PhD - Design and mechanism of action of novel anticancer organoiridium complexes for lymphoma.
Supervisors: Prof. Peter Sadler (Chemistry) and Prof. Lawrence Young (Warwick Medical School, Pro-Vice-Chancellor)
This PhD project involves the synthesis and characterisation of novel and optimised Ir(III) complexes that can expand the range of treatable cancers by exploiting the redox modulation that these complexes can achieve in cancer cells. The cytotoxicity of the novel Ir(III) complexes will be investigated in a panel of EBV-positive and negative BL, and HL cell lines. The relationship with ROS levels in these cells will be investigated. Studies examining the various cell signalling and transcriptional pathways (NRF2, HIF-1a, AP-1, NF-kB, PI3-kinase) will also be included alongside specific examination of the effects of individual EBV latent genes.
Travelled to China as part of a collaboration with SYSU Cancer Center in Guangzhou testing my drugs against a variety of their cell lines.
During this trip I attended the ICBIC International Conference in Beijing and presented a poster and gave a talk to an audience of ~500 describing my work.
2013 - 2014: MSc, Mathematical Biology and Biophysical Chemistry (Merit), University of Warwick
Cellular systems and biomolecules
Mathematical Models of Biological Systems
Introduction to chemical aspects of biological systems
Techniques for the characterisation of biomolecules
Microscopy and Imaging
Numerical methods for Modelling
Statistics for Data Analysis
Warwick Interdisciplinary Science Transferable Skills
Plus three 8-week miniprojects:
Biophysical Miniproject - Acetolactate decarboxylase (ALDC) selective active-site binder synthesis. (Project consisted of synthetic organic chemistry, analytical chemistry and X-ray crystallography) Supervisor: Prof. Martin Wills & Prof. Vilmos Fulop.
Theoretical Miniproject - Analysis of TCR sequencing data. (Project consisted of programming in C++ and statistical analysis of large datasets in R) Supervisor: Dr. Sascha Ott & Dr. Nigel Dyer
Experimental Miniproject - Medicinal chemistry of syncytial virus inhibitors. (Project consisted of cell biology, virology and computational chemistry for drug screening in silico) Supervisors: Prof. Andrew Easton, Dr. Andrew marsh and Dr. Philip Gould
2010 - 2013: BSc (Hons), Biochemistry (Upper second-class), University of Warwick
Molecular Biology, Organic Chemistry, Physical Chemistry, Biophysical Chemistry
Biological Spectroscopy, Biostatistics, Advanced Immunology, Oncology and Post-Genomic research.
Completed Labs in Structural Biology, Microbiology, Post Genomic Research, Bioenergetics.
Undertook a final year project in Immunology involving particle gun mediated cell transformation and confocal microscopy
I am somewhat fond of scarves.