Skip to main content Skip to navigation

Anthony Knight

Current research


I am developing a Quantitative Systems Pharmacology approach to understand the kinetics underlying GPCR activation. Using both experimental and mathematical techniques I hope to understand how ligands influence various GPCR-G protein interactions. This approach can be applied to a range of GPCRs to better understand and avoid off-target drug interactions.


Research interests

  • GPCR pharmacology

  • Quantitative systems pharmacology

  • Cell signalling

  • Human health and disease

Research experience

 

Previous research

Current research

  • "A Systems Pharmacology Approach to the Adenosine A1 Receptor" - PhD Thesis

  • Novel adenosine receptor fluorescent agonist development and screening



Education


2011-2014 University of Warwick

PhD Systems Biology

Thesis title - "A Systems Pharmacology Approach to the Adenosine A1 Receptor".

2010-2011 University of Warwick

MSc Systems Biology (Distinction)

2006-2010 Cardiff University

BSc (Hons) Biochemistry (Sandwich course)


Publications, conferences and abstracts

  • "A Systems Pharmacology Approach to GPCRs". ID2 Oxford. July 2014. Poster prize awarded

  • "Computational modelling to aid drug discovery in GPCRs". BPS Pharmacology 2013, London. December 2013.
  • "A Quantitative Systems Pharmacology Approach to the Adenosine A1 Receptor". Molecular Pharmacology of G Protein-Coupled Receptors Meeting, Monash. December 2012.

  • "Modelling the Pharmacodynamics of the Adenosine A1 Receptor". 4th BPS Focused Meeting on Cell Signalling, Leicester. April 2012.

  • "Modelling the Pharmacokinetics of the Adenosine A1 Receptor". Keystone Symposia on Molecular and Cellular Biology, Calgary. February 2012.

  • "Investigating Cell-To-Cell Variation in a Heterogenous Population Using Multiple Fluorescent Reporters". Annual Warwick Systems Biology Conference, Stratford. July 2011.


Teaching and public engagement activity

2015 - Arden Tutoring - GCSE and A-Level Science and Mathematics

2014 - IGGY Student Mentor

2014 - Realising Opportunities Widening Participation Scheme

2013 - The Big Bang Fair West Midlands

2013 - Interdisciplinery Biomedical Research (IBR) PhD

2012 - Systems Biology MSc

2011 - Higher Education Access Programme for Schools (HEAPS) programme

 

imgp0047.jpg

Contact

Systems Biology Doctoral Training Centre

Top Floor

Senate House

University of Warwick

CV4 7AL

anthony.knight@warwick.ac.uk


Funding

Research funded by the EPSRC via the Systems Biology Doctoral Training Centre.