Research Interests

My research is focused on mass spectrometry based metabolomics and proteomics, their applications in areas including natural product drug discovery, drug metabolism, disease biomarker discovery and environmental analysis.

• Bioactive natural product discovery from microorganism and plant, using a combination of liquid chromatography, high resolution high accuracy MS, MS/MS, 1D and 2D NMR techniques, we carry out dereplication, identification, purification and structure elucidation of novel bioactive natural products.
• Drug mechanism of action and metabolism analysis (ADME, pharmacokinetics), using stable isotope labelled drugs to investigate drug metabolism in both in vitro and in vivo systems, metabolites are identified through high resolution LC-MS/MS profiling, both the original drug and their metabolites can be quantified in MRM mode with triple quadrupole mass spectrometer for pharmacokinetic and pharmacodynamic evaluation.
• Disease biomarker discovery and validation (for diagnosis, therapeutic and pharmacodynamics study) using comparative metabolomic and proteomic approach.
• Environmental analysis of both organic and inorganic pollutants (agrochemicals such as pesticide, herbicides, veterinary antimicrobials, animal growth hormones, their leakage into the environment; human medicine and breakdown products entering the environment from waste water treatment plant) and environment originated antimicrobial resistance.