Our research is mainly based upon the use of free radicals in organic synthesis and polymer chemistry. We develop new methodology for mediating radical reactions with control of regio- and stereochemistry using green chemistry. We have developed a range of copper based catalysts to facilitate C-C bond formation in cyclisation reactions. We also have an interest in the chemistry of hydroxamic acids and organozirconium chemistry.
Targets: Heterocycles, atropisomeric enamides, beta-lactams, gamma-lactams, phenanthridine alkaloids, L-755807, trikendiol, kainic acids, indolizidines, oxindoles and strained bicyclo gamma-lactam derivatives. For a publication list see here:
For more specific examples of our research see:
Copper catalysed atom transfer radical cyclisation. Key paper.
CuSO4.5H2O in C/C bond formation. Key paper.
Catalysts for atom transfer radical cyclisation. Key paper
Atropisomeric enamides and their use in asymmetric chemistry. Key paper
Beta-lactam synthesis. Key paper.
Solid supported reagents for radical reactions. Key paper.
Novel 5-endo radical-polar crossover reactions. Key paper.
Amidyl Radical Cyclisations.Key Paper.
Novel triple crossover reactions to trikendiol skeleton. Coming soon-hopefully!
Prof. Mark Smith
Dr. David Fox
Prof. Robert Deeth