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Dr Shirin Jamshidi




Research Interests

Computational Nanomedicine, Biophysics & Biochemistry


Research Summary

Currently in the Biophysical Chemistry research group at the University of Warwick my primary research goal is directed toward understanding of the different binding modes of interaction between DNA and dyes as anticancer targets using computational and spectroscopic methods. Also I perform molecular dynamics simulation, molecular docking, protein-protein interaction and homology modelling for supporting some other projects.

As a PhD student in major of Medical Nanotechnology (2013) at Shahid Beheshti University of Medical Sciences at Tehran under supervision of Prof. Hashem Rafii-Tabar, I studied the catalytic mechanism of Orotidine 5’-monophosphate decarboxylase (ODCase) enzyme by molecular dynamics, molecular docking and MM-PBSA/MM-GBSA calculations. Also as a MSc student in Biochemistry I investigated treatment of the diabetes by purification of beta cells of pancreas from non diabetic rats and transplantation into the immunoisolated sites of diabetic rats.


Selected Publications​


1. Agnes Mihalyi, Shirin Jamshidi, Justinas Slikas, Timothy DH Bugg. Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: isoquinoline alkaloid michellamine B and xanthene dye phloxine B. Bioorganic & Medicinal Chemistry 2014;22(17) 4566-4571

2. Shirin Jamshidi, Seifollah Jalili, Hashem Rafii-Tabar. Study of Orotidine 5’-Monophosphate Decarboxylase in Complex with the Top Three OMP, BMP and PMP Ligands by Molecular Dynamics Simulation. Journal of Biomolecular Structure and Dynamics 2014; 33(2) 404–417

3. Shirin Jamshidi, Hashem Rafii-Tabar, Seifollah Jalili. Investigation into mechanism of orotidine 5-monophosphate decarboxylase enzyme by MM-PBSA/MM-GBSA and molecular docking. Molecular simulation 2013; 40(6) 469-476.


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