Background

PhD in the Chemistry Department under the supervision of Ann Dixon, Warwick University (2014-2018)

MSc in Drug Development, University of Navarra, Spain (2012-2013)

BSc, MSc in Biotechnology, University of Salamanca, Spain (2007-2012)

About my PhD

Siglecs are carbohydrate binding proteins (lectins) expressed by human immune system (IS) cells. They have been highlighted as interesting pharmacological targets for IS-related diseases (Macauley, et al., 2014).

My project is a collaboration with the biotech company Mologic Ltd aiming to design small molecules that target Siglecs.

It involved:

- Molecular Biology techniques to clone, express, refold and purify soluble Siglec carbohydrate binding domains:

- Biophysical techniques for protein characterization (NMR, SAXS, MS, CD, Fluorescence, Absorbance...):

- Peptide and carbohydrate mimetic design of molecules targeting the Siglec domains.

- Protein-ligand binding characterizations.