
Biological Spectroscopy, Biostatistics, Advanced Immunology, Oncology and Post-Genomic research.

Completed Labs in Structural Biology, Microbiology, Post Genomic Research, Bioenergetics.

Undertook a final year project in Immunology involving particle gun mediated cell transformation and confocal microscopy

Personal Interests

, I'm glad you asked.
My personal interests include taekwondo, in which I have been part of the Warwick Taekwondo exec as well as competing in many tournaments and winning a great deal of sparring medals. I am a black belt and have been practising taekwondo for over 12 years.
My other main passion is drumming in which I have performed around the country both solo and in various heavy metal bands.

I am somewhat fond of scarves.