Anthony Knight

Current research

I am developing a Quantitative Systems Pharmacology approach to understand the kinetics underlying GPCR activation. Using both experimental and mathematical techniques I hope to understand how ligands influence various GPCR-G protein interactions. This approach can be applied to a range of GPCRs to better understand and avoid off-target drug interactions.

Research interests

GPCR pharmacology

Quantitative systems pharmacology

Cell signalling

Human health and disease

Research experience

Previous research

The effect of Epstein-Barr virus on the adaptive immune response
Crystallisation mechanisms of antimalarial pesticides
Investigating cell-to-cell variation in a heterogenous population using multiple fluorescent reporters
Modelling nanoparticle-mediated delivery of antimalarials
Organo-metallic complexes as anticancer therapeutics

Current research

"A Systems Pharmacology Approach to the Adenosine A₁ Receptor" - PhD Thesis
Novel adenosine receptor fluorescent agonist development and screening

Education

2011-2014 University of Warwick

PhD Systems Biology

Thesis title - "A Systems Pharmacology Approach to the Adenosine A₁ Receptor".

2010-2011 University of Warwick

MSc Systems Biology (Distinction)

2006-2010 Cardiff University

BSc (Hons) Biochemistry (Sandwich course)

Publications, conferences and abstracts

"A Systems Pharmacology Approach to GPCRs". ID² Oxford. July 2014. Poster prize awarded
"Computational modelling to aid drug discovery in GPCRs". BPS Pharmacology 2013, London. December 2013.
"A Quantitative Systems Pharmacology Approach to the Adenosine A₁ Receptor". Molecular Pharmacology of G Protein-Coupled Receptors Meeting, Monash. December 2012.
"Modelling the Pharmacodynamics of the Adenosine A₁ Receptor". 4th BPS Focused Meeting on Cell Signalling, Leicester. April 2012.
"Modelling the Pharmacokinetics of the Adenosine A₁ Receptor". Keystone Symposia on Molecular and Cellular Biology, Calgary. February 2012.
"Investigating Cell-To-Cell Variation in a Heterogenous Population Using Multiple Fluorescent Reporters". Annual Warwick Systems Biology Conference, Stratford. July 2011.

Teaching and public engagement activity

2015 - Arden Tutoring - GCSE and A-Level Science and Mathematics

2014 - IGGY Student Mentor

2014 - Realising Opportunities Widening Participation Scheme

2013 - The Big Bang Fair West Midlands

2013 - Interdisciplinery Biomedical Research (IBR) PhD

2012 - Systems Biology MSc

2011 - Higher Education Access Programme for Schools (HEAPS) programme

Contact

Systems Biology Doctoral Training Centre

Top Floor

Senate House

University of Warwick

CV4 7AL

anthony.knight@warwick.ac.uk

Funding

Research funded by the EPSRC via the Systems Biology Doctoral Training Centre.