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Dixon Group Publications


  • Brooks, R.L. and Dixon, A.M., Revealing the Mechanism of Protein-Lipid Interactions for a Putative Membrane Curvature Sensor in Plant Endoplasmic Reticulum, BBA Biomembranes, 2020, 1862,


  • Hasan, M., Patel, D., Ellis, N., Brown, S.P., Lewandowski, J.R., and Dixon, A.M., Modulation of Transmembrane Domain Interactions in Neu Receptor Tyrosine Kinase by Membrane Fluidity and Cholesterol, J. Membrane Biol., 2019, 252, 357-369 (Invited Submission to Special Issue).
  • Roesner, S., Saunders, G.J., Wilkening, I., Jayawant, E., Geden, J.V., Kerby, P., Dixon, A.M., Notman, R., and Shipman, M., Macrocyclization of Small Peptides Enabled by Oxetane Incorporation, Chemical Science, 2019, 10, 2465-2472, DOI: 10.1039/C8SC05474F.
  • Dixon, A.M. and Roy, S., Role of Membrane Environment and Membrane-Spanning Protein Regions in Assembly and Function of the Class II Major Histocompatibility Complex, Human Immunology, 2019, 80, 5-14 (Invited Submission to Special Issue).


  • Chow, M., Sklepari, M., Frigerio, L. and Dixon, A.M., Bacterial expression, purification and biophysical characterization of the smallest plant reticulon isoform, RTNLB13, Prot. Expr. Purif., 2018, 152, 31-39.
  • Jeyaharan, D., Brackstone, C., Schouten, J., Davis, P., and Dixon, A.M., Characterisation of the Carboxypeptidase G2 Catalytic Site and Design of New Inhibitors for Cancer Therapy, ChemBioChem, 2018, 19, 1959-1968.


  • Jeyaharan, D., Aston, P., Garcia-Perez, A., Schouten, J., Davis, P., and Dixon, A.M., Soluble expression, purification and functional characterisation of carboxypeptidase G2 and its individual domains, Prot. Expr. Purif., 2016, 127, 44–52.
  • Breeze, E., Dzimitrowicz, N., Kriechbaumer, V., Brooks, R., Botchway, S.W., Brady, J.P., Hawes, C., Dixon, A.M., Schnell, J.R., Fricker, M.D., Frigerio, L., A C-terminal amphipathic helix is necessary for the in vivo tubule-shaping function of a plant reticulon, Proc. Natl. Acad. Sci., 2016, 113, 10902-10907.


  • Nash, A., Notman, R., and Dixon, A.M., De novo Design of Transmembrane Helix-Helix Interactions and Measurement of Stability in a Biological Membrane. Biochimica et Biophysica Acta – Biomembranes, 2015, 1848, 1248-1257.
  • David Barneda, Joan Planas-Iglesias, Maria L Gaspar, Dariush Mohammadyani, Sunil Prasannan, Dirk Dormann, Gil-Soo Han, Stephen A Jesch, George M Carman, Valerian Kagan, Malcolm G Parker, Nicholas T Ktistakis, Judith Klein-Seetharaman, Ann M Dixon, Susan Henry, Mark Christian, The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding, eLife 2015;10.7554/eLife.07485.


  • Dixon, A.M., Drake, L., Hughes, K.T., Sargent, E., Hunt, D., Harton, J.A., Drake, J.R. Differential Transmembrane Domain GxxxG Motif Pairing Impacts MHC Class II Structure, J. Biol. Chem., 2014, 289, p. 11695-703
  • Probert, F., Mitchell, D.A., Dixon, A.M., NMR evidence for oligosaccharide release from the DC-SIGNR (CLEC4M) carbohydrate recognition domain at low pH, FEBS J., 2014, 281, p. 3739-3750
  • Lock, A., Forfar, R., Weston, C., Bowsher, L., Upton, G.J.G., Reynolds, C.A., Ladds, G., Dixon, A.M., One Motif to Bind Them: A Small-XXX-Small Motif Affects Transmembrane Domain 1 Oligomerization, Function, Localization, and Cross-talk Between Two Yeast GPCRs, Biochimica et Biophysica Acta – Biomembranes, 2014, 1838, p. 3036-3051.


  • Probert, F., Whittaker, S.B.M., Crispin, M., Mitchell, D.A., Dixon, A.M. Solution NMR Analyses of the C-type Carbohydrate Recognition Domain of DC-SIGNR Protein Reveal Different Binding Modes for HIV-derived Oligosaccharides and Smaller Glycan Fragments, J. Biol. Chem., 2013, 288, p. 22745-22757.


  • Beevers, A.J., Nash, A., Salazar-Cancino, M., Scott, D.J., Notman, R., and Dixon, A.M., Effects of the Oncogenic V664E Mutation on Membrane Insertion, Structure, and Sequence-dependent Interactions of the Neu Transmembrane Domain in Micelles and Model Memebranes: An Integrated Biophysical and Simulation Study, Biochemistry, 2012, 51, p. 2558-2568.


