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Chemistry Peter J. Sadler Group

Sadler Group Christmas 2019



Selected Publications

COVER ARTICLE

Metallation-Induced Heterogeneous Dynamics of DNA Revealed
by Single-Molecule FRET

Raul Berrocal-Martin, Carlos Sanchez-Cano, Cookson K. C. Chiu, Russell J. Needham,
Peter J. Sadler, and Steven W. Magennis

Chem. Eur. J. 2020, 26, 4980 – 4987

https://doi.org/10.1002/chem.202000458

 

X-ray Tomography of Cryopreserved Human Prostate Cancer Cells: Mitochondrial Targeting by an Organo-Iridium Photosensitizer

E. M. Bolitho, C. Sanchez-Cano, H. Huang, I. Hands-Portman, M. Spink, P. D. Quinn, M. Harkiolaki, P. J. Sadler

J. Biol. Inorg. Chem. 2020, 25, 295-303

doi: 10.1007/s00775-020-01761-8

 

150 Years of the Periodic Table: new medicines and diagnostic agents

C. Imberti and P.J. Sadler

Advances in Inorganic Chemistry 2020, vol 75, pages 3-56

Free download until 29 March 2020: https://authors.elsevier.com/b/1aXmO3COUolcQs

New designs for phototherapeutic transition metal complexes

C. Imberti, P. Zhang, H. Huang, P.J. Sadler

Angew Chem. Int. Ed. 2020, 59, 61-73

https://doi.org/10.1002/anie.201905171

Targeted photoredox catalysis in cancer cells

Huang, S. Banerjee, K. Qiu, P. Zhang, O. Blacque, T. Malcomson, M.J. Paterson, G.J. Clarkson, M. Staniforth, V.G. Stavros, G. Gasser, H. Chao, P.J. Sadler

Nature Chem., 2019, 11, 1041-1048

DOI : 10.1038/s41557-019-0328-4

Nanofocused synchrotron x-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells

Sanchez-Cano, D. Gianolio, I. Romero-Canelon, R. Tucoulou, P.J. Sadler

Chem. Comm. 2019, 55(49):7065-7068.

doi: 10.1039/c9cc01675a

Nucleus-targeted organoiridium-albumin conjugate for photodynamic cancer therapy

Zhang, H. Huang, S. Banerjee, G.J. Clarkson, C. Ge, C. Imberti, P.J. Sadler

Angew. Chem. Int. Ed. 2019, 58, 2350-2354.

https://doi.org/10.1002/anie.201813002

Photoactivatable platinum anticancer complex can generate tryptophan radicals

Vallotto, E. Shaili, H. Shi, J.S. Butler, C.J. Wedge, M.E. Newton, P.J. Sadler

Chem. Comm. 2018, 54, 13845-13848.

DOI: 10.1039/C8CC06496B

Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity

Chen, J. Moat, D. McFeely, G. Clarkson, I.J. Hands-Portman, J.P. Furner-Pardoe, Freya Harrison, C.G. Dowson, P.J. Sadler

J. Med. Chem. 2018, 61(16), 7330-7344.

DOI: 10.1021/acs.jmedchem.8b00906

New Activation Mechanism for Half-sandwich Organometallic Anticancer Complexes

Banerjee, J.J. Soldevila-Barreda, J.A. Wolny, C.A. Wootton, A. Habtemariam, I. Romero-Canelón, F. Chen, G.J. Clarkson, I. Prokes, L. Song, P.B. O’Connor, V. Schünemann, P.J. Sadler

Chemical Science 2018, 9, 3177-3185.

DOI: 10.1039/C7SC05058E

Sequence-Dependent Attack on Peptides by Photoactivated Platinum Anticancer Complexes

C.A. Wootton, C. Sanchez-Cano, A.F. Lopez-Clavijo, E. Shaili, M.P. Barrow, P.J. Sadler, P.B. O’Connor

Chemical Science 2018, 9, 2733-2739.

DOI: 10.1039/C7SC05135B

Mitochondria-targeted spin-labelled luminescent iridium anticancer complexes

Venkatesh, R. Berrocal-Martin, C.J. Wedge, I. Romero-Canelón, C. Sanchez-Cano, J.-I. Song, J.P.C. Coverdale, P. Zhang, G.J. Clarkson, A. Habtemariam, S.W. Magennis, R.J. Deeth, P.J. Sadler

Chemical Science 2017, 8, 8271- 8278

DOI: 10.1039/C7SC03216A

 

Organo-iridium photosensitizers can induce specific oxidative attack on proteins in cancer cells

Zhang, C.K.C. Chiu, H. Huang, Y.P.Y. Lam, A. Habtemariam, T. Malcomson, M.J. Paterson, G.J. Clarkson, P.B.O’Connor, H. Chao, P.J. Sadler

Angew. Chem. Int. Ed. 2017, 56, 14898–14902

DOI: 10.1002/ange.201710973

 

Asymmetric transfer hydrogenation by synthetic catalysts in cancer cells

J.P.C. Coverdale, I. Romero-Canelón, C. Sanchez-Cano, G.J. Clarkson, A. Habtemariam, M. Wills, P.J. Sadler

Nature Chem. 2018, 10, 347-354.

DOI : 10.1038_nchem.2918

http://dx.doi.org/10.1038_nchem.2918

 

Supramolecular photoactivatable anticancer hydrogels

Venkatesh, N. Kumar Mishra, I. Romero-Canelón, R.R. Vernooij, H. Shi, J.P.C. Coverdale, A. Habtemariam, S. Verma, P.J. Sadler

J. Amer. Chem. Soc. 2017, 139, 5656−5659.

DOI: 10.1021/jacs.7b00186

 

Synchrotron x-ray fluorescence nanoprobe reveals target sites for organo-osmium complex in human ovarian cancer cells

Sanchez-Cano, I. Romero-Canelón, Y. Yang, I.J. Hands-Portman, S. Bohic, P. Cloetens, P.J. Sadler

Chem. Eur. J. 2017, 23, 2512–2516.

DOI: 10.1002/chem.201605911

 

In-Cell Activation of Organo-Osmium(II) Anticancer Complexes

R.J. Needham, C. Sanchez-Cano, X. Zhang, I. Romero-Canelón, A. Habtemariam, M.S. Cooper, L. Meszaros, G.J. Clarkson, P.J. Blower, P.J. Sadler

Angew. Chem. Int. Ed. 2017, 56, 1017 –1020

 

Combatting AMR: photoactivatable ruthenium(II)-isoniazid complex exhibits rapid selective antimycobacterial activity

N.A. Smith, P. Zhang, S.E. Greenough, M.D. Horbury, G.J. Clarkson, D. McFeely, A. Habtemariam, L. Salassa, V.G. Stavros, C.G. Dowson, P.J. Sadler

Chemical Science, 2017, 8, 395 - 404

DOI: 10.1039/C6SC03028A

 

Os2-Os4 switch controls DNA knotting and anticancer activity

Fu, M.J. Romero, L. Salassa, X. Cheng, A. Habtemariam, G.J. Clarkson, I. Prokes, A. Rodger, G. Costantini, P.J. Sadler

Angew. Chem. Int. Ed. 2016, 55, 8909-12.

DOI: 10.1002/anie.201602995R1 and 10.1002/ange.201602995R1