AMR in Gut Microbiota
My PhD project focused on gut microbiota metabolism of dietary constituents (e.g. choline) and the impact on cardiovascular diseases.
In a recent paper that I co-authored, we demonstrated that choline metabolism significantly increased swarming speed of the model bacterium, Proteus mirabilis and swarmer cells have an elevated resistance to antibiotics.
The aim of this project is to characterize subpopulation to single- cell resolution of swarming cell response to antibiotics. Specifically, I aim to investigate the intriguing link of choline metabolism, enhanced swarming and subsequently enhanced antimicrobial resistance using P. mirabilis as the model, and test the hypothesis that choline enhances swarming speed and thus elevated resistance to antibiotics.
School of Life Sciences
Gibbet Hill Campus
The University of Warwick