  • Jenei, Z.A., Warren, G.Z.L., Hasan, M., Zammit, V.A. and Dixon, A.M. Packing of Transmembrane Domain 2 of Carnitine Palmitoyltransferase-1A affects Oligomerization and Malonyl-CoA Sensitivity of the Mitochondrial Outer Membrane Protein, FASEB J, 2011, 25, p. 4522-4530.
  • King, G., Oates, J., Patel, D., van den Berg, H., and Dixon, A.M., Towards a Structural Understanding of the Smallest Known Oncoprotein: Investigation of the Bovine Papillomavirus E5 Protein using Solution-state NMR, BBA - Biomembranes, 2011, 1808, p. 1493-1501.


  • King, G. and Dixon, A.M. Evidence for Role of Transmembrane Helix-Helix Interactions in the Assembly of the Class II Major Histocompatibility Complex, Molecular BioSystems, 2010, 6, p. 1650-1661
  • Oates, J., King. G., and Dixon, A.M. Strong oligomerization behavior of PDGFβ receptor transmembrane domain and its regulation by the juxtamembrane regions, Biochim Biophys Acta, 2010, 1798(3), p. 605-615
  • Beevers, A.J. and Dixon, A.M., Helical Membrane Peptides to Modulate Cell Function, Chemical Society Reviews, 2010, 39, p. 2146-2157
  • Beevers, A.J., Damianoglou, A., Oates, J., Rodger, A., Dixon, A.M., Sequence Dependent Oligomerization of the Neu Transmembrane Domain Suggests Inhibition of 'Conformational Switching' by Oncogenic Mutant, Biochemistry, 2010, 49, p. 2811-2820.


  • Tablert-Slagle, K., Marlatt, S., Barrera, F.N., Khurana, E., Oates, J., Gerstein, M., Engelman, D.M., Dixon, A.M., DiMaio, D., Artificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor beta receptor, Journal of Virology, 2009, 83, p. 9773-9785.
  • Jenei, Z.A., Borthwick, K., Zammit, V.A. and Dixon, A.M., Self-association of Transmembrane Domain 2, but not TM1, in Carnitine Palmitoyltransferase 1A: Role of GxxxG(A) Motifs, Journal of Biological Chemistry, 2009, 284, p. 6988-6997.
  • Warren, G., Oates, J., Robinson, C., and Dixon, A.M., Contributions of the Transmembrane Domain, Amphipathic Helix and a Key Acidic Motif to Assembly and Function of the TatA Complex, Journal of Molecular Biology, 2009, 388, p. 122-132.


  • King, G. and Dixon, A. M., "Techniques to study membrane protein structure", Wiley Encyclopedia of Chemical Biology, WileyBlackwell Publishing, 2008.
  • Oates, J., Hicks, M., Dafforn, T., DiMaio, D., Dixon, A.M., In Vitro Dimerization of the Bovine Papillomavirus E5 Protein, Biochemistry, 2008, 47, p. 8985-8992.


  • Dixon, A. M., Stanley B.J., Matthews, E.E., Dawson, J.P., Engelman, D.M., Invariant chain transmembrane domain trimerization: A step in MHC class II assembly, Biochemistry, 2006, 45, p. 5228-5234.


  • Freeman-Cook LL, Edwards AP, Dixon AM, Yates KE, Ely L, Engelman DM, Dimaio D. Specific locations of hydrophilic amino acids in constructed transmembrane ligands of the platelet-derived growth factor beta receptor, Journal of Molecular Biology, 2005, 345, p.907-921.


  • Freeman-Cook, L.L., Dixon, A.M., Frank, J.B., Xia, Y., Ely, L., Gerstein, M., Engelman, D.M., DiMaio, D., Selection and Characterization of Small Random Transmembrane Proteins that Bind and Activate the Platelet-derived Growth Factor Beta Receptor. Journal of Molecular Biology, 2004, 338, p.907-920.


  • Engelman, D.M., Chen, Y., Chin, C-N., Curran, A.R., Dixon, A.M., Dupuy, A., Lee, A., Lehnert, U., Matthews, E.E., Reshetnyak, Senes, A., Popot, J-L., Membrane Protein Folding: Beyond the Two Stage Model, FEBS Letters, 2003, 555, p. 122-125.
  • Dixon, A.M., Venable, R.M., Widmalm, G., Bull, T.E. and Pastor, R.W. Application of NMR, Molecular Simulation, and Hydrodynamics to Conformational Analysis of Trisaccharides, Biopolymers, 2003, 69, p. 448-460.


  • Dixon, A.M., Venable, R.M., Pastor, R.W., and Bull, T.E. Micelle-Bound Conformation of a Hairpin-Forming Peptide: Combined NMR and Molecular Dynamics Study, Biopolymers, 2002, 65(4), p. 284-298.
  • Wilk, A., Grajkowski, A., Bull, T.E., Dixon, A.M., Freedberg, D. and Beaucage, S.L. Direct Assignment of the Absolute Configuration of a Distinct Class of Deoxyribonucleoside Cyclic N-Acylphosphoramidites at Phosphorus by M-GOESY Nuclear Magnetic Resonance Spectroscopy, Journal of the American Chemical Society, 2002, 124, p. 1180-1181.


  • Dixon, A.M., Widmalm, G., and Bull, T.E. Modified GOESY in the Analysis of Disaccharide Conformation, Journal of Magnetic Resonance, 2000, 147, p. 266-272.