Sam Weekes
PhD
Nitrosamines are a major threat due to their carcinogenic nature. Since 2018, nitrosated drug substance related impurities (NDSRIs) have become a global challenge, resulting in many batch recalls. Low acceptable intake levels have made nitrosamines a challenge to identify and growing complexity of NDSRIs with multiple nitrosation sites, increase the immediate need for reliable methods to identify the toxic byproducts. The nitroso group is very labile and dissociates under minimal conditions which as a result makes CID limited in its ability to locate the position of the nitroso group.
Figure. 2 NDSRI CID MS/MS spectra showing how the nitroso group is not retained on any fragments
One aim of my project is to apply tandem mass spectrometry techniques to understand and identify nitrosated drug substance related impurities. Developing workflows based on the accumulative results to streamline nitrosamine analysis for pharmaceutical relevance.
Academic Background
Masters in Chemistry (MChem) - University of Warwick (2020 - 2024)
PGcert in Analytical Science - University of Warwick (2024-2025)
PhD in Analytical Science - University of Warwick (2024-Current)
Conferences
BMSS 2026 - Oral
IMSC 2026 - Poster
EFTMS 2026 - Flash Oral + Poster
BMSS 2024 - Flash Oral + Poster Presentation
Polymer Club Conference 2024 - Poster Presentation
University of Warwick Symposium 2026
- Poster
Polymer Club Conference 2025 -
Poster
BMSS 2025
- Flash Oral + Poster Presentation
BMSS 2024
- Flash Oral + Poster Presentation
Contact Details
Email - Sam.weekes@warwick.ac.uk
Ion Cyclotron Resonance Laboratory
University of Warwick
Coventry
CV4 7AL
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