Dr Martin Davey
Supervisor Details
Research Interests
The vertebrate immune system has evolved to ensure host survival from pathogenic microbes. The immune system is a highly specialised network of cells, organs, receptors and soluble factors that protects the host from infection and cancer, while also promoting healthy tissues. The adaptive immune system – responsible for generating memory to past infections - has retained a tripartite cellular network of B cells, αβ T-cells and γδ T-cells for ~450 million years of vertebrate evolution.
We know a lot about “conventional” β T-cells, but while “unconventional” γδ Tcells are frequently implicated in anti-bacterial, anti-viral and anti-parasitic immunity, the mechanisms that this group of immune cells employs to communicate and control these infections is almost completely unclear.
My lab investigates the role of these human γδ T-cells across tissues, life and infections (malaria, tuberculosis and viruses).
MIBTP Project Details
Co-supervisor on a project with Professor Meera Unnikrishnan.